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  1. Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a ti...

    Authors: Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams III, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T. Ndetan, Karan P. Singh and Steven Idell

    Citation: Clinical and Translational Medicine 2018 7:17

    Content type: Research

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  2. Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like meta...

    Authors: Lillian Truong, Yun-Min Zheng, Tengyao Song, Yi Tang and Yong-Xiao Wang

    Citation: Clinical and Translational Medicine 2018 7:16

    Content type: Review

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  3. Because of its advantage as a minimally invasive procedure, nasal brushings have been increasingly used and proposed as a valuable approach to study lower airway diseases in lieu of bronchial epithelial cells....

    Authors: Nicole Roberts, Reem Al Mubarak, David Francisco, Monica Kraft and Hong Wei Chu

    Citation: Clinical and Translational Medicine 2018 7:13

    Content type: Research

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  4. Lipidomics is a measurement of a large scale of lipid species to understand roles of their carbon atoms, dual bonds, or isomerism in the lipid molecule. Clinical lipidomics was recently defined “as a new integ...

    Authors: Jiapei Lv, Linlin Zhang, Furong Yan and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2018 7:12

    Content type: Commentary

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  5. Optimal Independent Review Board (IRB) structure encompasses ongoing process improvement, ethics policies and continuous relationship building, all sound in evidence. With optimal IRB structure, a global resea...

    Authors: Julie Babyar

    Citation: Clinical and Translational Medicine 2018 7:10

    Content type: Commentary

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  6. Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A—induced proinflammator...

    Authors: Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba and Masanori Emoto

    Citation: Clinical and Translational Medicine 2018 7:9

    Content type: Research

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  7. In this Correction, the authors would like to acknowledge that the original publication of the article “A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in th...

    Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang

    Citation: Clinical and Translational Medicine 2018 7:8

    Content type: Correction

    Published on:

    The original article was published in Clinical and Translational Medicine 2016 5:3

  8. For over six decades reductionist approaches to cancer chemotherapies including recent immunotherapy for solid tumors produced outcome failure-rates of 90% (±5) according to governmental agencies and industry....

    Authors: Hiroshi Maeda and Mahin Khatami

    Citation: Clinical and Translational Medicine 2018 7:11

    Content type: Perspective

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  9. Hereditary diffuse gastric cancer is a cancer predisposition syndrome associated with germline mutations of the E-cadherin gene (CDH1; NM_004360). Male CDH1 germline mutation carriers have by the age of 80 yea...

    Authors: Dandan Li, Winifred Lo and Udo Rudloff

    Citation: Clinical and Translational Medicine 2018 7:7

    Content type: Perspective

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  10. Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the pro...

    Authors: Steven Bowman, Mohamed E. Awad, Mark W. Hamrick, Monte Hunter and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2018 7:6

    Content type: Review

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  11. Stromal vascular fraction (SVF) represents an attractive source of adult stem cells and progenitors, holding great promise for numerous cell therapy approaches. In 2017, it was reported that 1524 patients rece...

    Authors: Mehmet Okyay Kilinc, Antonio Santidrian, Ivelina Minev, Robert Toth, Dobrin Draganov, Duong Nguyen, Elliot Lander, Mark Berman, Boris Minev and Aladar A. Szalay

    Citation: Clinical and Translational Medicine 2018 7:5

    Content type: Research

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  12. Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identif...

    Authors: Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi and Maria Laura Bolognesi

    Citation: Clinical and Translational Medicine 2018 7:3

    Content type: Perspective

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  13. Recently, non-vitamin K antagonist oral anticoagulants such as direct thrombin and direct factor Xa inhibitors have been prescribed for prevention of embolic stroke. While in Japan, argatroban, also a direct t...

    Authors: Taizen Nakase, Junta Moroi and Tatsuya Ishikawa

    Citation: Clinical and Translational Medicine 2018 7:2

    Content type: Research

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  14. Advanced ALK-rearranged non-small cell lung cancer (NSCLC) patients will develop acquired resistance after anaplastic lymphoma kinase (ALK) inhibitors therapies. Vascular endothelial growth factor-A (VEGF-A) p...

    Authors: Zhichao Liu, Youting Bao, Butuo Li, Xindong Sun and Linlin Wang

    Citation: Clinical and Translational Medicine 2018 7:1

    Content type: Case report

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  15. It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environment...

    Authors: Michael A. Ortega, Olivier Poirion, Xun Zhu, Sijia Huang, Thomas K. Wolfgruber, Robert Sebra and Lana X. Garmire

    Citation: Clinical and Translational Medicine 2017 6:46

    Content type: Review

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  16. Extracellular vesicles (EVs) are membranous vesicles released from almost all type of cells including cancer cells. EVs transfer their components, such as microRNAs (miRNAs), messenger RNAs, lipids and protein...

    Authors: Fumihiko Urabe, Nobuyoshi Kosaka, Yusuke Yoshioka, Shin Egawa and Takahiro Ochiya

    Citation: Clinical and Translational Medicine 2017 6:45

    Content type: Review

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  17. Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment, the problem is selectively killing all the cancer c...

    Authors: Stephanie Tran, Peter-Joseph DeGiovanni, Brandon Piel and Prakash Rai

    Citation: Clinical and Translational Medicine 2017 6:44

    Content type: Review

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  18. Monozygotic twins are valuable in assessing the genetic vs environmental contribution to diseases. In the era of complete genome sequences, they allow identification of mutational mechanisms and specific genes...

    Authors: C. A. Castellani, M. G. Melka, J. L. Gui, A. J. Gallo, R. L. O’Reilly and S. M. Singh

    Citation: Clinical and Translational Medicine 2017 6:43

    Content type: Research

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  19. Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in...

    Authors: Sonya Stenfelt, Maria K. E. Blixt, Charlotta All-Ericsson, Finn Hallböök and Henrik Boije

    Citation: Clinical and Translational Medicine 2017 6:42

    Content type: Review

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  20. Nintedanib has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). It was approved by the National Institute for Health and Care Excellence (NICE) in January 2016 for I...

    Authors: Hannah Toellner, G. Hughes, W. Beswick, M. G. Crooks, C. Donaldson, I. Forrest, S. P. Hart, C. Leonard, M. Major, A. J. Simpson and N. Chaudhuri

    Citation: Clinical and Translational Medicine 2017 6:41

    Content type: Research

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  21. Cdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic ...

    Authors: Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong and Xu Peng

    Citation: Clinical and Translational Medicine 2017 6:40

    Content type: Short report

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  22. Mesenchymal stem cells (MSCs) have broad-spectrum therapeutic effects in various diseases, and thus have many clinical applications. However, it is difficult to produce sufficient numbers of MSCs for clinical ...

    Authors: Wankyu Choi, Soon-Jae Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon and Eun Su Jeon

    Citation: Clinical and Translational Medicine 2017 6:38

    Content type: Research

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  23. Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic ac...

    Authors: Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs and Anton Wellstein

    Citation: Clinical and Translational Medicine 2017 6:37

    Content type: Research

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  24. The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Authors: Geeta Shroff

    Citation: Clinical and Translational Medicine 2017 6:36

    Content type: Erratum

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    The original article was published in Clinical and Translational Medicine 2016 5:43

  25. The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

    Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Citation: Clinical and Translational Medicine 2017 6:35

    Content type: Erratum

    Published on:

    The original article was published in Clinical and Translational Medicine 2016 5:41

  26. Surgery/anesthetic technique-stimulated immunosuppression may be associated with outcome for cancer patients. Here, the immune responses of patients undergoing day surgery versus hospitalization surgery for br...

    Authors: Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Shoichiro Ohtani, Mitsuya Ito, Takayuki Kadoya and Morihito Okada

    Citation: Clinical and Translational Medicine 2017 6:34

    Content type: Research

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  27. Type II diabetes mellitus (T2DM) is complicated by multiple cardio-metabolic risk factors. Controlling these factors requires lifestyle modifications alongside utilisation of anti-diabetic medications. Differe...

    Authors: Eric Adua, Peter Roberts, Samuel Asamoah Sakyi, Francis Agyemang Yeboah, Albert Dompreh, Kwasi Frimpong, Enoch Odame Anto and Wei Wang

    Citation: Clinical and Translational Medicine 2017 6:32

    Content type: Research

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  28. Inflammatory bowel disease (IBD) comprises a group of disorders that manifest through chronic inflammation of the colon and small intestine. Although the exact cause of IBD is still unclear, dysfunctional immu...

    Authors: Khaled Greish, Safa Taha, Anfal Jasim, Sara Abd Elghany, Ameera Sultan, Ali AlKhateeb, Manal Othman, Fang Jun, Sebastien Taurin and Moiz Bakhiet

    Citation: Clinical and Translational Medicine 2017 6:28

    Content type: Research

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  29. Trypanosomatids such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi belong to the order Kinetoplastida and are the source of many significant human and animal diseases. Current treatment is unsatisfactor...

    Authors: Michael Biagiotti, Sedelia Dominguez, Nader Yamout and Rachel Zufferey

    Citation: Clinical and Translational Medicine 2017 6:27

    Content type: Review

    Published on:

  30. CXCL9-11 polymorphisms are related to various infectious diseases, including hepatitis C virus (HCV) infection. In this study, we analyzed the association between CXCL9-11 polymorphism...

    Authors: María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Luz Maria Medrano, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, José Saura-Montalban, Sonia Vázquez-Morón, Pablo Ryan and Salvador Resino

    Citation: Clinical and Translational Medicine 2017 6:26

    Content type: Research

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  31. In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid me...

    Authors: Rafael Zárate, Nabil el Jaber-Vazdekis, Noemi Tejera, José A. Pérez and Covadonga Rodríguez

    Citation: Clinical and Translational Medicine 2017 6:25

    Content type: Review

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  32. Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal degradation pathway. Recently, increasing evidences have...

    Authors: Mengjia Qian, Xiaocong Fang and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2017 6:24

    Content type: Review

    Published on:

  33. Lipidomics is the identification and quantitation of changes in the lipidome of a cell, tissue, organ or biofluid in health and disease using high resolution mass spectrometry. Lipidome of a particular organis...

    Authors: Arkasubhra Ghosh and Krishnatej Nishtala

    Citation: Clinical and Translational Medicine 2017 6:22

    Content type: Review

    Published on:

  34. Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network...

    Authors: Raquel Cuevas-Diaz Duran, Haichao Wei and Jia Qian Wu

    Citation: Clinical and Translational Medicine 2017 6:20

    Content type: Review

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  35. Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopathologies and a...

    Authors: Wenli Li and Juergen Pauluhn

    Citation: Clinical and Translational Medicine 2017 6:19

    Content type: Review

    Published on:

  36. Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress...

    Authors: Chaolei Chen, Xiaomin Huang, Zhaojian Ying, Dengmin Wu, Yani Yu, Xiangdong Wang and Chengshui Chen

    Citation: Clinical and Translational Medicine 2017 6:18

    Content type: Review

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  37. Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to ...

    Authors: Shayan Moazeni, Martin Cadeiras, Eric H. Yang, Mario C. Deng and Kim-Lien Nguyen

    Citation: Clinical and Translational Medicine 2017 6:17

    Content type: Review

    Published on:

  38. The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, sm...

    Authors: Osamu Tetsu and Frank McCormick

    Citation: Clinical and Translational Medicine 2017 6:16

    Content type: Review

    Published on:

  39. Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-...

    Authors: Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth

    Citation: Clinical and Translational Medicine 2017 6:15

    Content type: Review

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  40. Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated re...

    Authors: Yves Lecarpentier, Victor Claes, Alexandre Vallée and Jean-Louis Hébert

    Citation: Clinical and Translational Medicine 2017 6:14

    Content type: Review

    Published on:

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