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  1. Content type: Review

    Chronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle‐income countries. Children, w...

    Authors: Rajendra KC, Shakti D. Shukla, Sanjay S. Gautam, Philip M. Hansbro and Ronan F. O’Toole

    Citation: Clinical and Translational Medicine 2018 7:39

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  2. Content type: Research

    Multiple sclerosis (MS) is a progressive immune-related disorder of the central nervous system leading to destruction of myelin sheaths. Natalizumab is a humanized monoclonal antibody against the cell adhesion...

    Authors: Mehrdokht Mazdeh, Shno Hosseini, Mohammad Taheri and Soudeh Ghafouri-Fard

    Citation: Clinical and Translational Medicine 2018 7:38

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  3. Content type: Review

    Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results in breakdown of cartilage in joints and causes the patient to experience intense pain and even disability. The pa...

    Authors: Santul Bapat, Daniel Hubbard, Akul Munjal, Monte Hunter and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2018 7:36

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  4. Content type: Research

    Adherence is critical for successful topical, vaginally delivered anti-retroviral (ARV)-based HIV pre-exposure prophylaxis (PrEP). Quantitating systemic or tissue ARV levels through LC–MS/MS is currently viewe...

    Authors: Terry A. Jacot, Meredith R. Clark, Oluwatosin E. Adedipe, Susan Godbout, Abby G. Peele, Susan Ju, Jill L. Schwartz, Andrea R. Thurman and Gustavo F. Doncel

    Citation: Clinical and Translational Medicine 2018 7:37

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  5. Content type: Review

    Cell toxicity may result in organ dysfunction and cause severe health problem. Recent studies revealed many toxicants may induced the over production of Nitric oxide, reactive oxygen species and the subsequent...

    Authors: Yong Zhang

    Citation: Clinical and Translational Medicine 2018 7:34

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  6. Content type: Review

    Immune checkpoint inhibitors have demonstrated broad single-agent antitumor activity and a favorable safety profile that render them attractive agents to combine with other systemic anticancer therapies. Pancr...

    Authors: Jun Gong, Andrew Hendifar, Richard Tuli, Jeremy Chuang, May Cho, Vincent Chung, Daneng Li and Ravi Salgia

    Citation: Clinical and Translational Medicine 2018 7:32

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  7. Content type: Review

    Human tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that pose major health, social and economic burden at a global level. Current regimens for TB treatment are lengthy, expensi...

    Authors: Naasson Tuyiringire, Deusdedit Tusubira, Jean-Pierre Munyampundu, Casim Umba Tolo, Claude M. Muvunyi and Patrick Engeu Ogwang

    Citation: Clinical and Translational Medicine 2018 7:29

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  8. Content type: Case report

    Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstra...

    Authors: Hans Raskov, Kasper Nørskov Kragh, Thomas Bjarnsholt, Mahdi Alamili and Ismail Gögenur

    Citation: Clinical and Translational Medicine 2018 7:30

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  9. Content type: Retraction Note

    The Editor-in-Chief is retracting this article because the authors have not obtained consent to publish from the patient whose details are described in this case report. The article has been removed to protect...

    Authors: Christopher D. Phillips, Pornpatcharin Wongsaisri, Thein Htut and Terry Grossman

    Citation: Clinical and Translational Medicine 2018 7:31

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    The original article was published in Clinical and Translational Medicine 2017 6:31

  10. Content type: Research

    In low and middle income countries, human immunodeficiency virus (HIV) exposed, uninfected (HEU) infants demonstrate higher morbidity and mortality than their unexposed counterparts. To determine possible immu...

    Authors: Barbara Lohman-Payne, Benjamin Gabriel, Sangshin Park, Dalton Wamalwa, Elizabeth Maleche-Obimbo, Carey Farquhar, Rose Kerubo Bosire and Grace John-Stewart

    Citation: Clinical and Translational Medicine 2018 7:26

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  11. Content type: Review

    Chemotherapy resistance of breast cancer poses a great challenge to the survival of patients. During breast cancer treatment, the development of intrinsic and acquired drug resistance tends to further induce a...

    Authors: Weilong Chen, Yuanyuan Qin and Suling Liu

    Citation: Clinical and Translational Medicine 2018 7:27

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  12. Content type: Research

    HTLV-1 infects over 20 million people worldwide and causes a progressive neuroinflammatory disorder in a subset of infected individuals called HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP...

    Authors: Monique R. Anderson, Michelle L. Pleet, Yoshimi Enose-Akahata, James Erickson, Maria Chiara Monaco, Yao Akpamagbo, Ashley Velluci, Yuetsu Tanaka, Shila Azodi, Ben Lepene, Jennifer Jones, Fatah Kashanchi and Steven Jacobson

    Citation: Clinical and Translational Medicine 2018 7:24

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  13. Content type: Research

    We present the Cancer Moonshot clinical project located at the European center in Lund. Here, tissue and blood samples have been collected and stored in a large-scale biobank. Multiple clinical centers around ...

    Authors: Johan Malm, Yutaka Sugihara, Marcell Szasz, Ho Jeong Kwon, Henrik Lindberg, Roger Appelqvist and György Marko-Varga

    Citation: Clinical and Translational Medicine 2018 7:28

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  14. Content type: Review

    Yes-associated protein (YAP) and its paralog WW domain containing transcription regulator 1 (TAZ) are important regulators of multiple cellular functions such as proliferation, differentiation, and survival. O...

    Authors: Oleg Dobrokhotov, Mikhail Samsonov, Masahiro Sokabe and Hiroaki Hirata

    Citation: Clinical and Translational Medicine 2018 7:23

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  15. Content type: Research

    Currently, only a limited number of molecular biomarkers for malignant melanoma exist. This is the case for both diagnosing the disease, staging, and efficiently measuring the response to therapy by tracing th...

    Authors: Yutaka Sugihara, Daniel Rivas, Johan Malm, Marcell Szasz, HoJeong Kwon, Bo Baldetorp, Håkan Olsson, Christian Ingvar, Melinda Rezeli, Thomas E. Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2018 7:22

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  16. Content type: Commentary

    The prevention, diagnosis and targeted therapies of cancer are important in cancer controlling and treatment. The present challenge about cancer biomarker still remains in identifying the special biomarkers fo...

    Authors: Furong Yan, Hong Zhao and Yiming Zeng

    Citation: Clinical and Translational Medicine 2018 7:21

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  17. Content type: Review

    Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeut...

    Authors: Paige M. Glumac and Aaron M. LeBeau

    Citation: Clinical and Translational Medicine 2018 7:18

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  18. Content type: Perspective

    Maintenance of health involves a synchronized network of catabolic and anabolic signals among organs/tissues/cells that requires differential bioenergetics from mitochondria and glycolysis (biological laws or ...

    Authors: Mahin Khatami

    Citation: Clinical and Translational Medicine 2018 7:20

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  19. Content type: Research

    Pulmonary endothelial cells’ (ECs) injury and apoptotic death are necessary and sufficient for the pathogenesis of the acute respiratory distress syndrome (ARDS), regardless of epithelial damage. Interaction o...

    Authors: Trushil Shah, Shanshan Qin, Mona Vashi, Dan N. Predescu, Niranjan Jeganathan, Cristina Bardita, Balaji Ganesh, Salvatore diBartolo, Louis F. Fogg, Robert A. Balk and Sanda A. Predescu

    Citation: Clinical and Translational Medicine 2018 7:19

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  20. Content type: Research

    Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a ti...

    Authors: Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams III, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T. Ndetan, Karan P. Singh and Steven Idell

    Citation: Clinical and Translational Medicine 2018 7:17

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  21. Content type: Review

    Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like meta...

    Authors: Lillian Truong, Yun-Min Zheng, Tengyao Song, Yi Tang and Yong-Xiao Wang

    Citation: Clinical and Translational Medicine 2018 7:16

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  22. Content type: Research

    Because of its advantage as a minimally invasive procedure, nasal brushings have been increasingly used and proposed as a valuable approach to study lower airway diseases in lieu of bronchial epithelial cells....

    Authors: Nicole Roberts, Reem Al Mubarak, David Francisco, Monica Kraft and Hong Wei Chu

    Citation: Clinical and Translational Medicine 2018 7:13

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  23. Content type: Commentary

    Lipidomics is a measurement of a large scale of lipid species to understand roles of their carbon atoms, dual bonds, or isomerism in the lipid molecule. Clinical lipidomics was recently defined “as a new integ...

    Authors: Jiapei Lv, Linlin Zhang, Furong Yan and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2018 7:12

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  24. Content type: Commentary

    Optimal Independent Review Board (IRB) structure encompasses ongoing process improvement, ethics policies and continuous relationship building, all sound in evidence. With optimal IRB structure, a global resea...

    Authors: Julie Babyar

    Citation: Clinical and Translational Medicine 2018 7:10

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  25. Content type: Research

    Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A—induced proinflammator...

    Authors: Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba and Masanori Emoto

    Citation: Clinical and Translational Medicine 2018 7:9

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  26. Content type: Correction

    In this Correction, the authors would like to acknowledge that the original publication of the article “A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in th...

    Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang

    Citation: Clinical and Translational Medicine 2018 7:8

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    The original article was published in Clinical and Translational Medicine 2016 5:3

  27. Content type: Perspective

    For over six decades reductionist approaches to cancer chemotherapies including recent immunotherapy for solid tumors produced outcome failure-rates of 90% (±5) according to governmental agencies and industry....

    Authors: Hiroshi Maeda and Mahin Khatami

    Citation: Clinical and Translational Medicine 2018 7:11

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  28. Content type: Perspective

    Hereditary diffuse gastric cancer is a cancer predisposition syndrome associated with germline mutations of the E-cadherin gene (CDH1; NM_004360). Male CDH1 germline mutation carriers have by the age of 80 yea...

    Authors: Dandan Li, Winifred Lo and Udo Rudloff

    Citation: Clinical and Translational Medicine 2018 7:7

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  29. Content type: Review

    Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the pro...

    Authors: Steven Bowman, Mohamed E. Awad, Mark W. Hamrick, Monte Hunter and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2018 7:6

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  30. Content type: Research

    Stromal vascular fraction (SVF) represents an attractive source of adult stem cells and progenitors, holding great promise for numerous cell therapy approaches. In 2017, it was reported that 1524 patients rece...

    Authors: Mehmet Okyay Kilinc, Antonio Santidrian, Ivelina Minev, Robert Toth, Dobrin Draganov, Duong Nguyen, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay

    Citation: Clinical and Translational Medicine 2018 7:5

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  31. Content type: Perspective

    Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identif...

    Authors: Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi and Maria Laura Bolognesi

    Citation: Clinical and Translational Medicine 2018 7:3

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  32. Content type: Research

    Recently, non-vitamin K antagonist oral anticoagulants such as direct thrombin and direct factor Xa inhibitors have been prescribed for prevention of embolic stroke. While in Japan, argatroban, also a direct t...

    Authors: Taizen Nakase, Junta Moroi and Tatsuya Ishikawa

    Citation: Clinical and Translational Medicine 2018 7:2

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  33. Content type: Case report

    Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies. Vascular endothelial growth factor-A (VEGF-A) p...

    Authors: Zhichao Liu, Youting Bao, Butuo Li, Xindong Sun and Linlin Wang

    Citation: Clinical and Translational Medicine 2018 7:1

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  34. Content type: Review

    It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environment...

    Authors: Michael A. Ortega, Olivier Poirion, Xun Zhu, Sijia Huang, Thomas K. Wolfgruber, Robert Sebra and Lana X. Garmire

    Citation: Clinical and Translational Medicine 2017 6:46

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  35. Content type: Review

    Extracellular vesicles (EVs) are membranous vesicles released from almost all type of cells including cancer cells. EVs transfer their components, such as microRNAs (miRNAs), messenger RNAs, lipids and protein...

    Authors: Fumihiko Urabe, Nobuyoshi Kosaka, Yusuke Yoshioka, Shin Egawa and Takahiro Ochiya

    Citation: Clinical and Translational Medicine 2017 6:45

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  36. Content type: Review

    Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer c...

    Authors: Stephanie Tran, Peter-Joseph DeGiovanni, Brandon Piel and Prakash Rai

    Citation: Clinical and Translational Medicine 2017 6:44

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  37. Content type: Research

    Monozygotic twins are valuable in assessing the genetic vs environmental contribution to diseases. In the era of complete genome sequences, they allow identification of mutational mechanisms and specific genes...

    Authors: C. A. Castellani, M. G. Melka, J. L. Gui, A. J. Gallo, R. L. O’Reilly and S. M. Singh

    Citation: Clinical and Translational Medicine 2017 6:43

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  38. Content type: Review

    Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in...

    Authors: Sonya Stenfelt, Maria K. E. Blixt, Charlotta All-Ericsson, Finn Hallböök and Henrik Boije

    Citation: Clinical and Translational Medicine 2017 6:42

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  39. Content type: Research

    Nintedanib has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). It was approved by the National Institute for Health and Care Excellence (NICE) in January 2016 for I...

    Authors: Hannah Toellner, G. Hughes, W. Beswick, M. G. Crooks, C. Donaldson, I. Forrest, S. P. Hart, C. Leonard, M. Major, A. J. Simpson and N. Chaudhuri

    Citation: Clinical and Translational Medicine 2017 6:41

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  40. Content type: Short report

    Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic ...

    Authors: Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong and Xu Peng

    Citation: Clinical and Translational Medicine 2017 6:40

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  41. Content type: Research

    Mesenchymal stem cells (MSCs) have broad-spectrum therapeutic effects in various diseases, and thus have many clinical applications. However, it is difficult to produce sufficient numbers of MSCs for clinical ...

    Authors: Wankyu Choi, Soon-Jae Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon and Eun Su Jeon

    Citation: Clinical and Translational Medicine 2017 6:38

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  42. Content type: Research

    Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic ac...

    Authors: Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs and Anton Wellstein

    Citation: Clinical and Translational Medicine 2017 6:37

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