Berenbaum F (2013) Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthr Cartil 21(1):16–21
Article
CAS
PubMed
Google Scholar
CDC (2013) Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation—United States, 2010–2012. MMWR 62:869–873
Google Scholar
Barbour K et al (2014) Meeting physical activity guidelines and the risk of incident knee osteoarthritis: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken) 66(1):139–146
Article
CAS
PubMed Central
Google Scholar
Moskowitz RW (2009) The burden of osteoarthritis: clinical and quality-of-life issues. Am J Manag Care 15(8 Suppl):S223–S229
PubMed
Google Scholar
Puig-Junoy J, Ruiz Zamora A (2015) Socio-economic costs of osteoarthritis: a systematic review of cost-of-illness studies. Semin Arthritis Rheum 44(5):531–541
Article
PubMed
Google Scholar
Herrero-Beaumont G et al (2017) Clinical settings in knee osteoarthritis: pathophysiology guides treatment. Maturitas 96:54–57
Article
PubMed
Google Scholar
Zhang W et al (2008) OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16(2):137–162
Article
CAS
PubMed
Google Scholar
Osteoarthritis Fact Sheet (2017) https://www.cdc.gov/arthritis/basics/osteoarthritis.htm. Accessed 24 May 2017
Brosseau L et al (2017) The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part one: introduction, and mind-body exercise programs. Clin Rehabil 31(5):582–595
Article
PubMed
Google Scholar
Brosseau L et al (2017) The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs. Clin Rehabil 31(5):596–611
Article
PubMed
Google Scholar
Brosseau L et al (2017) The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part three: aerobic exercise programs. Clin Rehabil 31(5):612–624
Article
PubMed
Google Scholar
Brien S, Prescott P, Lewith G (2011) Meta-analysis of the related nutritional supplements dimethyl sulfoxide and methylsulfonylmethane in the treatment of osteoarthritis of the knee. Evid Based Complement Alternat Med 2011:528403
PubMed
PubMed Central
Google Scholar
Crofford LJ (2013) Use of NSAIDs in treating patients with arthritis. Arthritis Res Ther 15(Suppl 3):S2
PubMed
PubMed Central
Google Scholar
da Costa BR et al (2016) Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet 387(10033):2093–2105
Article
PubMed
CAS
Google Scholar
Iannitti T, Lodi D, Palmieri B (2011) Intra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acid. Drugs R&D 11(1):13–27
Article
Google Scholar
Balazs EA et al (1967) Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritis human fluids. Arthritis Rheum 10(4):357–376
Article
CAS
PubMed
Google Scholar
Laurent TC, Laurent UB, Fraser JR (1996) The structure and function of hyaluronan: an overview. Immunol Cell Biol 74(2):A1–A7
Article
CAS
PubMed
Google Scholar
Altman RD et al (2015) The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review. BMC Musculoskelet Disord 16:321
Article
CAS
PubMed
PubMed Central
Google Scholar
Ayhan E, Kesmezacar H, Akgun I (2014) Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World J Orthop 5(3):351–361
Article
PubMed
PubMed Central
Google Scholar
Stern R, Jedrzejas MJ (2006) Hyaluronidases: their genomics, structures, and mechanisms of action. Chem Rev 106(3):818–839
Article
CAS
PubMed
PubMed Central
Google Scholar
Oe M et al (2015) Oral hyaluronan relieves knee pain: a review. Nutr J 15:11
Article
CAS
Google Scholar
Moreland LW (2003) Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 5(2):54–67
Article
CAS
PubMed
PubMed Central
Google Scholar
Bannuru RR et al (2011) Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis—meta-analysis. Osteoarthritis Cartilage 19(6):611–619
Article
CAS
PubMed
Google Scholar
Cooper C, Rannou F, Richette P, Bruyère O, Al-Daghri N, Altman RD, Brandi ML, Collaud Basset S, Herrero-Beaumont G, Migliore A, Pavelka K, Uebelhart D, Reginster JY (2017) Use of intraarticular hyaluronic acid in the management of knee osteoarthritis in clinical practice. Arthritis Care Res (Hoboken) 69(9):1287–1296
Article
Google Scholar
Hisada N et al (2008) Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway. Biosci Biotechnol Biochem 72(4):1111–1114
Article
CAS
PubMed
Google Scholar
Asari A, Kanemitsu T, Kurihara H (2010) Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium. J Biol Chem 285(32):24751–24758
Article
CAS
PubMed
PubMed Central
Google Scholar
Tashiro T et al (2012) Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. Sci World J 2012:167928
Article
CAS
Google Scholar
Shewale AR, Barnes CL, Fischbach LA, Ounpraseuth ST, Painter JT, Martin BC (2017) Comparison of low-, moderate-, and high-molecular-weight hyaluronic acid injections in delaying time to knee surgery. J Arthroplasty 32(10):2952–2957.e21
Article
PubMed
Google Scholar
Balazs EA (2004) Viscosupplementation for treatment of osteoarthritis: from initial discovery to current status and results. Surg Technol Int 12:278–289
PubMed
Google Scholar
Bellamy N et al (2006) Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 19(2):Cd005321
Google Scholar
Nguyen C, Rannou F (2017) The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review. Expert Opin Drug Saf 16(8):897–902
Article
CAS
PubMed
Google Scholar
Ricci M et al (2017) Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis. Musculoskelet Surg 101(1):45–49
Article
CAS
PubMed
Google Scholar
Panuccio E, Memeo A, Richetta S (2015) Evaluation of the combined treatment of oral viscosupplementation with hyaluronic acid intra-articular injection on symptomatic knee osteoarthritis. Clin Ter 166(5):e321–e326
CAS
PubMed
Google Scholar
Baier Leach J et al (2003) Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffolds. Biotechnol Bioeng 82(5):578–589
Article
PubMed
CAS
Google Scholar
Xu X et al (2012) Hyaluronic acid-based hydrogels: from a Natural Polysaccharide to Complex Networks. Soft Matter 8(12):3280–3294
Article
CAS
PubMed
PubMed Central
Google Scholar
Fakhari A (2012) Biomedical application of hyaluronic acid nanoparticles. PhD thesis
Burdick JA, Prestwich GD (2011) Hyaluronic acid hydrogels for biomedical applications. Adv Mater 23(12):H41–H56
Article
CAS
PubMed
PubMed Central
Google Scholar
Collins MN, Birkinshaw C (2013) Hyaluronic acid based scaffolds for tissue engineering—A review. Carbohyd Polym 92(2):1262–1279
Article
CAS
Google Scholar
Yoshioka K et al (2014) Pharmacological effects of novel cross-linked hyaluronate, Gel-200, in experimental animal models of osteoarthritis and human cell lines. Osteoarthr Cartil 22(6):879–887
Article
CAS
PubMed
Google Scholar
Sun SF et al (2017) Comparison of single intra-articular injection of novel hyaluronan (HYA-JOINT Plus) with synvisc-one for knee osteoarthritis: a Randomized, Controlled, Double-Blind Trial of Efficacy and Safety. J Bone Joint Surg Am 99(6):462–471
Article
PubMed
Google Scholar
Hangody L et al. Intraarticular injection of a cross-linked sodium hyaluronate combined with triamcinolone hexacetonide (cingal) to provide symptomatic relief of osteoarthritis of the knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial. Cartilage, 2017: 1947603517703732
Park YB et al (2017) Cartilage regeneration in osteoarthritic patients by a composite of allogeneic umbilical cord blood-derived mesenchymal stem cells and hyaluronate hydrogel: results from a clinical trial for safety and proof-of-concept with 7 years of extended follow-Up. Stem Cells Transl Med 6(2):613–621
Article
CAS
PubMed
Google Scholar
Waddell DD, Bricker DC (2007) Total knee replacement delayed with Hylan G-F 20 use in patients with grade IV osteoarthritis. J Manag Care Pharm 13(2):113–121
PubMed
Google Scholar
Altman RD et al (2004) Efficacy and safety of a single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) in patients with osteoarthritis of the knee. Osteoarthr Cartil 12(8):642–649
Article
PubMed
Google Scholar
Lundsgaard C et al (2008) Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial. Scand J Rheumatol 37(2):142–150
Article
CAS
PubMed
Google Scholar
Karatosun V et al (2005) Comparison of two hyaluronan drugs in patients with advanced osteoarthritis of the knee. A prospective, randomized, double-blind study with long term follow-up. Clin Exp Rheumatol 23(2):213–218
CAS
PubMed
Google Scholar
Xing D, Wang B, Liu Q, Ke Y, Xu Y, Li Z, Lin J (2016) Intra-articular hyaluronic acid in treating knee osteoarthritis: a PRISMA-compliant systematic review of overlapping meta-analysis. Sci Rep 6:32790
Article
CAS
PubMed
PubMed Central
Google Scholar
Brandt KD et al (2001) Efficacy and safety of intraarticular sodium hyaluronate in knee osteoarthritis. ORTHOVISC Study Group. Clin Orthop Relat Res 385:130–143
Article
Google Scholar
Day R et al (2004) A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. J Rheumatol 31(4):775–782
CAS
PubMed
Google Scholar
Neustadt D et al (2005) Clinical effects of intraarticular injection of high molecular weight hyaluronan (Orthovisc) in osteoarthritis of the knee: a randomized, controlled, multicenter trial. J Rheumatol 32(10):1928–1936
CAS
PubMed
Google Scholar
Cubukcu D et al (2005) Hylan G-F 20 efficacy on articular cartilage quality in patients with knee osteoarthritis: clinical and MRI assessment. Clin Rheumatol 24(4):336–341
Article
CAS
PubMed
Google Scholar
Petrella RJ, Petrella M (2006) A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee. J Rheumatol 33(5):951–956
CAS
PubMed
Google Scholar
Huskisson EC, Donnelly S (1999) Hyaluronic acid in the treatment of osteoarthritis of the knee. Rheumatology 38(7):602–607
Article
CAS
PubMed
Google Scholar
Altman RD et al (2011) Safety and efficacy of retreatment with a bioengineered hyaluronate for painful osteoarthritis of the knee: results of the open-label Extension Study of the FLEXX Trial. Osteoarthr Cartil 19(10):1169–1175
Article
CAS
PubMed
Google Scholar
Huang TL et al (2011) Intra-articular injections of sodium hyaluronate (Hyalgan(®)) in osteoarthritis of the knee. A randomized, controlled, double-blind, multicenter trial in the asian population. BMC Musculoskelet Disord 12:221
Article
PubMed
PubMed Central
CAS
Google Scholar
Dasa V, DeKoven M, Sun K, Scott A, Lim S (2016) Clinical and cost outcomes from different hyaluronic acid treatments in patients with knee osteoarthritis: evidence from a US health plan claims database. Drugs Context 5:212296
Article
PubMed
PubMed Central
Google Scholar
Battaglia M et al (2013) Efficacy of ultrasound-guided intra-articular injections of platelet-rich plasma versus hyaluronic acid for hip osteoarthritis. Orthopedics 36(12):e1501–e1508
Article
PubMed
Google Scholar
Vad VB et al (2003) Role of hylan G-F 20 in treatment of osteoarthritis of the hip joint. Arch Phys Med Rehabil 84(8):1224–1226
Article
PubMed
Google Scholar
Migliore A et al (2009) Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix(®)) injections versus local anesthetic in osteoarthritis of the hip. Arthritis Res Ther 11(6):R183
Article
PubMed
PubMed Central
CAS
Google Scholar
Piccirilli E et al (2016) Viscosupplementation with intra-articular hyaluronic acid for hip disorders. A systematic review and meta-analysis. Muscles Ligaments Tendons J 6(3):293–299
PubMed
PubMed Central
Google Scholar
Chang KV et al (2013) Effectiveness of intra-articular hyaluronic acid for ankle osteoarthritis treatment: a systematic review and meta-analysis. Arch Phys Med Rehabil 94(5):951–960
Article
PubMed
Google Scholar
Mei-Dan O et al (2013) Intra-articular injections of hyaluronic acid in osteoarthritis of the subtalar joint: a pilot study. J Foot Ankle Surg 52(2):172–176
Article
PubMed
Google Scholar
Rivera F et al (2016) Effectiveness of intra-articular injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis: a multicenter prospective study. J Orthop Traumatol 17(1):27–33
Article
PubMed
Google Scholar
Xin Y et al (2016) The efficacy and safety of sodium hyaluronate injection (Adant(®)) in treating degenerative osteoarthritis: a multi-center, randomized, double-blind, positive-drug parallel-controlled and non-inferiority clinical study. Int J Rheum Dis 19(3):271–278
Article
PubMed
CAS
Google Scholar
Foti C et al (2011) A prospective observational study of the clinical efficacy and safety of intra-articular sodium hyaluronate in synovial joints with osteoarthritis. Eur J Phys Rehabil Med 47(3):407–415
CAS
PubMed
Google Scholar
Migliore A et al (2009) Comparative, double-blind, controlled study of intra-articular hyaluronic acid (Hyalubrix(®)) injections versus local anesthetic in osteoarthritis of the hip. Arthritis Res Ther 11(6):R183–R183
Article
PubMed
PubMed Central
CAS
Google Scholar
Şükür E et al (2016) Comparison of the chondroprotective effect of a novel hydrogel compound and traditional hyaluronate on rat cartilage in a papain-induced osteoarthritis model. Acta Orthopaedica et Traumatologica Turcica 50(4):458–463
Article
PubMed
Google Scholar
Tamura T et al (2016) Novel hyaluronic acid–methotrexate conjugate suppresses joint inflammation in the rat knee: efficacy and safety evaluation in two rat arthritis models. Arthritis Res Ther 18:79
Article
PubMed
PubMed Central
CAS
Google Scholar
Ishikawa M et al (2014) Biocompatibility of cross-linked hyaluronate (Gel-200) for the treatment of knee osteoarthritis. Osteoarthr Cartil 22(11):1902–1909
Article
CAS
PubMed
Google Scholar
Zille H et al (2010) Evaluation of intra-articular delivery of hyaluronic acid functionalized biopolymeric nanoparticles in healthy rat knees. Biomed Mater Eng 20(3):235–242
PubMed
Google Scholar
Morgen M et al (2013) Nanoparticles for improved local retention after intra-articular injection into the knee joint. Pharm Res 30(1):257–268
Article
CAS
PubMed
Google Scholar
McAlindon TE et al (2014) OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage 22(3):363–388
Article
CAS
PubMed
Google Scholar
Hochberg MC et al (2012) American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 64(4):465–474
Article
CAS
Google Scholar
Gigis I et al (2016) Comparison of two different molecular weight intra-articular injections of hyaluronic acid for the treatment of knee osteoarthritis. Hippokratia 20(1):26–31
CAS
PubMed
PubMed Central
Google Scholar
Berg P, Olsson U (2004) Intra-articular injection of non-animal stabilised hyaluronic acid (NASHA) for osteoarthritis of the hip: a pilot study. Clin Exp Rheumatol 22(3):300–306
CAS
PubMed
Google Scholar
Caglar-Yagci H et al (2005) Safety and efficacy of ultrasound-guided intra-articular hylan G-F 20 injection in osteoarthritis of the hip: a pilot study. Rheumatol Int 25(5):341–344
Article
CAS
PubMed
Google Scholar
Tikiz C et al (2005) Comparison of the efficacy of lower and higher molecular weight viscosupplementation in the treatment of hip osteoarthritis. Clin Rheumatol 24(3):244–250
Article
PubMed
Google Scholar
Qvistgaard E et al (2006) Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline. Osteoarthritis Cartilage 14(2):163–170
Article
CAS
PubMed
Google Scholar
Gaston MS, Tiemessen CH, Philips JE (2007) Intra-articular hip viscosupplementation with synthetic hyaluronic acid for osteoarthritis: efficacy, safety and relation to pre-injection radiographs. Arch Orthop Trauma Surg 127(10):899–903
Article
CAS
PubMed
Google Scholar
Rennesson-Rey B, Rat AC, Chary-Valckenaere I, Bettembourg-Brault I, Juge N, Dintinger H, Pourel J, Loeuille D (2008) Does joint effusion influence the clinical response to a single Hylan GF-20 injection for hip osteoarthritis? Joint Bone Spine 75(2):182–188
Article
PubMed
Google Scholar
Richette P et al (2009) Effect of hyaluronic acid in symptomatic hip osteoarthritis: a multicenter, randomized, placebo-controlled trial. Arthritis Rheum 60(3):824–830
Article
CAS
PubMed
Google Scholar
Spitzer AI, Bockow BI, Brander VA, Yates JW, MacCarter DK, Gudger GK, Haller S, Lake SL, Magilavy DB (2010) Hylan G-F 20 improves hip osteoarthritis: a prospective, randomized study. Phys Sportsmed 38(2):35–47
Article
PubMed
Google Scholar
Eyigor C et al (2010) Efficacy of intraarticular hyaluronic acid injection through a lateral approach under fluoroscopic control for advanced hip osteoarthritis. Agri 22(4):139–144
PubMed
Google Scholar
Atchia I et al (2011) Efficacy of a single ultrasound-guided injection for the treatment of hip osteoarthritis. Ann Rheum Dis 70(1):110–116
Article
PubMed
Google Scholar
Dallari D et al (2016) Ultrasound-guided injection of platelet-rich plasma and hyaluronic acid, separately and in combination, for hip osteoarthritis: a Randomized Controlled Study. Am J Sports Med 44(3):664–671
Article
PubMed
Google Scholar
DeGroot H 3rd et al (2012) Intra-articular injection of hyaluronic acid is not superior to saline solution injection for ankle arthritis: a randomized, double-blind, placebo-controlled study. J Bone Joint Surg Am 94(1):2–8
Article
PubMed
Google Scholar
Cohen MM et al (2008) Safety and efficacy of intra-articular sodium hyaluronate (Hyalgan) in a randomized, double-blind study for osteoarthritis of the ankle. Foot Ankle Int 29(7):657–663
Article
PubMed
Google Scholar
Salk RS et al (2006) Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study. J Bone Joint Surg Am 88(2):295–302
PubMed
Google Scholar
Karatosun V et al (2008) Intra-articular hyaluronic acid compared to exercise therapy in osteoarthritis of the ankle. A prospective randomized trial with long-term follow-up. Clin Exp Rheumatol 26(2):288–294
CAS
PubMed
Google Scholar
Carpenter B, Motley T (2008) The role of viscosupplementation in the ankle using hylan G-F 20. J Foot Ankle Surg 47(5):377–384
Article
PubMed
Google Scholar
Sun SF et al (2006) Efficacy of intra-articular hyaluronic acid in patients with osteoarthritis of the ankle: a prospective study. Osteoarthr Cartil 14(9):867–874
Article
PubMed
Google Scholar
Luciani D et al (2008) Viscosupplementation for grade II osteoarthritis of the ankle: a prospective study at 18 months’ follow-up. Chir Organi Mov 92(3):155–160
Article
PubMed
Google Scholar
Witteveen AG et al (2008) A prospective multi-centre, open study of the safety and efficacy of hylan G-F 20 (Synvisc) in patients with symptomatic ankle (talo-crural) osteoarthritis. Foot Ankle Surg 14(3):145–152
Article
PubMed
Google Scholar
Sun SF et al (2011) The effect of 3 weekly intra-articular injections of hyaluronate on pain, function, and balance in patients with unilateral ankle arthritis. J Bone Joint Surg Am 93(18):1720–1726
Article
PubMed
Google Scholar
Grecomoro G, Martorana U, Di Marco C (1987) Intra-articular treatment with sodium hyaluronate in gonarthrosis: a controlled clinical trial versus placebo. Pharmatherapeutica 5(2):137–141
CAS
PubMed
Google Scholar
Puhl W et al (1993) Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study. Osteoarthr Cartil 1(4):233–241
Article
CAS
PubMed
Google Scholar
Henderson EB et al (1994) Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy. Ann Rheum Dis 53(8):529–534
Article
CAS
PubMed
PubMed Central
Google Scholar
Adams ME et al (1995) The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthr Cartil 3(4):213–225
Article
CAS
PubMed
Google Scholar
Lohmander LS et al (1996) Intra-articular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomised, double blind, placebo controlled multicentre trial. Hyaluronan Multicentre Trial Group. Ann Rheum Dis 55(7):424–431
Article
CAS
PubMed
PubMed Central
Google Scholar
Bunyaratavej N, Chan KM, Subramanian N (2001) Treatment of painful osteoarthritis of the knee with hyaluronic acid. Results of a multicenter Asian study. J Med Assoc Thai 84(Suppl 2):S576–S581
PubMed
Google Scholar
Jubb RW et al (2003) A one-year, randomised, placebo (saline) controlled clinical trial of 500–730 kDa sodium hyaluronate (Hyalgan) on the radiological change in osteoarthritis of the knee. Int J Clin Pract 57(6):467–474
CAS
PubMed
Google Scholar
Chevalier X et al (2010) Single, intra-articular treatment with 6 mL hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis 69(1):113–119
Article
CAS
PubMed
Google Scholar
Petrella RJ, DiSilvestro MD, Hildebrand C (2002) Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 162(3):292–298
Article
CAS
PubMed
Google Scholar
Strand V et al (2012) A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee. Osteoarthr Cartil 20(5):350–356
Article
CAS
PubMed
Google Scholar