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  1. We propose A step-by-step roadmap to integrate genetics in the Electronic Patient Record in Family Medicine and clinical research. This could make urgent operationalization of readily available genetic knowled...

    Authors: Elisa JF Houwink, Annet W Sollie, Mattijs E Numans and Martina C Cornel

    Citation: Clinical and Translational Medicine 2013 2:5

    Content type: Perspective

    Published on:

  2. Chemotherapy is one of the standard methods of treatment in many cancers. While chemotherapy is often capable of inducing cell death in tumors and reducing the tumor bulk, many cancer patients experience recur...

    Authors: Lissa Nurrul Abdullah and Edward Kai-Hua Chow

    Citation: Clinical and Translational Medicine 2013 2:3

    Content type: Review

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  3. Accurate stage determination is crucial in the choice of treatment for patients suffering from sleeping sickness, also known as human African trypanosomiasis (HAT). Current staging methods, based on the counti...

    Authors: Natalia Tiberti, Enock Matovu, Alexandre Hainard, John Charles Enyaru, Veerle Lejon, Xavier Robin, Natacha Turck, Dieudonné Mumba Ngoyi, Sanjeev Krishna, Sylvie Bisser, Bertrand Courtioux, Philippe Büscher, Krister Kristensson, Joseph Mathu Ndung'u and Jean-Charles Sanchez

    Citation: Clinical and Translational Medicine 2013 2:1

    Content type: Research

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  4. Oxaliplatin has been a crucial component of combination therapies since admission into the clinic causing modest gains in survival across multiple malignancies. However, oxaliplatin functions in a non-targeted...

    Authors: Osama M Alian, Asfar S Azmi and Ramzi M Mohammad

    Citation: Clinical and Translational Medicine 2012 1:26

    Content type: Review

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  5. Clinical translational medicine (CTM) is an emerging area comprising multidisciplinary research from basic science to medical applications and entails a close collaboration among hospital, academia and industry.

    Authors: Mengjia Qian, Duojiao Wu, Ena Wang, Francesco M Marincola, Wei Wang, William Rhodes, Michael Liebman, Chunxue Bai, Ching-Wan Lam, Gyorgy Marko-Varga, Thomas E Fehniger, Roland Andersson and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2012 1:25

    Content type: Short report

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  6. Stem cells are undifferentiated cells capable of proliferation, self-renewal, and production of a large number of differentiated progeny. Stem cells exist even in malignancies. They are called cancer stem cell...

    Authors: Yasuo Imai, Hidetsugu Yamagishi, Yuko Ono and Yoshihiko Ueda

    Citation: Clinical and Translational Medicine 2012 1:24

    Content type: Review

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  7. HMG-CoA reductase inhibitors (statins) have pleiotropic effects that are independent of cholesterol-lowering, including a dose-dependent effect on angiogenesis. Angiogenesis plays a critical role both in vascu...

    Authors: Will Camnitz, Marie D Burdick, Robert M Strieter, Borna Mehrad and Ellen C Keeley

    Citation: Clinical and Translational Medicine 2012 1:23

    Content type: Research

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  8. Health systems globally face challenges and opportunities in balancing quality, access, and cost, where clinical and translational medicine (CTM) should play more important and powerful roles in the identifica...

    Authors: Jiebai Zhou, Duojiao Wu, Xinqing Liu, Shuoqi Yuan, Xiaoqiu Yang and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2012 1:21

    Content type: Editorial

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  9. Mass Spectrometry (MS)-based phosphoproteomics tools are crucial for understanding the structure and dynamics of signaling networks. Approaches such as affinity purification followed by MS have also been used ...

    Authors: Elena López, Xiangdong Wang, Luis Madero, Juan López-Pascual and Martin Latterich

    Citation: Clinical and Translational Medicine 2012 1:20

    Content type: Review

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  10. Owing to its ease of collection, saliva is potentially the sample of choice in diagnosis. Salivary biomolecules have provided a porthole in surveying a person’s health and well-being. Our study aims were (1) t...

    Authors: Roslinda Mohamed, Jennifer-Leigh Campbell, Justin Cooper-White, Goce Dimeski and Chamindie Punyadeera

    Citation: Clinical and Translational Medicine 2012 1:19

    Content type: Research

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  11. The increasing interest in combined positron emission tomography (PET) and computed tomography (CT) to guide lung cancer radiation therapy planning has been well documented. Motion management strategies during...

    Authors: Stephen R Bowen, Matthew J Nyflot, Michael Gensheimer, Kristi R G Hendrickson, Paul E Kinahan, George A Sandison and Shilpen A Patel

    Citation: Clinical and Translational Medicine 2012 1:18

    Content type: Review

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  12. A great deal of the public’s money has been spent on cancer research but demonstrable benefits to patients have not been proportionate. We are a group of scientists and physicians who several decades ago were ...

    Authors: Michael Retsky, Romano Demicheli, William JM Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Katharine Pachmann and Jayant S Vaidya

    Citation: Clinical and Translational Medicine 2012 1:17

    Content type: Research

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  13. Two risk factors for the development and progression of cancers that are amenable to life style modification are chronic inflammation and the metabolic syndrome. This review proposes two new targets that may m...

    Authors: Mehdi A Fini, Anthony Elias, Richard J Johnson and Richard M Wright

    Citation: Clinical and Translational Medicine 2012 1:16

    Content type: Review

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  14. Supported by the International Society for Translational Medicine (ISTM), Wenzhou Medical College and the First Affiliated Hospital of Wenzhou Medical College, the International Conference on Translational Med...

    Authors: Xiaoming Chen, Roland Andersson, William CS Cho, David Christiani, Richard Coico, Jeffery Drazen, Markus Ege, Thomas Fehniger, Hongwei Gao, Kunlin Jin, Michael N Liebman, Elena Lopez, Giuseppe Marraro, Gyorgy Marko-Varga, Francesco M Marincola, Laurentiu M Popescu…

    Citation: Clinical and Translational Medicine 2012 1:15

    Content type: Short report

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  15. Personalized healthcare holds the promise of ensuring that every patient receives optimal wellness promotion and clinical care based upon his or her unique and multi-factorial phenotype, informed by the most u...

    Authors: Philip R O Payne and Clay B Marsh

    Citation: Clinical and Translational Medicine 2012 1:14

    Content type: Commentary

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  16. Chronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and asthma exert increasing burden on society while the management of them is far from adequate. The objective of this study is t...

    Authors: Xiaocong Fang, Shanqun Li, Lei Gao, Naiqing Zhao, Xiangdong Wang and Chunxue Bai

    Citation: Clinical and Translational Medicine 2012 1:13

    Content type: Research

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  17. Despite major advances in drug development, effective cardiovascular therapies and suitable cardiovascular biomarkers remain limited. The aim of this study was to leverage mass spectrometry (MS) based peptide ...

    Authors: Bing Hui Wang, Simone Reisman, Mark Bailey, Andrew Kompa, Mustafa Ayhan, Henry Krum and Gregory Rice

    Citation: Clinical and Translational Medicine 2012 1:11

    Content type: Research

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  18. For many common global diseases, such as cancer, diabetes, neurodegenerative and cardiovascular diseases there is an unmet need for diagnosing early indications of disease that could enable medical interventio...

    Authors: György Marko-Varga, Ákos Végvári, Melinda Rezeli, Kaiu Prikk, Peeter Ross, Magnus Dahlbäck, Goutham Edula, Ruth Sepper and Thomas E Fehniger

    Citation: Clinical and Translational Medicine 2012 1:8

    Content type: Research

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  19. Severe sepsis is a major concern of public health in industrialized countries. It is estimated that in the United States 200,000-400,000 cases occur annually and resulting in an extensive burden for the health...

    Authors: Markus Bosmann and Peter A Ward

    Citation: Clinical and Translational Medicine 2012 1:4

    Content type: Review

    Published on:

  20. It has been more than a decade that the term "Translational" (medicine, Research, Science) has trickled through the minds of academics, clinicians, business persons, regulators, policy makers, patients and the...

    Authors: Xiangdong Wang and Francesco M Marincola

    Citation: Clinical and Translational Medicine 2012 1:3

    Content type: Editorial

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  21. "It's not what we do, it's the way that we do it". Never has this maxim been truer in proteomics than now. Mass Spectrometry-based proteomics/phosphoproteomics tools are critical to understand the structure an...

    Authors: Elena López, Sarbelio Rodríguez Muñoz, Juan López Pascual and Luis Madero

    Citation: Clinical and Translational Medicine 2012 1:2

    Content type: Short report

    Published on:

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