Clinical genomics

  1. Research

    Diagnostic yield of array CGH in patients with autism spectrum disorder in Hong Kong

    Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Clinical and Translational Medicine 2016 5:18

    Published on: 16 May 2016

  2. Review

    Genomics, microRNA, epigenetics, and proteomics for future diagnosis, treatment and monitoring response in upper GI cancers

    One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Clinical and Translational Medicine 2016 5:13

    Published on: 6 April 2016

  3. Review

    Pediatric asthma and autism—genomic perspectives

    High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architectur...

    Sunghee Oh, Hong Ji, Drew Barzman, Ping-I Lin and John Hutton

    Clinical and Translational Medicine 2015 4:37

    Published on: 14 December 2015

  4. Research

    Unique expression features of cancer-type organic anion transporting polypeptide 1B3 mRNA expression in human colon and lung cancers

    We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-...

    Yuchen Sun, Tomomi Furihata, Seiya Ishii, Miki Nagai, Manami Harada, Osamu Shimozato, Takehiko Kamijo, Shinichiro Motohashi, Ichiro Yoshino, Atsuko Kamiichi, Kaoru Kobayashi and Kan Chiba

    Clinical and Translational Medicine 2014 3:37

    Published on: 18 November 2014

  5. Research

    Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials

    Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases...

    Martin Letzkus, Evert Luesink, Sandrine Starck-Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson and Frank Staedtler

    Clinical and Translational Medicine 2014 3:36

    Published on: 13 November 2014

  6. Perspective

    Application of personalized medicine to chronic disease: a feasibility assessment

    Personalized Medicine has the potential to improve health outcomes and reduce the cost of care; however its adoption has been slow in Canada. Bridgepoint Health is a complex continuous care provider striving t...

    Ruslan Dorfman, Zayna Khayat, Tammy Sieminowski, Brian Golden and Renee Lyons

    Clinical and Translational Medicine 2013 2:16

    Published on: 18 December 2013