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  1. Content type: Commentary

    Optimal Independent Review Board (IRB) structure encompasses ongoing process improvement, ethics policies and continuous relationship building, all sound in evidence. With optimal IRB structure, a global resea...

    Authors: Julie Babyar

    Citation: Clinical and Translational Medicine 2018 7:10

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  2. Content type: Research

    Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A—induced proinflammator...

    Authors: Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba and Masanori Emoto

    Citation: Clinical and Translational Medicine 2018 7:9

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  3. Content type: Correction

    In this Correction, the authors would like to acknowledge that the original publication of the article “A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in th...

    Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang

    Citation: Clinical and Translational Medicine 2018 7:8

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    The original article was published in Clinical and Translational Medicine 2016 5:3

  4. Content type: Perspective

    For over six decades reductionist approaches to cancer chemotherapies including recent immunotherapy for solid tumors produced outcome failure-rates of 90% (±5) according to governmental agencies and industry....

    Authors: Hiroshi Maeda and Mahin Khatami

    Citation: Clinical and Translational Medicine 2018 7:11

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  5. Content type: Perspective

    Hereditary diffuse gastric cancer is a cancer predisposition syndrome associated with germline mutations of the E-cadherin gene (CDH1; NM_004360). Male CDH1 germline mutation carriers have by the age of 80 yea...

    Authors: Dandan Li, Winifred Lo and Udo Rudloff

    Citation: Clinical and Translational Medicine 2018 7:7

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  6. Content type: Review

    Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the pro...

    Authors: Steven Bowman, Mohamed E. Awad, Mark W. Hamrick, Monte Hunter and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2018 7:6

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  7. Content type: Research

    Stromal vascular fraction (SVF) represents an attractive source of adult stem cells and progenitors, holding great promise for numerous cell therapy approaches. In 2017, it was reported that 1524 patients rece...

    Authors: Mehmet Okyay Kilinc, Antonio Santidrian, Ivelina Minev, Robert Toth, Dobrin Draganov, Duong Nguyen, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay

    Citation: Clinical and Translational Medicine 2018 7:5

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  8. Content type: Perspective

    Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identif...

    Authors: Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi and Maria Laura Bolognesi

    Citation: Clinical and Translational Medicine 2018 7:3

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  9. Content type: Research

    Recently, non-vitamin K antagonist oral anticoagulants such as direct thrombin and direct factor Xa inhibitors have been prescribed for prevention of embolic stroke. While in Japan, argatroban, also a direct t...

    Authors: Taizen Nakase, Junta Moroi and Tatsuya Ishikawa

    Citation: Clinical and Translational Medicine 2018 7:2

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  10. Content type: Case report

    Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies. Vascular endothelial growth factor-A (VEGF-A) p...

    Authors: Zhichao Liu, Youting Bao, Butuo Li, Xindong Sun and Linlin Wang

    Citation: Clinical and Translational Medicine 2018 7:1

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  11. Content type: Review

    It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environment...

    Authors: Michael A. Ortega, Olivier Poirion, Xun Zhu, Sijia Huang, Thomas K. Wolfgruber, Robert Sebra and Lana X. Garmire

    Citation: Clinical and Translational Medicine 2017 6:46

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  12. Content type: Review

    Extracellular vesicles (EVs) are membranous vesicles released from almost all type of cells including cancer cells. EVs transfer their components, such as microRNAs (miRNAs), messenger RNAs, lipids and protein...

    Authors: Fumihiko Urabe, Nobuyoshi Kosaka, Yusuke Yoshioka, Shin Egawa and Takahiro Ochiya

    Citation: Clinical and Translational Medicine 2017 6:45

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  13. Content type: Review

    Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer c...

    Authors: Stephanie Tran, Peter-Joseph DeGiovanni, Brandon Piel and Prakash Rai

    Citation: Clinical and Translational Medicine 2017 6:44

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  14. Content type: Research

    Monozygotic twins are valuable in assessing the genetic vs environmental contribution to diseases. In the era of complete genome sequences, they allow identification of mutational mechanisms and specific genes...

    Authors: C. A. Castellani, M. G. Melka, J. L. Gui, A. J. Gallo, R. L. O’Reilly and S. M. Singh

    Citation: Clinical and Translational Medicine 2017 6:43

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  15. Content type: Review

    Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in...

    Authors: Sonya Stenfelt, Maria K. E. Blixt, Charlotta All-Ericsson, Finn Hallböök and Henrik Boije

    Citation: Clinical and Translational Medicine 2017 6:42

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  16. Content type: Research

    Nintedanib has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). It was approved by the National Institute for Health and Care Excellence (NICE) in January 2016 for I...

    Authors: Hannah Toellner, G. Hughes, W. Beswick, M. G. Crooks, C. Donaldson, I. Forrest, S. P. Hart, C. Leonard, M. Major, A. J. Simpson and N. Chaudhuri

    Citation: Clinical and Translational Medicine 2017 6:41

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  17. Content type: Short report

    Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic ...

    Authors: Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong and Xu Peng

    Citation: Clinical and Translational Medicine 2017 6:40

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  18. Content type: Research

    Mesenchymal stem cells (MSCs) have broad-spectrum therapeutic effects in various diseases, and thus have many clinical applications. However, it is difficult to produce sufficient numbers of MSCs for clinical ...

    Authors: Wankyu Choi, Soon-Jae Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon and Eun Su Jeon

    Citation: Clinical and Translational Medicine 2017 6:38

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  19. Content type: Research

    Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic ac...

    Authors: Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs and Anton Wellstein

    Citation: Clinical and Translational Medicine 2017 6:37

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  20. Content type: Erratum

    The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Authors: Geeta Shroff

    Citation: Clinical and Translational Medicine 2017 6:36

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    The original article was published in Clinical and Translational Medicine 2016 5:43

  21. Content type: Erratum

    The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Citation: Clinical and Translational Medicine 2017 6:35

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    The original article was published in Clinical and Translational Medicine 2016 5:41

  22. Content type: Research

    Surgery/anesthetic technique-stimulated immunosuppression may be associated with outcome for cancer patients. Here, the immune responses of patients undergoing day surgery versus hospitalization surgery for br...

    Authors: Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Shoichiro Ohtani, Mitsuya Ito, Takayuki Kadoya and Morihito Okada

    Citation: Clinical and Translational Medicine 2017 6:34

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