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  1. Content type: Erratum

    The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Authors: Geeta Shroff

    Citation: Clinical and Translational Medicine 2017 6:36

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    The original article was published in Clinical and Translational Medicine 2016 5:43

  2. Content type: Erratum

    The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Citation: Clinical and Translational Medicine 2017 6:35

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    The original article was published in Clinical and Translational Medicine 2016 5:41

  3. Content type: Research

    Surgery/anesthetic technique-stimulated immunosuppression may be associated with outcome for cancer patients. Here, the immune responses of patients undergoing day surgery versus hospitalization surgery for br...

    Authors: Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Shoichiro Ohtani, Mitsuya Ito, Takayuki Kadoya and Morihito Okada

    Citation: Clinical and Translational Medicine 2017 6:34

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  4. Content type: Research

    Type II diabetes mellitus (T2DM) is complicated by multiple cardio-metabolic risk factors. Controlling these factors requires lifestyle modifications alongside utilisation of anti-diabetic medications. Differe...

    Authors: Eric Adua, Peter Roberts, Samuel Asamoah Sakyi, Francis Agyemang Yeboah, Albert Dompreh, Kwasi Frimpong, Enoch Odame Anto and Wei Wang

    Citation: Clinical and Translational Medicine 2017 6:32

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  5. Content type: Research

    Inflammatory bowel disease (IBD) comprises a group of disorders that manifest through chronic inflammation of the colon and small intestine. Although the exact cause of IBD is still unclear, dysfunctional immu...

    Authors: Khaled Greish, Safa Taha, Anfal Jasim, Sara Abd Elghany, Ameera Sultan, Ali AlKhateeb, Manal Othman, Fang Jun, Sebastien Taurin and Moiz Bakhiet

    Citation: Clinical and Translational Medicine 2017 6:28

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  6. Content type: Review

    Trypanosomatids such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi belong to the order Kinetoplastida and are the source of many significant human and animal diseases. Current treatment is unsatisfactor...

    Authors: Michael Biagiotti, Sedelia Dominguez, Nader Yamout and Rachel Zufferey

    Citation: Clinical and Translational Medicine 2017 6:27

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  7. Content type: Research

    CXCL9-11 polymorphisms are related to various infectious diseases, including hepatitis C virus (HCV) infection. In this study, we analyzed the association between CXCL9-11 polymorphism...

    Authors: María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Luz Maria Medrano, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, José Saura-Montalban, Sonia Vázquez-Morón, Pablo Ryan and Salvador Resino

    Citation: Clinical and Translational Medicine 2017 6:26

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  8. Content type: Review

    In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid me...

    Authors: Rafael Zárate, Nabil el Jaber-Vazdekis, Noemi Tejera, José A. Pérez and Covadonga Rodríguez

    Citation: Clinical and Translational Medicine 2017 6:25

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  9. Content type: Review

    Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal degradation pathway. Recently, increasing evidences have...

    Authors: Mengjia Qian, Xiaocong Fang and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2017 6:24

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  10. Content type: Review

    Lipidomics is the identification and quantitation of changes in the lipidome of a cell, tissue, organ or biofluid in health and disease using high resolution mass spectrometry. Lipidome of a particular organis...

    Authors: Arkasubhra Ghosh and Krishnatej Nishtala

    Citation: Clinical and Translational Medicine 2017 6:22

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  11. Content type: Review

    Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network...

    Authors: Raquel Cuevas-Diaz Duran, Haichao Wei and Jia Qian Wu

    Citation: Clinical and Translational Medicine 2017 6:20

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  12. Content type: Review

    Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopathologies and a...

    Authors: Wenli Li and Juergen Pauluhn

    Citation: Clinical and Translational Medicine 2017 6:19

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  13. Content type: Review

    Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress...

    Authors: Chaolei Chen, Xiaomin Huang, Zhaojian Ying, Dengmin Wu, Yani Yu, Xiangdong Wang and Chengshui Chen

    Citation: Clinical and Translational Medicine 2017 6:18

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  14. Content type: Review

    Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to ...

    Authors: Shayan Moazeni, Martin Cadeiras, Eric H. Yang, Mario C. Deng and Kim-Lien Nguyen

    Citation: Clinical and Translational Medicine 2017 6:17

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  15. Content type: Review

    The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, sm...

    Authors: Osamu Tetsu and Frank McCormick

    Citation: Clinical and Translational Medicine 2017 6:16

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  16. Content type: Review

    Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated re...

    Authors: Yves Lecarpentier, Victor Claes, Alexandre Vallée and Jean-Louis Hébert

    Citation: Clinical and Translational Medicine 2017 6:14

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  17. Content type: Review

    Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-...

    Authors: Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth

    Citation: Clinical and Translational Medicine 2017 6:15

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  18. Content type: Commentary

    The ability of salamanders, such as newts, to regenerate damaged tissues has been studied for centuries. A prominent example of this regenerative power is the ability to re-grow entire amputated limbs. One imp...

    Authors: JungIn Um, Da-Woon Jung and Darren Reece Williams

    Citation: Clinical and Translational Medicine 2017 6:13

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  19. Content type: Research

    Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation.

    Authors: George E. Naoum, Zeng B. Zhu, Donald J. Buchsbaum, David T. Curiel and Waleed O. Arafat

    Citation: Clinical and Translational Medicine 2017 6:11

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  20. Content type: Perspective

    As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr...

    Authors: Bruce K. Rubin

    Citation: Clinical and Translational Medicine 2017 6:12

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  21. Content type: Review

    Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se...

    Authors: Jian Wang and Yuanlin Song

    Citation: Clinical and Translational Medicine 2017 6:10

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  22. Content type: Commentary

    Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip...

    Authors: Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake

    Citation: Clinical and Translational Medicine 2017 6:9

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  23. Content type: Research

    The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...

    Authors: Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton

    Citation: Clinical and Translational Medicine 2017 6:5

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  24. Content type: Commentary

    Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm...

    Authors: Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt

    Citation: Clinical and Translational Medicine 2017 6:6

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  25. Content type: Review

    Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional ch...

    Authors: Gabriele D’Errico, Heather L. Machado and Bruno Sainz Jr.

    Citation: Clinical and Translational Medicine 2017 6:3

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  26. Content type: Perspective

    Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

    Authors: William B. Miller Jr. and John S. Torday

    Citation: Clinical and Translational Medicine 2017 6:2

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  27. Content type: Research

    There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

    Authors: Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

    Citation: Clinical and Translational Medicine 2017 6:1

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  28. Content type: Research

    Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

    Authors: Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:44

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  29. Content type: Research

    We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

    Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Citation: Clinical and Translational Medicine 2016 5:40

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  30. Content type: Review

    The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

    Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Citation: Clinical and Translational Medicine 2016 5:41

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    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:35

  31. Content type: Research

    The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be li...

    Authors: Geeta Shroff

    Citation: Clinical and Translational Medicine 2016 5:43

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    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:36

  32. Content type: Research

    Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

    Authors: Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

    Citation: Clinical and Translational Medicine 2016 5:39

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  33. Content type: Research

    Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Authors: Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Citation: Clinical and Translational Medicine 2016 5:37

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  34. Content type: Research

    Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Authors: Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Citation: Clinical and Translational Medicine 2016 5:36

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  35. Content type: Meeting abstracts

    A1 One health advances and successes in comparative medicine and translational research

    Authors: Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. Curiel, Hans Rindt, Carol Reinero, Carolyn J. Henry, Philip J. Bergman, Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha…

    Citation: Clinical and Translational Medicine 2016 5(Suppl 1):26

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    This article is part of a Supplement: Volume 5 Supplement 1

  36. Content type: Research

    High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding of basic mechanisms of liver injury and repair. A metabolite profiling appro...

    Authors: M. Omair Sarfaraz, Robert P. Myers, Carla S. Coffin, Zu-Hua Gao, Abdel Aziz M. Shaheen, Pam M. Crotty, Ping Zhang, Hans J. Vogel and Aalim M. Weljie

    Citation: Clinical and Translational Medicine 2016 5:33

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