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Clinical genomics

  1. The last decade has seen a dramatic increase in the availability of scientific data, where human-related biological databases have grown not only in count but also in volume, posing unprecedented challenges in...

    Authors: Zeeshan Ahmed, Saman Zeeshan, Ruoyun Xiong and Bruce T. Liang

    Citation: Clinical and Translational Medicine 2019 8:26

    Content type: Short report

    Published on:

  2. Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Authors: Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Citation: Clinical and Translational Medicine 2016 5:18

    Content type: Research

    Published on:

  3. One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Authors: Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Citation: Clinical and Translational Medicine 2016 5:13

    Content type: Review

    Published on:

  4. High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architectur...

    Authors: Sunghee Oh, Hong Ji, Drew Barzman, Ping-I Lin and John Hutton

    Citation: Clinical and Translational Medicine 2015 4:37

    Content type: Review

    Published on:

  5. We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-...

    Authors: Yuchen Sun, Tomomi Furihata, Seiya Ishii, Miki Nagai, Manami Harada, Osamu Shimozato, Takehiko Kamijo, Shinichiro Motohashi, Ichiro Yoshino, Atsuko Kamiichi, Kaoru Kobayashi and Kan Chiba

    Citation: Clinical and Translational Medicine 2014 3:37

    Content type: Research

    Published on:

  6. Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases...

    Authors: Martin Letzkus, Evert Luesink, Sandrine Starck-Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson and Frank Staedtler

    Citation: Clinical and Translational Medicine 2014 3:36

    Content type: Research

    Published on:

  7. Personalized Medicine has the potential to improve health outcomes and reduce the cost of care; however its adoption has been slow in Canada. Bridgepoint Health is a complex continuous care provider striving t...

    Authors: Ruslan Dorfman, Zayna Khayat, Tammy Sieminowski, Brian Golden and Renee Lyons

    Citation: Clinical and Translational Medicine 2013 2:16

    Content type: Perspective

    Published on:

  8. We propose A step-by-step roadmap to integrate genetics in the Electronic Patient Record in Family Medicine and clinical research. This could make urgent operationalization of readily available genetic knowled...

    Authors: Elisa JF Houwink, Annet W Sollie, Mattijs E Numans and Martina C Cornel

    Citation: Clinical and Translational Medicine 2013 2:5

    Content type: Perspective

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    39 days to first decision for all manuscripts
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