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  1. Content type: Research

    Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases...

    Authors: Martin Letzkus, Evert Luesink, Sandrine Starck-Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson and Frank Staedtler

    Citation: Clinical and Translational Medicine 2014 3:36

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  2. Content type: Editorial

    Unfortunately, the research effort directed into chronic obstructive pulmonary disease (COPD) has been disproportionately weak compared to its social importance, and indeed it is the least researched of all co...

    Authors: Sukhwinder Singh Sohal, Malik Quasir Mahmood and Eugene Haydn Walters

    Citation: Clinical and Translational Medicine 2014 3:33

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  3. Content type: Research

    Urine markers have been studied extensively but there is a lack of blood prognostic markers in bladder cancer. MMP-7 is produced by stromal cells and by tumor cells and is overexpressed in a variety of epithel...

    Authors: Mounira El Demery, Gaiané Demirdjian-Sarkissian, Simon Thezenas, William Jacot, Yassine Laghzali, Bruno Darbouret, Stéphane Culine, Xavier Rebillard and Pierre-Jean Lamy

    Citation: Clinical and Translational Medicine 2014 3:31

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  4. Content type: Review

    Acute Respiratory Distress Syndrome (ARDS) is a devastating cause of hypoxic respiratory failure, which continues to have high mortality. It is expected that a comprehensive systems- level approach will identi...

    Authors: Maneesh Bhargava, LeeAnn Higgins, Christine H Wendt and David H Ingbar

    Citation: Clinical and Translational Medicine 2014 3:34

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  5. Content type: Review

    In the past decade, the traditional view of cancers as a homogeneous collection of malignant cells is being replaced by a model of ever increasing complexity suggesting that cancers are complex tissues compose...

    Authors: Yongyou Zhu, Ming Luo, Michael Brooks, Shawn G Clouthier and Max S Wicha

    Citation: Clinical and Translational Medicine 2014 3:32

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  6. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by mucus hypersecretion that contributes to disease related morbidity and is associated with increased mortality. The Lung Flute® is a new respirat...

    Authors: Sanjay Sethi, Jingjing Yin and Pamela K Anderson

    Citation: Clinical and Translational Medicine 2014 3:29

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  7. Content type: Research

    Snail, a transcriptional factor and repressor of E-cadherin is well known for its role in cellular invasion. It can regulate epithelial to mesenchymal transition (EMT) during embryonic development and in epith...

    Authors: Samar Abdulkhalek, Olivia D Geen, Lacey Brodhagen, Fiona Haxho, Farah Alghamdi, Stephanie Allison, Duncan J Simmons, Leah K O'Shea, Ronald J Neufeld and Myron R Szewczuk

    Citation: Clinical and Translational Medicine 2014 3:28

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  8. Content type: Review

    Control of cell number and organ size is critical for appropriate development and tissue homeostasis. Studies in both Drosophila and mammals have established the Hippo signaling pathway as an important modulator ...

    Authors: Dominic P Del Re

    Citation: Clinical and Translational Medicine 2014 3:27

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    The Erratum to this article has been published in Clinical and Translational Medicine 2015 4:12

  9. Content type: Review

    The management of Ventilator Associated Pneumonia (VAP) presents many difficulties because of the heterogeneity of the disease; the way the immunocompromised host and the aggressive ICU environment interact is...

    Authors: Ornella Piazza and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2014 3:26

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  10. Content type: Review

    The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used ...

    Authors: Alexander Aleynik, Kevin M Gernavage, Yasmine SH Mourad, Lauren S Sherman, Katherine Liu, Yuriy A Gubenko and Pranela Rameshwar

    Citation: Clinical and Translational Medicine 2014 3:24

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  11. Content type: Review

    Understanding the molecular nature of human cancer is essential to the development of effective and personalized therapies. Several different molecular signal transduction pathways drive tumorigenesis when der...

    Authors: Daniel A Barron and Jacob D Kagey

    Citation: Clinical and Translational Medicine 2014 3:25

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  12. Content type: Review

    The Hippo tumour suppressor pathway co-ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a conserved core Hippo signalling module receives signal ...

    Authors: Marta Gomez, Valenti Gomez and Alexander Hergovich

    Citation: Clinical and Translational Medicine 2014 3:22

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  13. Content type: Research

    Therapies based on mesenchymal stem cells (MSC) have been shown to have potential benefit in several clinical studies. We have shown that, using a medium-based approach, MSC can be induced to secrete elevated ...

    Authors: Yael Gothelf, Natalie Abramov, Adrian Harel and Daniel Offen

    Citation: Clinical and Translational Medicine 2014 3:21

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  14. Content type: Perspective

    The transfer of new scientific discoveries into healthcare interventions requires that basic and clinical researchers work together with health care providers to generate team science. These innovative models ...

    Authors: Estela S Estape, Mary Helen Mays, Rosanne Harrigan and Robert Mayberry

    Citation: Clinical and Translational Medicine 2014 3:20

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  15. Content type: Commentary

    Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic. The present co...

    Authors: Peixin Huang and Elena López Villar

    Citation: Clinical and Translational Medicine 2014 3:18

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  16. Content type: Review

    The concept of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research commun...

    Authors: Konrad Steinestel, Stefan Eder, Andres Jan Schrader and Julie Steinestel

    Citation: Clinical and Translational Medicine 2014 3:17

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  17. Content type: Review

    In 2010, Multilineage Differentiating Stress Enduring (Muse) cells were introduced to the scientific community, offering potential resolution to the issue of teratoma formation that plagues both embryonic stem...

    Authors: Ariel A Simerman, Daniel A Dumesic and Gregorio D Chazenbalk

    Citation: Clinical and Translational Medicine 2014 3:12

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  18. Content type: Review

    Using human pluripotent stem cells as a source to generate differentiated progenies for regenerative medicine applications has attracted substantial interest during recent years. Having the capability to produ...

    Authors: Peter Sartipy and Petter Björquist

    Citation: Clinical and Translational Medicine 2014 3:9

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  19. Content type: Research

    Ventilator-associated pneumonia (VAP) is a leading hospital acquired infection in intensive care units despite improved patient care practices and advancements in endotracheal tube (ETT) designs. The ETT provi...

    Authors: Rhea M May, Matthew G Hoffman, Melinda J Sogo, Albert E Parker, George A O’Toole, Anthony B Brennan and Shravanthi T Reddy

    Citation: Clinical and Translational Medicine 2014 3:8

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  20. Content type: Review

    Biomarker research is continuously expanding in the field of clinical proteomics. A combination of different proteomic–based methodologies can be applied depending on the specific clinical context of use. More...

    Authors: Maria Frantzi, Akshay Bhat and Agnieszka Latosinska

    Citation: Clinical and Translational Medicine 2014 3:7

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  21. Content type: Review

    Recent scientific breakthroughs in stem cell biology suggest that a sustainable treatment approach to cure diabetes mellitus (DM) can be achieved in the near future. However, the transplantation complexities a...

    Authors: Ganesh N Pandian, Junichi Taniguchi and Hiroshi Sugiyama

    Citation: Clinical and Translational Medicine 2014 3:6

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  22. Content type: Commentary

    Tympanic membrane perforations (TMP) are relatively common but are typically not treated in their acute stage, as most will heal spontaneously in 7–10 days. Those cases which fail to heal within 3 months are c...

    Authors: Allen Y Wang, Yi Shen, Jeffrey T Wang, Robert H Eikelboom and Rodney J Dilley

    Citation: Clinical and Translational Medicine 2014 3:5

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  23. Content type: Commentary

    The use of paraffin slides and tissue microarrays (TMA) is indispensable for translational research. However, storage of paraffin slides over time has a substantial detrimental effect on the quality and reliab...

    Authors: Mary Economou, Liliane Schöni, Caroline Hammer, José A Galván, Dominique-Elisabeth Mueller and Inti Zlobec

    Citation: Clinical and Translational Medicine 2014 3:4

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  24. Content type: Review

    Because of the economic growth and changes in lifestyle, metabolic diseases have become a major public health problem, which impose heavy economic burdens on individuals, families and health systems. However, ...

    Authors: Lin Shi, Elena López Villar and Chengshui Chen

    Citation: Clinical and Translational Medicine 2014 3:2

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  25. Content type: Research

    FKBP51 (FKBP5 Official Symbol) is a large molecular weight component of the family of FK506 binding proteins (FKBP). In recent years, research studies from our laboratory highlighted functions for FKBP51 in th...

    Authors: Simona Romano, Anna D’Angelillo, Paolo D’Arrigo, Stefania Staibano, Adelaide Greco, Arturo Brunetti, Massimiliano Scalvenzi, Rita Bisogni, Iris Scala and Maria Fiammetta Romano

    Citation: Clinical and Translational Medicine 2014 3:1

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  26. Content type: Perspective

    Personalized Medicine has the potential to improve health outcomes and reduce the cost of care; however its adoption has been slow in Canada. Bridgepoint Health is a complex continuous care provider striving t...

    Authors: Ruslan Dorfman, Zayna Khayat, Tammy Sieminowski, Brian Golden and Renee Lyons

    Citation: Clinical and Translational Medicine 2013 2:16

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  27. Content type: Research

    Molecular analysis of sputum provides a promising approach for lung cancer diagnosis, yet is limited by the difficulty in collecting the specimens from individuals who can’t spontaneously expectorate sputum. L...

    Authors: Nigar Anjuman, Ning Li, Maria Guarnera, Sanford A Stass and Feng Jiang

    Citation: Clinical and Translational Medicine 2013 2:15

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  28. Content type: Perspective

    Translating the knowledge from biomedical science into clinical applications that help patients has been compared to crossing a valley of death because of the many issues that separate the bench from the bedsi...

    Authors: Eric M Meslin, Alessandro Blasimme and Anne Cambon-Thomsen

    Citation: Clinical and Translational Medicine 2013 2:14

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  29. Content type: Research

    The gaseous headspace above naïve Escherichia Coli (E. coli) cultures and whole human blood inoculated with E. coli were collected and analyzed for the presence of trace gases that may have the potential to be us...

    Authors: Brandon J Umber, Hye-Won Shin, Simone Meinardi, Szu-Yun Leu, Frank Zaldivar, Dan M Cooper and Donald R Blake

    Citation: Clinical and Translational Medicine 2013 2:13

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  30. Content type: Research

    Previous studies of epidermal kinetics in psoriasis have relied on invasive biopsy procedures or the use of radioactive labels. We previously developed a non-invasive method for measuring keratin synthesis in ...

    Authors: Claire L Emson, Sarah Fitzmaurice, Glen Lindwall, Kelvin W Li, Marc K Hellerstein, Howard I Maibach, Wilson Liao and Scott M Turner

    Citation: Clinical and Translational Medicine 2013 2:12

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  31. Content type: Perspective

    Our current health research enterprise is painstakingly slow and cumbersome, and its results seldom translate into practice. The slow pace of health research contributes to findings that are less relevant and ...

    Authors: William T Riley, Russell E Glasgow, Lynn Etheredge and Amy P Abernethy

    Citation: Clinical and Translational Medicine 2013 2:10

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  32. Content type: Review

    Two direct-acting antivirals (DAAs) against hepatitis C virus (HCV): telaprevir and boceprevir, are now available in combination with peginterferon plus ribavirin for the treatment of chronic hepatitis C infec...

    Authors: Tatsuo Kanda, Osamu Yokosuka and Masao Omata

    Citation: Clinical and Translational Medicine 2013 2:9

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  33. Content type: Review

    Maspin (mammary serine protease inhibitor), is a member of the serine protease inhibitor/non-inhibitor superfamily. Its expression is down-regulated in breast, prostate, gastric and melanoma cancers but over-e...

    Authors: Rossana Berardi, Francesca Morgese, Azzurra Onofri, Paola Mazzanti, Mirco Pistelli, Zelmira Ballatore, Agnese Savini, Mariagrazia De Lisa, Miriam Caramanti, Silvia Rinaldi, Silvia Pagliaretta, Matteo Santoni, Chiara Pierantoni and Stefano Cascinu

    Citation: Clinical and Translational Medicine 2013 2:8

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  34. Content type: Research

    The objectives and goals of the Southern Swedish Malignant Melanoma (SSMM)are to develop, build and utilize cutting edge biobanks and OMICS platformsto better understand disease pathology and drug mechanisms. ...

    Authors: Charlotte Welinder, Göran Jönsson, Christian Ingvar, Lotta Lundgren, Håkan Olsson, Thomas Breslin, Ákos Végvári, Thomas Laurell, Melinda Rezeli, Bo Jansson, Bo Baldetorp and György Marko-Varga

    Citation: Clinical and Translational Medicine 2013 2:7

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  35. Content type: Review

    The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted ti...

    Authors: Batool Mutar Mahdi

    Citation: Clinical and Translational Medicine 2013 2:6

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  36. Content type: Perspective

    We propose A step-by-step roadmap to integrate genetics in the Electronic Patient Record in Family Medicine and clinical research. This could make urgent operationalization of readily available genetic knowled...

    Authors: Elisa JF Houwink, Annet W Sollie, Mattijs E Numans and Martina C Cornel

    Citation: Clinical and Translational Medicine 2013 2:5

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  37. Content type: Review

    Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recur...

    Authors: Lissa Nurrul Abdullah and Edward Kai-Hua Chow

    Citation: Clinical and Translational Medicine 2013 2:3

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