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  1. Bone is a preferential site for prostate cancer (PCa) metastasis. However, sites of synchronous distant metastases in PCa patients with bone metastases at initial diagnosis and their impacts on prognosis are s...

    Authors: Feng Zhao, Jili Wang, Meiqin Chen, Danni Chen, Sunyi Ye, Xinke Li, Xin Chen, Guoping Ren and Senxiang Yan

    Citation: Clinical and Translational Medicine 2019 8:30

    Content type: Research

    Published on:

  2. Aberrant expression or hyperactivation of aromatase (CYP19A1)–estrogen receptor (ESR) axis is well identified as one of the major causes of breast cancer. Lots of drugs have been developed for targeting CYP19A...

    Authors: Xing Huang

    Citation: Clinical and Translational Medicine 2019 8:29

    Content type: Commentary

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  3. High-grade serous ovarian cancer (HGSC), the most common ovarian carcinoma type, is associated with the highest mortality rate among all gynecological malignancies. As chemoresistance has been demonstrated as ...

    Authors: Xin Qi, Chunjiang Yu, Yi Wang, Yuxin Lin and Bairong Shen

    Citation: Clinical and Translational Medicine 2019 8:28

    Content type: Research

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  4. The last decade has seen a dramatic increase in the availability of scientific data, where human-related biological databases have grown not only in count but also in volume, posing unprecedented challenges in...

    Authors: Zeeshan Ahmed, Saman Zeeshan, Ruoyun Xiong and Bruce T. Liang

    Citation: Clinical and Translational Medicine 2019 8:26

    Content type: Short report

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  5. Acute respiratory distress syndrome (ARDS) is a life-threatening inflammatory lung condition associated with significant morbidity and mortality. Unfortunately, the current treatment for this disease is mainly...

    Authors: Trushil G. Shah, Dan Predescu and Sanda Predescu

    Citation: Clinical and Translational Medicine 2019 8:25

    Content type: Review

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  6. Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss co...

    Authors: Evgeny Chirshev, Kerby C. Oberg, Yevgeniya J. Ioffe and Juli J. Unternaehrer

    Citation: Clinical and Translational Medicine 2019 8:24

    Content type: Review

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  7. In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular altera...

    Authors: Mariangela Torniai, Laura Scortichini, Francesca Tronconi, Corrado Rubini, Francesca Morgese, Silvia Rinaldi, Paola Mazzanti and Rossana Berardi

    Citation: Clinical and Translational Medicine 2019 8:22

    Content type: Review

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  8. Metastasis is still poorly understood and thus further research must be conducted to provide insight into the driving factors. Novel research has revealed the significance of the microenvironment in the delega...

    Authors: Tovah Williamson, Nikhila Sultanpuram and Hossein Sendi

    Citation: Clinical and Translational Medicine 2019 8:21

    Content type: Review

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  9. Multiple sclerosis (MS) is a common neurological disorder with a variety of manifestations including fatigue. Fatigue may interfere with daily work and activities. Different pharmacological and non-pharmacolog...

    Authors: Mojtaba Khazaei, Ashkan Karevan, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:20

    Content type: Research

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  10. Biological agents have allowed remarkable improvement in controlling autoimmune arthropathies, although none of the numerous biologics readily available represent a universal treatment standard. Moreover, clas...

    Authors: Patrice E. Poubelle, Nathalie Pagé, Marie-Pier Longchamps, Natalia Sampaio Moura, David B. Beck, Ivona Aksentijevich, Philippe A. Tessier and Martin Pelletier

    Citation: Clinical and Translational Medicine 2019 8:19

    Content type: Case report

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  11. Glioblastoma is the most common and malignant brain tumor in adults. Glioblastoma is usually fatal 12–15 months after diagnosis and the current possibilities in therapy are mostly only palliative. Therefore, n...

    Authors: Svenja Busch, Marina Talamini, Steffen Brenner, Amr Abdulazim, Daniel Hänggi, Michael Neumaier, Marcel Seiz-Rosenhagen and Tina Fuchs

    Citation: Clinical and Translational Medicine 2019 8:18

    Content type: Research

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  12. Considering the important role of microbiome, many of current investigations have focused on its beneficial aspects. Although, research explores new dimensions of the impact of microbiome and examines the diff...

    Authors: Ava Behrouzi, Amir Hossein Nafari and Seyed Davar Siadat

    Citation: Clinical and Translational Medicine 2019 8:16

    Content type: Review

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  13. In recent years, large scale genomics and genome-wide studies using comprehensive genomic tools have reshaped our understanding of cancer evolution and heterogeneity. Hepatocellular carcinoma, being one of the...

    Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Citation: Clinical and Translational Medicine 2019 8:13

    Content type: Review

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  14. A positive family history for diabetes, cardiovascular diseases or various types of cancer increases the relative risk for these diseases by 2 to 5 times compared to people without a positive family history. T...

    Authors: Elisa J. F. Houwink, Olga R. Hortensius, Kees van Boven, Annet Sollie and Mattijs E. Numans

    Citation: Clinical and Translational Medicine 2019 8:17

    Content type: Research

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  15. Plasma circulating cell-free (cf) DNA is regarded as a source of tumor DNA. Based on availability of blood tissue for the purposes of early detection of cancer and patients’ follow-up, several studies have eva...

    Authors: Hanifeh Mirtavoos-Mahyari, Soudeh Ghafouri-Fard, Adnan Khosravi, Elahe Motevaseli, Zahra Esfahani-Monfared, Sharareh Seifi, Babak Salimi, Vahid Kholghi Oskooei, Mohsen Ghadami and Mohammad Hossein Modarressi

    Citation: Clinical and Translational Medicine 2019 8:14

    Content type: Research

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  16. Chronic obstructive pulmonary disease (COPD) is expected to climb on the podium of the leading causes of mortality worldwide in the upcoming decade. Clinical diagnosis of COPD has classically relied upon detec...

    Authors: Lukasz A. Myc, Yun M. Shim, Victor E. Laubach and Julien Dimastromatteo

    Citation: Clinical and Translational Medicine 2019 8:12

    Content type: Review

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  17. Multiple sclerosis (MS) is a chronic disease characterized by demyelination, glial activation and axonal degeneration in the central nervous system. At the present, there is no certain remedy for this disease....

    Authors: Mehrdokht Mazdeh, Shahriar Kargar Monhaser, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:11

    Content type: Research

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  18. Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with limited response to cytotoxic chemoradiotherapy, as well as newer immunotherapies. The PDA tumor microenvironment contains infiltrating immune ce...

    Authors: S. K. Daniel, K. M. Sullivan, K. P. Labadie and V. G. Pillarisetty

    Citation: Clinical and Translational Medicine 2019 8:10

    Content type: Review

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  19. There is growing interest in identifying predictive biomarkers for inhibitors of programmed cell death protein 1 receptor (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T-lymphocyte associated protei...

    Authors: Jun Gong, Alexander Chehrazi-Raffle, Veronica Placencio-Hickok, Michelle Guan, Andrew Hendifar and Ravi Salgia

    Citation: Clinical and Translational Medicine 2019 8:9

    Content type: Review

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  20. Nanoparticles have seen considerable popularity as effective tools for drug delivery. However, non-specific targeting continues to remain a challenge. Recently, biomimetic nanoparticles have emerged as an inno...

    Authors: Anna Pasto, Federica Giordano, Michael Evangelopoulos, Alberto Amadori and Ennio Tasciotti

    Citation: Clinical and Translational Medicine 2019 8:8

    Content type: Review

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  21. Although cigarette smoking (CS) is by far the most important risk factor of chronic obstructive pulmonary disease (COPD), repeated and sustained infections are clearly linked to disease pathogenesis and are re...

    Authors: Deviyani M. Rao, Della T. Phan, Michelle J. Choo, Michael R. Weaver, Rebecca E. Oberley-Deegan, Russell P. Bowler and Fabienne Gally

    Citation: Clinical and Translational Medicine 2019 8:7

    Content type: Research

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  22. Patients with transient ischemic attack (TIA) or minor stroke are at risk of strokes. One of the precautionary measures to reduce risk of stroke in these patients is administration of antiplatelet drugs.

    Authors: Mojtaba Khazaei, Fateme Ghasemian, Mehrdokht Mazdeh, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:6

    Content type: Research

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  23. The Editor of this journal has published this Expression of Concern to alert readers that, following publication of the article [1], it came to light that there were undeclared competing interests that have a ...

    Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Citation: Clinical and Translational Medicine 2019 8:5

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Medicine 2016 5:40

  24. This study aims to clarify the prognostic role of epidermal growth factor receptor (EGFR) mutations in plasma of non-small cell lung cancer (NSCLC) for resistance to tyrosine kinase inhibitor (TKI), in correlatio...

    Authors: Thang Thanh Phan, Bich-Thu Tran, Son Truong Nguyen, Toan Trong Ho, Hang Thuy Nguyen, Vu Thuong Le and Anh Tuan Le

    Citation: Clinical and Translational Medicine 2019 8:4

    Content type: Research

    Published on:

  25. Long chain omega-3 fatty acids (omega-3 FAs) supplements have been shown to exert beneficial effects in patients with epilepsy through elevation of seizure thresholds and dampening of inflammatory responses. I...

    Authors: Shaghayegh Omrani, Mohammad Taheri, Mir Davood Omrani, Shahram Arsang-Jang and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2019 8:3

    Content type: Research

    Published on:

  26. Pancreatic cancer is one of the leading causes of cancer-related death in the United States and survival outcomes remain dismal despite significant advances in molecular diagnostics and therapeutics in clinica...

    Authors: Burak Uzunparmak and Ibrahim Halil Sahin

    Citation: Clinical and Translational Medicine 2019 8:2

    Content type: Review

    Published on:

  27. Sjögren’s syndrome (SS) is an autoimmune disease characterized by immune attack on the salivary and lacrimal glands. Given the known cytokine activation and type I interferon gene expression signature found in...

    Authors: Peter D. Burbelo, Sarah Browne, Steve M. Holland, Michael J. Iadarola and Ilias Alevizos

    Citation: Clinical and Translational Medicine 2019 8:1

    Content type: Research

    Published on:

  28. Chronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle‐income countries. Children, w...

    Authors: Rajendra KC, Shakti D. Shukla, Sanjay S. Gautam, Philip M. Hansbro and Ronan F. O’Toole

    Citation: Clinical and Translational Medicine 2018 7:39

    Content type: Review

    Published on:

  29. Multiple sclerosis (MS) is a progressive immune-related disorder of the central nervous system leading to destruction of myelin sheaths. Natalizumab is a humanized monoclonal antibody against the cell adhesion...

    Authors: Mehrdokht Mazdeh, Shno Hosseini, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2018 7:38

    Content type: Research

    Published on:

  30. Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results in breakdown of cartilage in joints and causes the patient to experience intense pain and even disability. The pa...

    Authors: Santul Bapat, Daniel Hubbard, Akul Munjal, Monte Hunter and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2018 7:36

    Content type: Review

    Published on:

  31. Adherence is critical for successful topical, vaginally delivered anti-retroviral (ARV)-based HIV pre-exposure prophylaxis (PrEP). Quantitating systemic or tissue ARV levels through LC–MS/MS is currently viewe...

    Authors: Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Abby G. Peele, Susan Ju, Jill L. Schwartz, Andrea R. Thurman and Gustavo F. Doncel

    Citation: Clinical and Translational Medicine 2018 7:37

    Content type: Research

    Published on:

  32. Cell toxicity may result in organ dysfunction and cause severe health problem. Recent studies revealed many toxicants may induced the over production of Nitric oxide, reactive oxygen species and the subsequent...

    Authors: Yong Zhang

    Citation: Clinical and Translational Medicine 2018 7:34

    Content type: Review

    Published on:

  33. Immune checkpoint inhibitors have demonstrated broad single-agent antitumor activity and a favorable safety profile that render them attractive agents to combine with other systemic anticancer therapies. Pancr...

    Authors: Jun Gong, Andrew Hendifar, Richard Tuli, Jeremy Chuang, May Cho, Vincent Chung, Daneng Li and Ravi Salgia

    Citation: Clinical and Translational Medicine 2018 7:32

    Content type: Review

    Published on:

  34. Human tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that pose major health, social and economic burden at a global level. Current regimens for TB treatment are lengthy, expensi...

    Authors: Naasson Tuyiringire, Deusdedit Tusubira, Jean-Pierre Munyampundu, Casim Umba Tolo, Claude M. Muvunyi and Patrick Engeu Ogwang

    Citation: Clinical and Translational Medicine 2018 7:29

    Content type: Review

    Published on:

  35. Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstra...

    Authors: Hans Raskov, Kasper Nørskov Kragh, Thomas Bjarnsholt, Mahdi Alamili and Ismail Gögenur

    Citation: Clinical and Translational Medicine 2018 7:30

    Content type: Case report

    Published on:

  36. The Editor-in-Chief is retracting this article because the authors have not obtained consent to publish from the patient whose details are described in this case report. The article has been removed to protect...

    Authors: Christopher D. Phillips, Pornpatcharin Wongsaisri, Thein Htut and Terry Grossman

    Citation: Clinical and Translational Medicine 2018 7:31

    Content type: Retraction Note

    Published on:

    The original article was published in Clinical and Translational Medicine 2017 6:31

  37. In low and middle income countries, human immunodeficiency virus (HIV) exposed, uninfected (HEU) infants demonstrate higher morbidity and mortality than their unexposed counterparts. To determine possible immu...

    Authors: Barbara Lohman-Payne, Benjamin Gabriel, Sangshin Park, Dalton Wamalwa, Elizabeth Maleche-Obimbo, Carey Farquhar, Rose Kerubo Bosire and Grace John-Stewart

    Citation: Clinical and Translational Medicine 2018 7:26

    Content type: Research

    Published on:

  38. Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce a...

    Authors: Weilong Chen, Yuanyuan Qin and Suling Liu

    Citation: Clinical and Translational Medicine 2018 7:27

    Content type: Review

    Published on:

  39. HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP...

    Authors: Monique R. Anderson, Michelle L. Pleet, Yoshimi Enose-Akahata, James Erickson, Maria Chiara Monaco, Yao Akpamagbo, Ashley Velluci, Yuetsu Tanaka, Shila Azodi, Ben Lepene, Jennifer Jones, Fatah Kashanchi and Steven Jacobson

    Citation: Clinical and Translational Medicine 2018 7:24

    Content type: Research

    Published on:

  40. We present the Cancer Moonshot clinical project located at the European center in Lund. Here, tissue and blood samples have been collected and stored in a large-scale biobank. Multiple clinical centers around ...

    Authors: Johan Malm, Yutaka Sugihara, Marcell Szasz, Ho Jeong Kwon, Henrik Lindberg, Roger Appelqvist and György Marko-Varga

    Citation: Clinical and Translational Medicine 2018 7:28

    Content type: Research

    Published on:

  41. Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. O...

    Authors: Oleg Dobrokhotov, Mikhail Samsonov, Masahiro Sokabe and Hiroaki Hirata

    Citation: Clinical and Translational Medicine 2018 7:23

    Content type: Review

    Published on:

  42. Currently, only a limited number of molecular biomarkers for malignant melanoma exist. This is the case for both diagnosing the disease, staging, and efficiently measuring the response to therapy by tracing th...

    Authors: Yutaka Sugihara, Daniel Rivas, Johan Malm, Marcell Szasz, HoJeong Kwon, Bo Baldetorp, Håkan Olsson, Christian Ingvar, Melinda Rezeli, Thomas E. Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2018 7:22

    Content type: Research

    Published on:

  43. The prevention, diagnosis and targeted therapies of cancer are important in cancer controlling and treatment. The present challenge about cancer biomarker still remains in identifying the special biomarkers fo...

    Authors: Furong Yan, Hong Zhao and Yiming Zeng

    Citation: Clinical and Translational Medicine 2018 7:21

    Content type: Commentary

    Published on:

  44. Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeut...

    Authors: Paige M. Glumac and Aaron M. LeBeau

    Citation: Clinical and Translational Medicine 2018 7:18

    Content type: Review

    Published on:

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