Brownell J, Polyak SJ: Molecular pathways: hepatitis C virus, CXCL10, and the inflammatory road to liver cancer. Clin Cancer Res 2013. [Epub ahead of print] [Epub ahead of print]
Google Scholar
El-Serag HB: Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 2012, 142: 1264–1273. 10.1053/j.gastro.2011.12.061
Article
PubMed Central
PubMed
Google Scholar
Di Bisceglie AM, Lyra AC, Schwartz M, Reddy RK, Martin P, Gores G, Lok AS, Hussain KB, Gish R, Van Thiel DH, Younossi Z, Tong M, Hassanein T, Balart L, Fleckenstein J, Flamm S, Blei A, Befeler AS, Liver Cancer Network: Hepatitis C-related hepatocellular carcinoma in the United States: influence of ethnic status. Am J Gastroenterol 2003, 98: 2060–2063.
PubMed
Google Scholar
Kanda T, Yokosuka O, Omata M: Hepatitis C virus and hepatocellular carcinoma. Biology 2013, 2: 304–316. 10.3390/biology2010304
Article
PubMed Central
PubMed
Google Scholar
Thomas DL, Seeff LB: Natural history of hepatitis C. Clin Liver Dis 2005, 9: 383–398. 10.1016/j.cld.2005.05.003
Article
PubMed
Google Scholar
Sarin SK, Kumar M: Natural history of HCV infection. Hepatol Int 2012, 6: 684–694. 10.1007/s12072-012-9355-6
Article
PubMed
Google Scholar
Seeff LB: Sustained virologic response: is this equivalent to cure of chronic hepatitis C? Hepatology 2013, 57: 438–440.
Article
PubMed
Google Scholar
Ryder SD, Irving WL, Jones DA, Neal KR, Underwood JC, Treat Hepatitis C Study Group: Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study. Gut 2004, 53: 451–455. 10.1136/gut.2003.021691
Article
PubMed Central
CAS
PubMed
Google Scholar
Barks RE, Ganne-Carrie E, Fontaine H, Paries J, Grando-Lemaire V, Beaugrand M, Pol S, Trinchet JC: Effect of sustained virological response on long-term clinical outcome in 113 patients with compensated hepatitis C-related cirrhosis treated by interferon alpha and ribavirin. World J Gastroenterol 2007, 13: 5648–5653.
Article
Google Scholar
Tsuda N, Yuki N, Mochizuki K, Nagaoka T, Yamashiro M, Omura M, Hikiji K, Kato M: Long-term clinical and virological outcomes of chronic hepatitis C after successful interferon therapy. J Med Virol 2004, 74: 406–413. 10.1002/jmv.20190
Article
CAS
PubMed
Google Scholar
Gentile I, Borgia G: Surrogate endpoints and non-inferiority trials in chronic viral hepatitis. J Hepatol 2010, 52: 778. 10.1016/j.jhep.2009.12.023
Article
PubMed
Google Scholar
Bruno S, Stroffolini T, Colombo M, Bollani S, Benvegnu L, Mazzella G, Ascione A, Santantonio T, Piccinino F, Andreone P, Mangia A, Gaeta GB, Persico M, Faqiuoli S, Almasio PL, Italian Association of the Study of the Liver Disease (AISF): Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study. Hepatology 2007, 45: 579–587. 10.1002/hep.21492
Article
CAS
PubMed
Google Scholar
Ray R: Progress toward development of a hepatitis C vaccine with broad shoulders. Sci Transl Med 2011, 3: 94ps33. 10.1126/scitranslmed.3002772
Article
CAS
PubMed
Google Scholar
Ghany MG, Strader DB, Thomas DL, Seeff LB: Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009, 49: 1335–1374. 10.1002/hep.22759
Article
CAS
PubMed
Google Scholar
European Association for the Study of the Liver: EASL clinical practice guidelines: management of hepatitis C virus infection. J Hepatol 2011, 55: 245–264.
Article
Google Scholar
Omata M, Kanda T, Yu ML, Yokosuka O, Lim SG, Jafri W, Tateishi R, Hamid SS, Chuang WL, Chutaputti A, Wei L, Sollano J, Sarin SK, Kao JH, McCaughan GW: APASL consensus statements and management algorithms for hepatitis C virus infection. Hepatol Int 2012, 55: 409–435.
Article
Google Scholar
Editors of the Drafting Committee for Hepatitis Management Guidelines: The Japan Society of Hepatology: Guidelines for the management of hepatitis virus infection. Hepatol Res 2013, 43: 1–34.
Kanda T, Imazeki F, Yokosuka O: New antiviral therapies for chronic hepatitis C. Hepatol Int 2010, 4: 548–561. 10.1007/s12072-010-9193-3
Article
PubMed Central
PubMed
Google Scholar
Lawitz EJ: Diagnosis and management of telaprevir-associated rash. Gastroenterol Hepatol (N.Y.) 2011, 7: 469–471.
Google Scholar
Tosone G, Borgia G, Gentile I, Cerini R, Conte MC, Orlando R, Piazza M: A case of pegylated interferon alpha-related diabetic ketoacidosis: can this complication be avoided? Acta Diabetol 2007, 44: 167–169. 10.1007/s00592-007-0259-1
Article
CAS
PubMed
Google Scholar
Honda M, Beard MR, Ping LH, Lemon SM: A phylogenetically conserved stem-loop structure at the 5′ border of the internal ribosome entry site of hepatitis C virus is required for cap-independent viral translation. J Virol 1999, 73: 1165–1174.
PubMed Central
CAS
PubMed
Google Scholar
Kanda T, Steele R, Ray R, Ray RB: Small interfering RNA targeted to hepatitis C virus 5′ nontranslated region exerts potent antiviral effect. J Virol 2007, 81: 669–676. 10.1128/JVI.01496-06
Article
PubMed Central
CAS
PubMed
Google Scholar
Poordad F, Dieterich D: Treating hepatitis C: current standard of care and emerging direct-acting antiviral agents. J Viral Hepat 2012, 19: 449–464. 10.1111/j.1365-2893.2012.01617.x
Article
CAS
PubMed
Google Scholar
Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Goncales FL Jr, Haussinger D, Diago M, Carosi G, Dhumeaux D, Caraxi A, Lin A, Hoffman J, Yu J: Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002, 347: 975–982. 10.1056/NEJMoa020047
Article
CAS
PubMed
Google Scholar
Muir AJ, Bornstein JD, Killenberg PG, Atlantic Coast Hepatitis Treatment Group: Peginterferon alfa-2b and ribavirin for the treatment of chronic hepatitis C in blacks and non-Hispanic whites. N Engl J Med 2004, 350: 2265–2271. 10.1056/NEJMoa032502
Article
CAS
PubMed
Google Scholar
Shiffman ML, Suter F, Bacon BR, Nelson D, Harley H, Sola R, Shafran SD, Barange K, Lin A, Soman A, Zeuzem S, ACCELERATE Investigators: Peginterferon alfa-2a and ribavirin for 16 or 24 weeks in HCV genotype 2 or 3. N Engl J Med 2007, 357: 124–134. 10.1056/NEJMoa066403
Article
CAS
PubMed
Google Scholar
Rodriguez-Torres M, Jeffers LJ, Sheikh MY, Rossaro L, Ankoma-Sey V, Hamzeh FM, Martin P, Latino Study Group: Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C. N Engl J Med 2009, 360: 257–267. 10.1056/NEJMoa0805062
Article
CAS
PubMed
Google Scholar
Borgia G, Gentile I, Fortunato G, Borrelli F, Borelli S, de Caterina M, Di Taranto MD, Simone M, Borgia F, Viola C, Reynaud L, Cerini R, Sacchetti L: Homocysteine levels and sustained virological response to pegylated-interferon alpha2b plus ribavirin therapy for chronic hepatitis C: a prospective study. Liver Int 2009, 29: 248–252. 10.1111/j.1478-3231.2008.01832.x
Article
CAS
PubMed
Google Scholar
Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB: Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009, 461: 399–401. 10.1038/nature08309
Article
CAS
PubMed
Google Scholar
Tanaka Y, Nishida N, Sugiyama M, Kuroki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M: Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 2009, 41: 1105–1109. 10.1038/ng.449
Article
CAS
PubMed
Google Scholar
Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, Bassendine M, Spengler U, Dore GJ, Powell E, Riordan S, Sheridan D, Smedile A, Fragomeli V, Muller T, Bahlo M, Stewart GJ, Booth DR, George J: IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009, 41: 1100–1104. 10.1038/ng.447
Article
CAS
PubMed
Google Scholar
Nakamoto S, Kanda T, Imazeki F, Wu S, Arai M, Fujiwara K, Yokosuka O: Simple assay based on restriction fragment length polymorphism associated with IL28B in chronic hepatitis C patients. Scand J Gastroenterol 2011, 46: 955–961. 10.3109/00365521.2011.574731
Article
CAS
PubMed
Google Scholar
Miyamura T, Kanda T, Nakamoto S, Wu S, Fujiwara K, Imazeki F, Yokosuka O: Hepatic STAT1-nuclear translocation and interleukin 28B polymorphisms predict treatment outcomes in hepatitis C virus genotype 1-infected patients. PloS One 2011, 6: e28617. 10.1371/journal.pone.0028617
Article
PubMed Central
CAS
PubMed
Google Scholar
Miyamura T, Kanda T, Nakamoto S, Wu S, Jiang X, Arai M, Fujiwara K, Imazeki F, Yokosuka O: Roles of ITPA and IL28B genotypes in chronic hepatitis C patients treated with peginterferon plus ribavirin. Viruses 2012, 4: 1264–1278. 10.3390/v4081264
Article
PubMed Central
CAS
PubMed
Google Scholar
McHutchison JG, Everson GT, Gordon SC, Jacobson IM, Sulkowski M, Kauffman R, McNair L, Alam J, Muir AJ, PROVE1 Study Team: Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009, 360: 1827–1838. 10.1056/NEJMoa0806104
Article
CAS
PubMed
Google Scholar
Hezode C, Forestier N, Dusheiko G, Ferenci P, Pol S, Goeser T, Bronowicki JP, Bourliere M, Gharakhanian S, Bengtsson L, McNair L, George S, Kieffer T, Kwong A, Kauffman RS, Alam J, Pawlotsky JM, Zeuzem S, PROVE2 Study Team: Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009, 360: 1839–1850. 10.1056/NEJMoa0807650
Article
CAS
PubMed
Google Scholar
McHutchison JG, Manns MP, Muir AJ, Terrault NA, Jacobson IM, Afdhal NH, Heathcote EJ, Zeuzem S, Reesink HW, Garg J, Bsharat M, George S, Kauffman RS, Adda N, Di Bisceglie AM, PROVE3 Study Team: Telaprevir for previously treated chronic HCV infection. N Engl J Med 2010, 362: 1292–1303. 10.1056/NEJMoa0908014
Article
CAS
PubMed
Google Scholar
Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, Marcellin P, Muir AJ, Flisiak R, George J, Rizzetto M, Shouval D, Sola R, Terg RA, Yoshida EM, Adda N, Bengtsson L, Sankoh AJ, Kieffer TL, George S, Kauffman RS, Zeuzem S, ADVANCE Study Team: Telaprevir for previously untreated chronic HCV infection. N Engl J Med 2011, 364: 2405–2416. 10.1056/NEJMoa1012912
Article
CAS
PubMed
Google Scholar
Zeuzem S, Andreone P, Pol S, Lawitz E, Diago M, Roberts S, Focaccia R, Younossi Z, Foster GR, Horban A, Ferenci P, Nevens F, Mullhaupt B, Pockros P, Terg R, Shouval D, van Hoek B, Weiland O, Van Heeswijk R, De Meyer S, Luo D, Boogaerts G, Polo R, Picchio G, Beumont M, REALIZE Study Team: Telaprevir for retreatment of HCV infection. N Engl J Med 2011, 364: 2417–2428. 10.1056/NEJMoa1013086
Article
CAS
PubMed
Google Scholar
Sherman KE, Flamm SL, Afdhal NH, Nelson DR, Sulkowski MS, Everson GT, Fried MW, Adler M, Reesink HW, Martin M, Sankoh AJ, Adda N, Kauffman RS, George S, Wright CI, Poordad F, ILLUMINATE Study Team: Response-guided teraprevir combination treatment for hepatitis C virus infection. N Engl J Med 2011, 365: 1014–1024. 10.1056/NEJMoa1014463
Article
CAS
PubMed
Google Scholar
Poordad F, McCone J Jr, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki JP, SPRINT-2 Investigators: Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011, 364: 1195–1206. 10.1056/NEJMoa1010494
Article
PubMed Central
CAS
PubMed
Google Scholar
Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, Poordad F, Goodman ZD, Sings HL, Boparai N, Burroughs M, Brass CA, Albrecht JK, Esteban R, HCV RESPOND-2 Investigators: Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011, 364: 1207–1217. 10.1056/NEJMoa1009482
Article
PubMed Central
CAS
PubMed
Google Scholar
Lin C, Kwong AD, Perni RB: Discovery and development of VX-950, a novel, covalent, and reversible inhibitor of hepatitis C virus NS3.4A serine protease. Infect Disord Drug Targets 2006, 6: 3–16.
Article
CAS
PubMed
Google Scholar
Gentile I, Viola C, Borgia F, Castaldo G, Borgia G: Telaprevir: a promising protease inhibitor for the treatment of hepatitis C virus infection. Curr Med Chem 2009, 16: 1115–1121. 10.2174/092986709787581789
Article
CAS
PubMed
Google Scholar
Bogen SL, Pan W, Ruan S, Nair LG, Arasappan A, Bennett F, Chen KX, Jao E, Venkatraman S, Liu R, Cheng KC, Guo Z, Tong X, Saksena AK, Girijavallabhan V, Njoroge FG: Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles. J Med Chem 2009, 52: 3679–3688. 10.1021/jm801632a
Article
CAS
PubMed
Google Scholar
Chopra A, Klein PL, Drinnan T, Lee SS: How to optimize HCV therapy in genotype 1 patients: management of side-effects. Liver Int 2013, 33(Suppl 1):30–34.
Article
CAS
PubMed
Google Scholar
Kumada H, Toyoda J, Okanoue T, Chayama K, Tsubouchi H, Hayashi N: Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan. J Hepatol 2012, 56: 78–84. 10.1016/j.jhep.2011.07.016
Article
CAS
PubMed
Google Scholar
Tanwar S, Trembling PM, Dusheiko GM: TMC435 for the treatment of chronic hepatitis C. Expert Opin Investig Drugs 2012, 21: 1193–1209. 10.1517/13543784.2012.690392
Article
CAS
PubMed
Google Scholar
Aerssens J, Fanning F, Scholliers A, Lenz O, Peeters M, De Smedt G, Fried M: Impact of IL28B genotype and pretreatment serum IP-10 in treatment-naive genotype-1 HCV patients treated with TMC435 in combination with peginterferon a-2A and ribavirin in PILLAR Study. J Hepatol 2011, 54(Suppl 1):S5-S6.
Article
Google Scholar
Zeuzem S, Berg T, Gane E, Ferenci P, Foster GR, Fried MW, Hezode C, Hirschfield GM, Jacobson I, Nikitin I, Pockros P, Poordad F, Lenz O, Peeters M, Sekar V, De Smedt G, Beumont-Mauviel M: TMC435 in HCV genotype 1 patients who have failed previous pegylated interferon/ribavirin treatment: final SVR24 results of the ASPIRE TRIAL. J Hepatol 2012, 56(Suppl 2):S1-S2.
Article
Google Scholar
Summa V, Ludmerer SW, McCauley JA, Fandozzi C, Burlein C, Claudio G, Coleman PJ, Dimuzio JM, Ferrara M, Di Filippo M, Gates AT, Graham DJ, Harper S, Hazuda DJ, McHale C, Monteaqudo E, Pucci V, Rowley M, Rudd MT, Soriano A, Stahlhut MW, Vacca JP, Olsen DB, Liverton NJ, Carroll SS: MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother 2012, 56: 4161–4167. 10.1128/AAC.00324-12
Article
PubMed Central
CAS
PubMed
Google Scholar
Zeuzem S, Asselah T, Angus P, Zarski JP, Larrey D, Mullhaupt B, Gane E, Schuchmann M, Lohse A, Pol S, Bronowicki JP, Roberts S, Arasteh K, Zoulim F, Heim M, Stern JO, Kukolj G, Nehmiz G, Haefner C, Boecher WO: Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastroenterology 2011, 141: 2047–2055. 10.1053/j.gastro.2011.08.051
Article
CAS
PubMed
Google Scholar
Cooper C: Hepatitis C treatment highlights from the 2011 American Association for the Study of Liver Disease Meeting. Clin Infect Dis 2012, 55: 418–425. 10.1093/cid/cis375
Article
PubMed
Google Scholar
Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O’Boyle DR 2nd, Lemm JA, Wang C, Knipe JO, Chien C, Colonno RJ, Grasela DM, Meanwell NA, Hamann LG: Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010, 465: 96–100. 10.1038/nature08960
Article
CAS
PubMed
Google Scholar
Pol S, Ghalib RH, Rustgi VH, Martorell C, Everson GT, Tatum HA, Hezode C, Lim JK, Bronowicki JP, Abrams GA, Brau N, Morris DW, Thuluvath PJ, Reindollar RW, Yin PD, Diva U, Hindes R, McPhee F, Hemandez D, Wind-Rotolo M, Hughes EA, Schnittman S: Daclatasvir for previously untreated chronic hepatitis C genotype-1 infection: a randomised, parallel-group, double-blind, placebo-controlled, dose-finding, phase 2a trial. Lancet Infect Dis 2012, 12: 671–677. 10.1016/S1473-3099(12)70138-X
Article
CAS
PubMed
Google Scholar
Barreiro P, Vispo E, Poveda E, Fernandez-Montero JV, Soriano V: Hepatitis C therapy: Highlights from the 2012 annual meeting of the European association for the study of the liver. Clin Infect Dis 2013, 56: 560–566. 10.1093/cid/cis915
Article
PubMed
Google Scholar
Gane EJ, Stedman CA, Hyland RH, Sorensen RD, Symonds WT, Hindes R, Berrey MM: Once daily sofosbuvir (GS-7977) plus ribavirin in patients with HCV genotypes 1, 2, and 3: the ELECTRON trial. Hepatology 2013, 56(suppl):306A.
Google Scholar
Rodriguez-Torres M, Lawitz E, Kowdley KV, Nelson DR, Dejesus E, McHutchison JG, Cornpropst MT, Mader M, Albanis E, Jiang D, Hebner CM, Symonds WT, Berry MM, Lalezari J: Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naive patients with HCV genotype 1: A randomized, 28-day, dose-ranging trial. J Hepatol 2012. [Epub ahead of print] [Epub ahead of print]
Google Scholar
Osinusi A, Heytens L, Lee Y, Bon D, Shivakumar B, Nelson A, Meissner EG, Kohli A, Barrett L, Proschan M, Silk R, Kwan R, Herrmann E, Sneller M, Teferi G, Talwani R, Symonds WT, Polis MA, Mausur H, McHuchison JG, Fauci AS, Kottilil S: High efficacy of GS-7977 in combination with low or full dose ribavirin for 24 weeks in difficult to treat HCV infected genotype 1 patients: interim analysis from SPARE trial. Boston, Massachusetts: Program and abstracts of 63rd Annual Meeting of the American Association for the Study of Liver Diseases; 2012. Abstract LB-4 Abstract LB-4
Google Scholar
Karino Y, Toyoda J, Ikeda K, Suzuki F, Chayama K, Kawakami Y, Ishikawa H, Watanabe H, Hemandez D, Yu F, McPhee F, Kumada H: Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir. J Hepatol 2012. [Epub ahead of print] [Epub ahead of print]
Google Scholar
Suzuki Y, Ikeda K, Suzuki F, Toyoda J, Karino Y, Chayama K, Kawakami Y, Ishikawa H, Watanabe H, Hu W, Eley T, McPhee F, Hughes E, Kumada H: Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options. J Hepatol 2012. [Epub ahead of print] [Epub ahead of print]
Google Scholar
Muir AJ, Poordad FF, McHutchison JG, Shiffman ML, Berg T, Ferenci P, Heathcote EJ, Pawlotsky JM, Zeuzem S, Reesink HW, Dusheiko G, Martin EC, George S, Kauffman RS, Adda N: Retreatment with telaprevir combination therapy in hepatitis C patients with well-characterized prior treatment response. Hepatology 2011, 54: 1538–1546. 10.1002/hep.24549
Article
CAS
PubMed
Google Scholar
Jacobson IM, Pawlotsky JM, Afdhal NH, Dusheiko GM, Forns X, Jensen DM, Poordad F, Schulz J: A practical guide for the use of boceprevir and telaprevir for the treatment of hepatitis C. J Viral Hepat 2012, 19(Suppl 2):1–26.
Article
PubMed
Google Scholar
Lok AS, Gardiner DF, Lawitz E, Martorell C, Everson GT, Ghalib R, Reindollar R, Rustgi V, McPhee F, Wind-Rotolo M, Persson A, Zhu K, Dimitrova DI, Eley T, Guo T, Grasela DM, Pasquinelli C: Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012, 366: 216–224. 10.1056/NEJMoa1104430
Article
CAS
PubMed
Google Scholar
Gane EJ, Stedman CA, Hyland RH, Ding X, Svarovskaia E, Symonds WT, Hindes RG, Berrey MM: Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med 2013, 368: 34–44. 10.1056/NEJMoa1208953
Article
CAS
PubMed
Google Scholar
Herbst DA Jr, Reddy KR: Sofosbuvir, a nucleotide polymerase inhibitor, for the treatment of chronic hepatitis C virus infection. Expert Opin Investig Drugs 2013. [Epub ahead of print] [Epub ahead of print]
Google Scholar
Sulkowski MS, Gardiner DF, Rodriguez-Torres M, Reddy KR, Hassanein T, Jacobson IM, Lawitz E, Lok AS, Hinestrosa F, Thuluvath PJ, Schwartz H, Nelson DR, Eley T, Wind-Rotolo M, Huang SP, Gao M, McPhee F, Sherman D, Hindes R, Symonds WT, Pasquinelli C, Grasela DM: High rate of sustained virologic response with the all-oral combination of daclatasvir (NS5A inhibitor) plus sofosbuvir (nucleotide NS5B inhibitor), with or without ribavirin, in treatment-naive patients chronically infected with HCV genotype 1, 2, or 3. Boston, Massachusetts: Program and abstracts of 63rd Annual Meeting of the American Association for the Study of Liver Diseases; 2012. Abstract LB-2 Abstract LB-2
Google Scholar