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Clinical genomics

  1. Despite the impressive anti-tumor activity of osimertinib in epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC) patients, 30–40% of patients still show limited response. ...

    Authors: Qiufan Zheng, Shaodong Hong, Yan Huang, Hongyun Zhao, Yunpeng Yang, Xue Hou, Yuanyuan Zhao, Yuxiang Ma, Ting Zhou, Yaxiong Zhang, Wenfeng Fang and Li Zhang

    Citation: Clinical and Translational Medicine 2020 9:17

    Content type: Research

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  2. The EGFR-vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming in EGFR-activated GBM has recently been suggested to downregulate the expression of tumour suppressor genes. Histone a...

    Authors: Hongyu Zhao, Yunfei Wang, Chao Yang, Junhu Zhou, Lin Wang, Kaikai Yi, Yansheng Li, Qixue wang, Jin Shi, Chunsheng Kang and Liang Zeng

    Citation: Clinical and Translational Medicine 2020 9:10

    Content type: Research

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  3. The present study sought to identify a panel of DNA markers for noninvasive diagnosis using cell-free DNA (cfDNA) from urine supernatant or cellular DNA from urine sediments of hematuria patients. A panel of 4...

    Authors: Zhenyu Ou, Kai Li, Ting Yang, Ying Dai, Mohan Chandra, Jun Ning, Yongli Wang, Ran Xu, Tangjie Gao, Yu Xie, Qing He, Yuanwei Li, Qin Lu, Long Wang and Zhuo Song

    Citation: Clinical and Translational Medicine 2020 9:4

    Content type: Research

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  4. Bone is a preferential site for prostate cancer (PCa) metastasis. However, sites of synchronous distant metastases in PCa patients with bone metastases at initial diagnosis and their impacts on prognosis are s...

    Authors: Feng Zhao, Jili Wang, Meiqin Chen, Danni Chen, Sunyi Ye, Xinke Li, Xin Chen, Guoping Ren and Senxiang Yan

    Citation: Clinical and Translational Medicine 2019 8:30

    Content type: Research

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  5. The last decade has seen a dramatic increase in the availability of scientific data, where human-related biological databases have grown not only in count but also in volume, posing unprecedented challenges in...

    Authors: Zeeshan Ahmed, Saman Zeeshan, Ruoyun Xiong and Bruce T. Liang

    Citation: Clinical and Translational Medicine 2019 8:26

    Content type: Short report

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  6. Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Authors: Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Citation: Clinical and Translational Medicine 2016 5:18

    Content type: Research

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  7. One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Authors: Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Citation: Clinical and Translational Medicine 2016 5:13

    Content type: Review

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  8. High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architectur...

    Authors: Sunghee Oh, Hong Ji, Drew Barzman, Ping-I Lin and John Hutton

    Citation: Clinical and Translational Medicine 2015 4:37

    Content type: Review

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  9. We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-...

    Authors: Yuchen Sun, Tomomi Furihata, Seiya Ishii, Miki Nagai, Manami Harada, Osamu Shimozato, Takehiko Kamijo, Shinichiro Motohashi, Ichiro Yoshino, Atsuko Kamiichi, Kaoru Kobayashi and Kan Chiba

    Citation: Clinical and Translational Medicine 2014 3:37

    Content type: Research

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  10. Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases...

    Authors: Martin Letzkus, Evert Luesink, Sandrine Starck-Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson and Frank Staedtler

    Citation: Clinical and Translational Medicine 2014 3:36

    Content type: Research

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  11. Personalized Medicine has the potential to improve health outcomes and reduce the cost of care; however its adoption has been slow in Canada. Bridgepoint Health is a complex continuous care provider striving t...

    Authors: Ruslan Dorfman, Zayna Khayat, Tammy Sieminowski, Brian Golden and Renee Lyons

    Citation: Clinical and Translational Medicine 2013 2:16

    Content type: Perspective

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  12. We propose A step-by-step roadmap to integrate genetics in the Electronic Patient Record in Family Medicine and clinical research. This could make urgent operationalization of readily available genetic knowled...

    Authors: Elisa JF Houwink, Annet W Sollie, Mattijs E Numans and Martina C Cornel

    Citation: Clinical and Translational Medicine 2013 2:5

    Content type: Perspective

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