As of 21st February 2020, Clinical and Translational Medicine will cease to consider new submissions with Springer Open. The journal is continuing in cooperation with a new publisher, Wiley. Please contact the Editors-in-Chief for information regarding the new publisher and any submissions in progress. To submit your manuscript to Clinical and Translational Medicine from 21st February 2020, please visit the new submission system at https://mc.manuscriptcentral.com/ctm2. Springer Open will continue to host an archive of all articles previously published in the journal and all articles published in Clinical and Translational Medicine during its time with Springer Open will remain fully searchable via the Springer Open website.