Translational respiratory medicine

  1. Research

    Pharmacokinetics of oseltamivir in infants under the age of 1 year

    Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Clinical and Translational Medicine 2016 5:37

    Published on: 5 September 2016

  2. Research

    JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

    Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Clinical and Translational Medicine 2016 5:36

    Published on: 2 September 2016

  3. Research

    Organizing empyema induced in mice by Streptococcus pneumoniae: effects of plasminogen activator inhibitor-1 deficiency

    Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition...

    Torry A. Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B. Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A. Komissarov, Mitsuo Ikebe and Steven Idell

    Clinical and Translational Medicine 2016 5:17

    Published on: 13 May 2016

  4. Research

    Biomarkers of early chronic obstructive pulmonary disease (COPD) in smokers and former smokers. Protocol of a longitudinal study

    Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD...

    Mikael Truedsson, Johan Malm, K. Barbara Sahlin, May Bugge, Elisabet Wieslander, Magnus Dahlbäck, Roger Appelqvist, Thomas E. Fehniger and György Marko-Varga

    Clinical and Translational Medicine 2016 5:9

    Published on: 7 March 2016

  5. Research

    Randomized trial of acupoints herbal patching in Sanfu Days for asthma in clinical remission stage

    Although China has a long history of using acupoints herbal patching (acupoints herbal patching means applying herbal patch on special acupoints to stimulate skin to form blisters, hyperemia, and even suppurat...

    Libing Zhu, Wei Zhang, Vivian Wong, Ziea Eric, Lixing Lao, Kwaiching Lo, Waichung Chan, To Yau and Lei Li

    Clinical and Translational Medicine 2016 5:5

    Published on: 4 February 2016

  6. Review

    KRAS mutant lung cancer: progress thus far on an elusive therapeutic target

    The KRAS mutation remains the most common driver mutation in patients with non-small cell lung cancer (NSCLC) and confers a poor prognosis. Thus far, efforts to target this mutation over the last two decades have...

    Saveri Bhattacharya, Mark A. Socinski and Timothy F. Burns

    Clinical and Translational Medicine 2015 4:35

    Published on: 14 December 2015

  7. Research

    Long-term effect of respiratory training for chronic obstructive pulmonary disease patients at an outpatient clinic: a randomised controlled trial

    To assess the effect of respiratory training (RT) on lung function, activity tolerance and acute exacerbation frequency with chronic obstructive pulmonary disease (COPD).

    Fang Xi, Zheng Wang, Yong Qi, Richard Brightwell, Peter Roberts, Angus Stewart, Moira Sim and Wei Wang

    Clinical and Translational Medicine 2015 4:31

    Published on: 12 October 2015