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  1. Content type: Perspective

    The transfer of new scientific discoveries into healthcare interventions requires that basic and clinical researchers work together with health care providers to generate team science. These innovative models ...

    Authors: Estela S Estape, Mary Helen Mays, Rosanne Harrigan and Robert Mayberry

    Citation: Clinical and Translational Medicine 2014 3:20

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  2. Content type: Commentary

    Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic. The present co...

    Authors: Peixin Huang and Elena López Villar

    Citation: Clinical and Translational Medicine 2014 3:18

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  3. Content type: Review

    The concept of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research commun...

    Authors: Konrad Steinestel, Stefan Eder, Andres Jan Schrader and Julie Steinestel

    Citation: Clinical and Translational Medicine 2014 3:17

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  4. Content type: Review

    In 2010, Multilineage Differentiating Stress Enduring (Muse) cells were introduced to the scientific community, offering potential resolution to the issue of teratoma formation that plagues both embryonic stem...

    Authors: Ariel A Simerman, Daniel A Dumesic and Gregorio D Chazenbalk

    Citation: Clinical and Translational Medicine 2014 3:12

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  5. Content type: Review

    Using human pluripotent stem cells as a source to generate differentiated progenies for regenerative medicine applications has attracted substantial interest during recent years. Having the capability to produ...

    Authors: Peter Sartipy and Petter Björquist

    Citation: Clinical and Translational Medicine 2014 3:9

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  6. Content type: Research

    Ventilator-associated pneumonia (VAP) is a leading hospital acquired infection in intensive care units despite improved patient care practices and advancements in endotracheal tube (ETT) designs. The ETT provi...

    Authors: Rhea M May, Matthew G Hoffman, Melinda J Sogo, Albert E Parker, George A O’Toole, Anthony B Brennan and Shravanthi T Reddy

    Citation: Clinical and Translational Medicine 2014 3:8

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  7. Content type: Review

    Biomarker research is continuously expanding in the field of clinical proteomics. A combination of different proteomic–based methodologies can be applied depending on the specific clinical context of use. More...

    Authors: Maria Frantzi, Akshay Bhat and Agnieszka Latosinska

    Citation: Clinical and Translational Medicine 2014 3:7

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  8. Content type: Review

    Recent scientific breakthroughs in stem cell biology suggest that a sustainable treatment approach to cure diabetes mellitus (DM) can be achieved in the near future. However, the transplantation complexities a...

    Authors: Ganesh N Pandian, Junichi Taniguchi and Hiroshi Sugiyama

    Citation: Clinical and Translational Medicine 2014 3:6

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  9. Content type: Commentary

    Tympanic membrane perforations (TMP) are relatively common but are typically not treated in their acute stage, as most will heal spontaneously in 7–10 days. Those cases which fail to heal within 3 months are c...

    Authors: Allen Y Wang, Yi Shen, Jeffrey T Wang, Robert H Eikelboom and Rodney J Dilley

    Citation: Clinical and Translational Medicine 2014 3:5

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  10. Content type: Commentary

    The use of paraffin slides and tissue microarrays (TMA) is indispensable for translational research. However, storage of paraffin slides over time has a substantial detrimental effect on the quality and reliab...

    Authors: Mary Economou, Liliane Schöni, Caroline Hammer, José A Galván, Dominique-Elisabeth Mueller and Inti Zlobec

    Citation: Clinical and Translational Medicine 2014 3:4

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  11. Content type: Review

    Because of the economic growth and changes in lifestyle, metabolic diseases have become a major public health problem, which impose heavy economic burdens on individuals, families and health systems. However, ...

    Authors: Lin Shi, Elena López Villar and Chengshui Chen

    Citation: Clinical and Translational Medicine 2014 3:2

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  12. Content type: Research

    FKBP51 (FKBP5 Official Symbol) is a large molecular weight component of the family of FK506 binding proteins (FKBP). In recent years, research studies from our laboratory highlighted functions for FKBP51 in th...

    Authors: Simona Romano, Anna D’Angelillo, Paolo D’Arrigo, Stefania Staibano, Adelaide Greco, Arturo Brunetti, Massimiliano Scalvenzi, Rita Bisogni, Iris Scala and Maria Fiammetta Romano

    Citation: Clinical and Translational Medicine 2014 3:1

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  13. Content type: Perspective

    Personalized Medicine has the potential to improve health outcomes and reduce the cost of care; however its adoption has been slow in Canada. Bridgepoint Health is a complex continuous care provider striving t...

    Authors: Ruslan Dorfman, Zayna Khayat, Tammy Sieminowski, Brian Golden and Renee Lyons

    Citation: Clinical and Translational Medicine 2013 2:16

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  14. Content type: Research

    Molecular analysis of sputum provides a promising approach for lung cancer diagnosis, yet is limited by the difficulty in collecting the specimens from individuals who can’t spontaneously expectorate sputum. L...

    Authors: Nigar Anjuman, Ning Li, Maria Guarnera, Sanford A Stass and Feng Jiang

    Citation: Clinical and Translational Medicine 2013 2:15

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  15. Content type: Perspective

    Translating the knowledge from biomedical science into clinical applications that help patients has been compared to crossing a valley of death because of the many issues that separate the bench from the bedsi...

    Authors: Eric M Meslin, Alessandro Blasimme and Anne Cambon-Thomsen

    Citation: Clinical and Translational Medicine 2013 2:14

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  16. Content type: Research

    The gaseous headspace above naïve Escherichia Coli (E. coli) cultures and whole human blood inoculated with E. coli were collected and analyzed for the presence of trace gases that may have the potential to be us...

    Authors: Brandon J Umber, Hye-Won Shin, Simone Meinardi, Szu-Yun Leu, Frank Zaldivar, Dan M Cooper and Donald R Blake

    Citation: Clinical and Translational Medicine 2013 2:13

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  17. Content type: Research

    Previous studies of epidermal kinetics in psoriasis have relied on invasive biopsy procedures or the use of radioactive labels. We previously developed a non-invasive method for measuring keratin synthesis in ...

    Authors: Claire L Emson, Sarah Fitzmaurice, Glen Lindwall, Kelvin W Li, Marc K Hellerstein, Howard I Maibach, Wilson Liao and Scott M Turner

    Citation: Clinical and Translational Medicine 2013 2:12

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  18. Content type: Perspective

    Our current health research enterprise is painstakingly slow and cumbersome, and its results seldom translate into practice. The slow pace of health research contributes to findings that are less relevant and ...

    Authors: William T Riley, Russell E Glasgow, Lynn Etheredge and Amy P Abernethy

    Citation: Clinical and Translational Medicine 2013 2:10

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  19. Content type: Review

    Two direct-acting antivirals (DAAs) against hepatitis C virus (HCV): telaprevir and boceprevir, are now available in combination with peginterferon plus ribavirin for the treatment of chronic hepatitis C infec...

    Authors: Tatsuo Kanda, Osamu Yokosuka and Masao Omata

    Citation: Clinical and Translational Medicine 2013 2:9

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  20. Content type: Review

    Maspin (mammary serine protease inhibitor), is a member of the serine protease inhibitor/non-inhibitor superfamily. Its expression is down-regulated in breast, prostate, gastric and melanoma cancers but over-e...

    Authors: Rossana Berardi, Francesca Morgese, Azzurra Onofri, Paola Mazzanti, Mirco Pistelli, Zelmira Ballatore, Agnese Savini, Mariagrazia De Lisa, Miriam Caramanti, Silvia Rinaldi, Silvia Pagliaretta, Matteo Santoni, Chiara Pierantoni and Stefano Cascinu

    Citation: Clinical and Translational Medicine 2013 2:8

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  21. Content type: Research

    The objectives and goals of the Southern Swedish Malignant Melanoma (SSMM)are to develop, build and utilize cutting edge biobanks and OMICS platformsto better understand disease pathology and drug mechanisms. ...

    Authors: Charlotte Welinder, Göran Jönsson, Christian Ingvar, Lotta Lundgren, Håkan Olsson, Thomas Breslin, Ákos Végvári, Thomas Laurell, Melinda Rezeli, Bo Jansson, Bo Baldetorp and György Marko-Varga

    Citation: Clinical and Translational Medicine 2013 2:7

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  22. Content type: Review

    The transplant of organs and tissues is one of the greatest curative achievements of this century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted ti...

    Authors: Batool Mutar Mahdi

    Citation: Clinical and Translational Medicine 2013 2:6

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  23. Content type: Perspective

    We propose A step-by-step roadmap to integrate genetics in the Electronic Patient Record in Family Medicine and clinical research. This could make urgent operationalization of readily available genetic knowled...

    Authors: Elisa JF Houwink, Annet W Sollie, Mattijs E Numans and Martina C Cornel

    Citation: Clinical and Translational Medicine 2013 2:5

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  24. Content type: Review

    Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recur...

    Authors: Lissa Nurrul Abdullah and Edward Kai-Hua Chow

    Citation: Clinical and Translational Medicine 2013 2:3

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  25. Content type: Research

    Accurate stage determination is crucial in the choice of treatment for patients suffering from sleeping sickness, also known as human African trypanosomiasis (HAT). Current staging methods, based on the counti...

    Authors: Natalia Tiberti, Enock Matovu, Alexandre Hainard, John Charles Enyaru, Veerle Lejon, Xavier Robin, Natacha Turck, Dieudonné Mumba Ngoyi, Sanjeev Krishna, Sylvie Bisser, Bertrand Courtioux, Philippe Büscher, Krister Kristensson, Joseph Mathu Ndung'u and Jean-Charles Sanchez

    Citation: Clinical and Translational Medicine 2013 2:1

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  26. Content type: Review

    Oxaliplatin has been a crucial component of combination therapies since admission into the clinic causing modest gains in survival across multiple malignancies. However, oxaliplatin functions in a non-targeted...

    Authors: Osama M Alian, Asfar S Azmi and Ramzi M Mohammad

    Citation: Clinical and Translational Medicine 2012 1:26

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  27. Content type: Short report

    Clinical translational medicine (CTM) is an emerging area comprising multidisciplinary research from basic science to medical applications and entails a close collaboration among hospital, academia and industry.

    Authors: Mengjia Qian, Duojiao Wu, Ena Wang, Francesco M Marincola, Wei Wang, William Rhodes, Michael Liebman, Chunxue Bai, Ching-Wan Lam, Gyorgy Marko-Varga, Thomas E Fehniger, Roland Andersson and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2012 1:25

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  28. Content type: Review

    Stem cells are undifferentiated cells capable of proliferation, self-renewal, and production of a large number of differentiated progeny. Stem cells exist even in malignancies. They are called cancer stem cell...

    Authors: Yasuo Imai, Hidetsugu Yamagishi, Yuko Ono and Yoshihiko Ueda

    Citation: Clinical and Translational Medicine 2012 1:24

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  29. Content type: Research

    HMG-CoA reductase inhibitors (statins) have pleiotropic effects that are independent of cholesterol-lowering, including a dose-dependent effect on angiogenesis. Angiogenesis plays a critical role both in vascu...

    Authors: Will Camnitz, Marie D Burdick, Robert M Strieter, Borna Mehrad and Ellen C Keeley

    Citation: Clinical and Translational Medicine 2012 1:23

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  30. Content type: Editorial

    Health systems globally face challenges and opportunities in balancing quality, access, and cost, where clinical and translational medicine (CTM) should play more important and powerful roles in the identifica...

    Authors: Jiebai Zhou, Duojiao Wu, Xinqing Liu, Shuoqi Yuan, Xiaoqiu Yang and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2012 1:21

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  31. Content type: Review

    Mass Spectrometry (MS)-based phosphoproteomics tools are crucial for understanding the structure and dynamics of signaling networks. Approaches such as affinity purification followed by MS have also been used ...

    Authors: Elena López, Xiangdong Wang, Luis Madero, Juan López-Pascual and Martin Latterich

    Citation: Clinical and Translational Medicine 2012 1:20

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  32. Content type: Research

    Owing to its ease of collection, saliva is potentially the sample of choice in diagnosis. Salivary biomolecules have provided a porthole in surveying a person’s health and well-being. Our study aims were (1) t...

    Authors: Roslinda Mohamed, Jennifer-Leigh Campbell, Justin Cooper-White, Goce Dimeski and Chamindie Punyadeera

    Citation: Clinical and Translational Medicine 2012 1:19

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  33. Content type: Review

    The increasing interest in combined positron emission tomography (PET) and computed tomography (CT) to guide lung cancer radiation therapy planning has been well documented. Motion management strategies during...

    Authors: Stephen R Bowen, Matthew J Nyflot, Michael Gensheimer, Kristi R G Hendrickson, Paul E Kinahan, George A Sandison and Shilpen A Patel

    Citation: Clinical and Translational Medicine 2012 1:18

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  34. Content type: Research

    A great deal of the public’s money has been spent on cancer research but demonstrable benefits to patients have not been proportionate. We are a group of scientists and physicians who several decades ago were ...

    Authors: Michael Retsky, Romano Demicheli, William JM Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Katharine Pachmann and Jayant S Vaidya

    Citation: Clinical and Translational Medicine 2012 1:17

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