Skip to main content

Articles

Page 5 of 7

  1. In the new pathologic classification of lung adenocarcinoma proposed by IASLC/ATS/ERS in 2011, lepidic type adenocarcinomas are constituted by three subtypes; adenocarcinoma in situ (AIS), minimally invasive a...

    Authors: Yasufumi Kato, Haruhiko Nakamura, Hiromasa Tojo, Masaharu Nomura, Toshitaka Nagao, Takeshi Kawamura, Tatsuhiko Kodama, Tatsuo Ohira, Norihiko Ikeda, Thomas Fehniger, György Marko-Varga, Toshihide Nishimura and Harubumi Kato
    Citation: Clinical and Translational Medicine 2015 4:24
  2. Despite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic fac...

    Authors: Wei Chen and Lorraine B Ware
    Citation: Clinical and Translational Medicine 2015 4:23
  3. Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and infl...

    Authors: Li Ma, Ciara M. Shaver, Brandon S. Grove, Daphne B. Mitchell, Nancy E. Wickersham, Robert H. Carnahan, Tracy L. Cooper, Brittany E. Brake, Lorraine B. Ware and Julie A. Bastarache
    Citation: Clinical and Translational Medicine 2015 4:22
  4. As the high throughput sequencing efforts generate more biological information, scientists from different disciplines are interpreting the polymorphisms that make us unique. In addition, there is an increasing...

    Authors: Timo Tiirikka and Jukka S Moilanen
    Citation: Clinical and Translational Medicine 2015 4:20
  5. In spite of the implementations of several strategies, tuberculosis (TB) is overwhelmingly a serious global public health problem causing millions of infections and deaths every year. This is mainly due to the...

    Authors: Tilahun Melak and Sunita Gakkhar
    Citation: Clinical and Translational Medicine 2015 4:19
  6. The activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation and survival, is orchestrated by protein kinases via phosphorylation. A critical i...

    Authors: Elena López Villar, Luis Madero, Juan A López-Pascual and William C Cho
    Citation: Clinical and Translational Medicine 2015 4:18
  7. To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in a Cameroonian population.

    Authors: Dieudonne Nanfa, Eugene Sobngwi, Barbara Atogho-Tiedeu, Jean Jacques N Noubiap, Olivier Sontsa Donfack, Edith Pascale Mato Mofo, Magellan Guewo-Fokeng, Aurelie Nguimmo Metsadjio, Elvis Ndonwi Ngwa, Priscille Pokam Fosso, Eric Djahmeni, Rosine Djokam-Dadjeu, Marie-Solange Evehe, Folefac Aminkeng, Wilfred F Mbacham and Jean Claude Mbanya
    Citation: Clinical and Translational Medicine 2015 4:17
  8. Fine needle aspiration (FNA) biopsy plays a critical role in the diagnosis and staging of lung primary and metastatic lung carcinoma. Accurate subclassification of adenocarcinoma (ADC) and/or squamous cell car...

    Authors: Grzegorz T Gurda, Lei Zhang, Yuting Wang, Li Chen, Susan Geddes, William C Cho, Frederic Askin, Edward Gabrielson and Qing Kay Li
    Citation: Clinical and Translational Medicine 2015 4:16
  9. Graduate medical education has traditionally focused on training future physicians to be outstanding clinicians with basic and clinical science research skills. This focus has resulted in substantial knowledge...

    Authors: Patrick D Loftus, Craig T Elder, Troy D’Ambrosio and John T Langell
    Citation: Clinical and Translational Medicine 2015 4:15
  10. Epithelial mesenchymal transition (EMT) is a physiological process necessary to normal embryologic development. However in genesis of pathological situations, this transition can be perverted and signaling pat...

    Authors: Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri and Michel Rigaud
    Citation: Clinical and Translational Medicine 2015 4:14
  11. Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited...

    Authors: William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston and Johann E Gudjonsson
    Citation: Clinical and Translational Medicine 2015 4:13
  12. Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implic...

    Authors: Ranjit Ganguly, Ahmed Mohyeldin, Jordyn Thiel, Harley I Kornblum, Monique Beullens and Ichiro Nakano
    Citation: Clinical and Translational Medicine 2015 4:11
  13. Low grade gliomas are the most common brain tumor in children. Tandem duplication involving the KIAA1549 and the BRAF kinase genes results in a gene fusion that has been recently characterized in a subset of low ...

    Authors: Hala Taha, Maha Yehia, Madeha Mahmoud, Mohamed El-Beltagy, Myret Ghabriel and Shahenda El-Naggar
    Citation: Clinical and Translational Medicine 2015 4:10
  14. Catheter-related bloodstream infections (CRBSIs) and catheter-related thrombosis (CRT) are common complications of central venous catheters (CVC), which are used to monitor patient health and deliver medicatio...

    Authors: Rhea M May, Chelsea M Magin, Ethan E Mann, Michael C Drinker, John C Fraser, Christopher A Siedlecki, Anthony B Brennan and Shravanthi T Reddy
    Citation: Clinical and Translational Medicine 2015 4:9
  15. Tissue macrophages play important roles in maintaining homeostasis in most organs of the body including the brain where microglia represent the resident phagocytic cells of this compartment. The possibility of...

    Authors: Amanda Brown
    Citation: Clinical and Translational Medicine 2015 4:7
  16. EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these pr...

    Authors: Sarah Heerboth, Genevieve Housman, Meghan Leary, Mckenna Longacre, Shannon Byler, Karolina Lapinska, Amber Willbanks and Sibaji Sarkar
    Citation: Clinical and Translational Medicine 2015 4:6
  17. Monocytes are primitive hematopoietic cells that primarily arise from the bone marrow, circulate in the peripheral blood and give rise to differentiated macrophages. Over the past two decades, considerable att...

    Authors: Brian K Stansfield and David A Ingram
    Citation: Clinical and Translational Medicine 2015 4:5
  18. Fatigue is common in cancer patients receiving adjuvant chemotherapy. To further understand the mechanism of fatigue and search for potential biomarkers, we conducted this prospective study. Methods

    Authors: Felipe M Cruz, Bruna A Munhoz, Beatriz CA Alves, Flavia S Gehrke, Fernando LA Fonseca, Renata K Kuniyoshi, Daniel Cubero, Luke J Peppone and Auro del Giglio
    Citation: Clinical and Translational Medicine 2015 4:4
  19. Childhood immunisation is one of the greatest public health successes of the last century. Vaccines contain an active component (the antigen) which induces the immune response. They may also contain additional...

    Authors: Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Giuseppe Crisafulli, Liotti Lucia, Diego Peroni, Francesca Saretta, Mario Vernich, Carlotta Povesi Dascola and Carlo Caffarelli
    Citation: Clinical and Translational Medicine 2015 4:3
  20. The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality. The molecu...

    Authors: Peter J Wermuth and Sergio A Jimenez
    Citation: Clinical and Translational Medicine 2015 4:2
  21. Intestinal fibrosis and subsequent stricture formation represent frequent complications of Crohn’s disease (CD). In many organs, fibrosis develops as a result of epithelial to mesenchymal transition (EMT). Rec...

    Authors: Michael Scharl, Nicole Huber, Silvia Lang, Alois Fürst, Ekkehard Jehle and Gerhard Rogler
    Citation: Clinical and Translational Medicine 2015 4:1
  22. Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT ...

    Authors: Christian A Graves, Fadi F Abboodi, Swati Tomar, James Wells and Lucia Pirisi
    Citation: Clinical and Translational Medicine 2014 3:39
  23. Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macro...

    Authors: Hannah C Bygd, Kiva D Forsmark and Kaitlin M Bratlie
    Citation: Clinical and Translational Medicine 2014 3:62
  24. The Tokyo Medical University Hospital in Japan and the Lund University hospital in Sweden have recently initiated a research program with the objective to impact on patient treatment by clinical disease stage ...

    Authors: Toshihide Nishimura, Takeshi Kawamura, Yutaka Sugihara, Yasuhiko Bando, Shigeru Sakamoto, Masaharu Nomura, Norihiko Ikeda, Tatsuo Ohira, Junichiro Fujimoto, Hiromasa Tojo, Takao Hamakubo, Tatsuhiko Kodama, Roland Andersson, Thomas E Fehniger, Harubumi Kato and György Marko-Varga
    Citation: Clinical and Translational Medicine 2014 3:61
  25. We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-...

    Authors: Yuchen Sun, Tomomi Furihata, Seiya Ishii, Miki Nagai, Manami Harada, Osamu Shimozato, Takehiko Kamijo, Shinichiro Motohashi, Ichiro Yoshino, Atsuko Kamiichi, Kaoru Kobayashi and Kan Chiba
    Citation: Clinical and Translational Medicine 2014 3:37
  26. Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases...

    Authors: Martin Letzkus, Evert Luesink, Sandrine Starck-Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson and Frank Staedtler
    Citation: Clinical and Translational Medicine 2014 3:36
  27. Unfortunately, the research effort directed into chronic obstructive pulmonary disease (COPD) has been disproportionately weak compared to its social importance, and indeed it is the least researched of all co...

    Authors: Sukhwinder Singh Sohal, Malik Quasir Mahmood and Eugene Haydn Walters
    Citation: Clinical and Translational Medicine 2014 3:33
  28. Urine markers have been studied extensively but there is a lack of blood prognostic markers in bladder cancer. MMP-7 is produced by stromal cells and by tumor cells and is overexpressed in a variety of epithel...

    Authors: Mounira El Demery, Gaiané Demirdjian-Sarkissian, Simon Thezenas, William Jacot, Yassine Laghzali, Bruno Darbouret, Stéphane Culine, Xavier Rebillard and Pierre-Jean Lamy
    Citation: Clinical and Translational Medicine 2014 3:31
  29. Acute Respiratory Distress Syndrome (ARDS) is a devastating cause of hypoxic respiratory failure, which continues to have high mortality. It is expected that a comprehensive systems- level approach will identi...

    Authors: Maneesh Bhargava, LeeAnn Higgins, Christine H Wendt and David H Ingbar
    Citation: Clinical and Translational Medicine 2014 3:34
  30. In the past decade, the traditional view of cancers as a homogeneous collection of malignant cells is being replaced by a model of ever increasing complexity suggesting that cancers are complex tissues compose...

    Authors: Yongyou Zhu, Ming Luo, Michael Brooks, Shawn G Clouthier and Max S Wicha
    Citation: Clinical and Translational Medicine 2014 3:32
  31. Chronic obstructive pulmonary disease (COPD) is characterized by mucus hypersecretion that contributes to disease related morbidity and is associated with increased mortality. The Lung Flute® is a new respirat...

    Authors: Sanjay Sethi, Jingjing Yin and Pamela K Anderson
    Citation: Clinical and Translational Medicine 2014 3:29
  32. Snail, a transcriptional factor and repressor of E-cadherin is well known for its role in cellular invasion. It can regulate epithelial to mesenchymal transition (EMT) during embryonic development and in epith...

    Authors: Samar Abdulkhalek, Olivia D Geen, Lacey Brodhagen, Fiona Haxho, Farah Alghamdi, Stephanie Allison, Duncan J Simmons, Leah K O'Shea, Ronald J Neufeld and Myron R Szewczuk
    Citation: Clinical and Translational Medicine 2014 3:28
  33. Control of cell number and organ size is critical for appropriate development and tissue homeostasis. Studies in both Drosophila and mammals have established the Hippo signaling pathway as an important modulator ...

    Authors: Dominic P Del Re
    Citation: Clinical and Translational Medicine 2014 3:27

    The Erratum to this article has been published in Clinical and Translational Medicine 2015 4:12

  34. The management of Ventilator Associated Pneumonia (VAP) presents many difficulties because of the heterogeneity of the disease; the way the immunocompromised host and the aggressive ICU environment interact is...

    Authors: Ornella Piazza and Xiangdong Wang
    Citation: Clinical and Translational Medicine 2014 3:26
  35. The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used ...

    Authors: Alexander Aleynik, Kevin M Gernavage, Yasmine SH Mourad, Lauren S Sherman, Katherine Liu, Yuriy A Gubenko and Pranela Rameshwar
    Citation: Clinical and Translational Medicine 2014 3:24
  36. Understanding the molecular nature of human cancer is essential to the development of effective and personalized therapies. Several different molecular signal transduction pathways drive tumorigenesis when der...

    Authors: Daniel A Barron and Jacob D Kagey
    Citation: Clinical and Translational Medicine 2014 3:25
  37. The Hippo tumour suppressor pathway co-ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a conserved core Hippo signalling module receives signal ...

    Authors: Marta Gomez, Valenti Gomez and Alexander Hergovich
    Citation: Clinical and Translational Medicine 2014 3:22
  38. Therapies based on mesenchymal stem cells (MSC) have been shown to have potential benefit in several clinical studies. We have shown that, using a medium-based approach, MSC can be induced to secrete elevated ...

    Authors: Yael Gothelf, Natalie Abramov, Adrian Harel and Daniel Offen
    Citation: Clinical and Translational Medicine 2014 3:21
  39. The transfer of new scientific discoveries into healthcare interventions requires that basic and clinical researchers work together with health care providers to generate team science. These innovative models ...

    Authors: Estela S Estape, Mary Helen Mays, Rosanne Harrigan and Robert Mayberry
    Citation: Clinical and Translational Medicine 2014 3:20
  40. Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic. The present co...

    Authors: Peixin Huang and Elena López Villar
    Citation: Clinical and Translational Medicine 2014 3:18
  41. The concept of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research commun...

    Authors: Konrad Steinestel, Stefan Eder, Andres Jan Schrader and Julie Steinestel
    Citation: Clinical and Translational Medicine 2014 3:17