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  1. Research

    The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes

    The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...

    Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton

    Clinical and Translational Medicine 2017 6:5

    Published on: 18 January 2017

  2. Commentary

    Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?

    Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm...

    Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt

    Clinical and Translational Medicine 2017 6:6

    Published on: 18 January 2017

  3. Perspective

    A systematic approach to cancer: evolution beyond selection

    Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

    William B. Miller Jr. and John S. Torday

    Clinical and Translational Medicine 2017 6:2

    Published on: 3 January 2017

  4. Research

    MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)

    There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

    Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

    Clinical and Translational Medicine 2017 6:1

    Published on: 2 January 2017

  5. Research

    Novel paradigm for immunotherapy of ovarian cancer by engaging prophylactic immunity against hepatitis B virus

    Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

    Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

    Clinical and Translational Medicine 2016 5:44

    Published on: 30 November 2016

  6. Research

    Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases

    We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

    Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Clinical and Translational Medicine 2016 5:40

    Published on: 20 October 2016

  7. Review

    Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation

    The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

    Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Clinical and Translational Medicine 2016 5:41

    Published on: 20 October 2016

  8. Research

    Serum levels of S100A6 are unaltered in patients with resectable cholangiocarcinoma

    Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

    Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

    Clinical and Translational Medicine 2016 5:39

    Published on: 27 September 2016

  9. Research

    Pharmacokinetics of oseltamivir in infants under the age of 1 year

    Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Clinical and Translational Medicine 2016 5:37

    Published on: 5 September 2016

  10. Research

    JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

    Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Clinical and Translational Medicine 2016 5:36

    Published on: 2 September 2016

  11. Meeting abstracts

    A One Health overview, facilitating advances in comparative medicine and translational research

    A1 One health advances and successes in comparative medicine and translational research

    Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. Curiel, Hans Rindt, Carol Reinero, Carolyn J. Henry, Philip J. Bergman, Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha…

    Clinical and Translational Medicine 2016 5(Suppl 1):26

    Published on: 23 August 2016

    This article is part of a Supplement: Volume 5 Supplement 1

  12. Review

    Therapeutic use of stem cells for cardiovascular disease

    Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their o...

    Whitney Faiella and Rony Atoui

    Clinical and Translational Medicine 2016 5:34

    Published on: 18 August 2016

  13. Research

    A quantitative metabolomics profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis C

    High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding of basic mechanisms of liver injury and repair. A metabolite profiling appro...

    M. Omair Sarfaraz, Robert P. Myers, Carla S. Coffin, Zu-Hua Gao, Abdel Aziz M. Shaheen, Pam M. Crotty, Ping Zhang, Hans J. Vogel and Aalim M. Weljie

    Clinical and Translational Medicine 2016 5:33

    Published on: 18 August 2016

  14. Review

    Creatine kinase in ischemic and inflammatory disorders

    The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a the...

    David Kitzenberg, Sean P. Colgan and Louise E. Glover

    Clinical and Translational Medicine 2016 5:31

    Published on: 15 August 2016

  15. Erratum

    Erratum to: Clinical trial considerations on male contraception and collection of pregnancy information from female partner: update

    Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Clinical and Translational Medicine 2016 5:30

    Published on: 12 August 2016

    The original article was published in Clinical and Translational Medicine 2016 5:23

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