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  1. Perspective

    A perspective on multi-target drug discovery and design for complex diseases

    Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identif...

    Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi and Maria Laura Bolognesi

    Clinical and Translational Medicine 2018 7:3

    Published on: 17 January 2018

  2. Case report

    Does ALK-rearrangement predict favorable response to the therapy of bevacizumab plus pemetrexed in advanced non-small-cell lung cancer? Case report and literature review

    Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies. Vascular endothelial growth factor-A (VEGF-A) p...

    Zhichao Liu, Youting Bao, Butuo Li, Xindong Sun and Linlin Wang

    Clinical and Translational Medicine 2018 7:1

    Published on: 9 January 2018

  3. Review

    Using single-cell multiple omics approaches to resolve tumor heterogeneity

    It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environment...

    Michael A. Ortega, Olivier Poirion, Xun Zhu, Sijia Huang, Thomas K. Wolfgruber, Robert Sebra and Lana X. Garmire

    Clinical and Translational Medicine 2017 6:46

    Published on: 28 December 2017

  4. Review

    The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

    Extracellular vesicles (EVs) are membranous vesicles released from almost all type of cells including cancer cells. EVs transfer their components, such as microRNAs (miRNAs), messenger RNAs, lipids and protein...

    Fumihiko Urabe, Nobuyoshi Kosaka, Yusuke Yoshioka, Shin Egawa and Takahiro Ochiya

    Clinical and Translational Medicine 2017 6:45

    Published on: 13 December 2017

  5. Review

    Cancer nanomedicine: a review of recent success in drug delivery

    Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer c...

    Stephanie Tran, Peter-Joseph DeGiovanni, Brandon Piel and Prakash Rai

    Clinical and Translational Medicine 2017 6:44

    Published on: 11 December 2017

  6. Research

    Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

    Monozygotic twins are valuable in assessing the genetic vs environmental contribution to diseases. In the era of complete genome sequences, they allow identification of mutational mechanisms and specific genes...

    C. A. Castellani, M. G. Melka, J. L. Gui, A. J. Gallo, R. L. O’Reilly and S. M. Singh

    Clinical and Translational Medicine 2017 6:43

    Published on: 28 November 2017

  7. Review

    Heterogeneity in retinoblastoma: a tale of molecules and models

    Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in...

    Sonya Stenfelt, Maria K. E. Blixt, Charlotta All-Ericsson, Finn Hallböök and Henrik Boije

    Clinical and Translational Medicine 2017 6:42

    Published on: 9 November 2017

  8. Research

    Early clinical experiences with nintedanib in three UK tertiary interstitial lung disease centres

    Nintedanib has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). It was approved by the National Institute for Health and Care Excellence (NICE) in January 2016 for I...

    Hannah Toellner, G. Hughes, W. Beswick, M. G. Crooks, C. Donaldson, I. Forrest, S. P. Hart, C. Leonard, M. Major, A. J. Simpson and N. Chaudhuri

    Clinical and Translational Medicine 2017 6:41

    Published on: 3 November 2017

  9. Short report

    Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia

    Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic ...

    Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong and Xu Peng

    Clinical and Translational Medicine 2017 6:40

    Published on: 3 November 2017

  10. Research

    Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cells

    Mesenchymal stem cells (MSCs) have broad-spectrum therapeutic effects in various diseases, and thus have many clinical applications. However, it is difficult to produce sufficient numbers of MSCs for clinical ...

    Wankyu Choi, Soon-Jae Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon and Eun Su Jeon

    Clinical and Translational Medicine 2017 6:38

    Published on: 10 October 2017

  11. Research

    Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib

    Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic ac...

    Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs and Anton Wellstein

    Clinical and Translational Medicine 2017 6:37

    Published on: 4 October 2017

  12. Erratum

    Expression of Concern to: Evaluation of patients with multiple sclerosis using reverse nutech functional score and expanded disability status scale after human embryonic stem cell therapy

    The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Geeta Shroff

    Clinical and Translational Medicine 2017 6:36

    Published on: 18 September 2017

    The original article was published in Clinical and Translational Medicine 2016 5:43

  13. Erratum

    Expression of Concern to: Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation

    The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Clinical and Translational Medicine 2017 6:35

    Published on: 18 September 2017

    The original article was published in Clinical and Translational Medicine 2016 5:41

  14. Research

    Differences in immune response to anesthetics used for day surgery versus hospitalization surgery for breast cancer patients

    Surgery/anesthetic technique-stimulated immunosuppression may be associated with outcome for cancer patients. Here, the immune responses of patients undergoing day surgery versus hospitalization surgery for br...

    Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Shoichiro Ohtani, Mitsuya Ito, Takayuki Kadoya and Morihito Okada

    Clinical and Translational Medicine 2017 6:34

    Published on: 14 September 2017

  15. Research

    Profiling of cardio-metabolic risk factors and medication utilisation among Type II diabetes patients in Ghana: a prospective cohort study

    Type II diabetes mellitus (T2DM) is complicated by multiple cardio-metabolic risk factors. Controlling these factors requires lifestyle modifications alongside utilisation of anti-diabetic medications. Differe...

    Eric Adua, Peter Roberts, Samuel Asamoah Sakyi, Francis Agyemang Yeboah, Albert Dompreh, Kwasi Frimpong, Enoch Odame Anto and Wei Wang

    Clinical and Translational Medicine 2017 6:32

    Published on: 7 September 2017

  16. Research

    Styrene maleic acid encapsulated raloxifene micelles for management of inflammatory bowel disease

    Inflammatory bowel disease (IBD) comprises a group of disorders that manifest through chronic inflammation of the colon and small intestine. Although the exact cause of IBD is still unclear, dysfunctional immu...

    Khaled Greish, Safa Taha, Anfal Jasim, Sara Abd Elghany, Ameera Sultan, Ali AlKhateeb, Manal Othman, Fang Jun, Sebastien Taurin and Moiz Bakhiet

    Clinical and Translational Medicine 2017 6:28

    Published on: 3 August 2017

  17. Review

    Lipidomics and anti-trypanosomatid chemotherapy

    Trypanosomatids such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi belong to the order Kinetoplastida and are the source of many significant human and animal diseases. Current treatment is unsatisfactor...

    Michael Biagiotti, Sedelia Dominguez, Nader Yamout and Rachel Zufferey

    Clinical and Translational Medicine 2017 6:27

    Published on: 1 August 2017

  18. Research

    CXCL9-11 polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross-sectional study

    CXCL9-11 polymorphisms are related to various infectious diseases, including hepatitis C virus (HCV) infection. In this study, we analyzed the association between CXCL9-11 polymorphism...

    María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Luz Maria Medrano, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, José Saura-Montalban, Sonia Vázquez-Morón, Pablo Ryan and Salvador Resino

    Clinical and Translational Medicine 2017 6:26

    Published on: 28 July 2017

  19. Review

    Significance of long chain polyunsaturated fatty acids in human health

    In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid me...

    Rafael Zárate, Nabil el Jaber-Vazdekis, Noemi Tejera, José A. Pérez and Covadonga Rodríguez

    Clinical and Translational Medicine 2017 6:25

    Published on: 27 July 2017

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