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  1. Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Authors: Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Citation: Clinical and Translational Medicine 2016 5:18

    Content type: Research

    Published on:

  2. Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition...

    Authors: Torry A. Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B. Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A. Komissarov, Mitsuo Ikebe and Steven Idell

    Citation: Clinical and Translational Medicine 2016 5:17

    Content type: Research

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  3. Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obst...

    Authors: James D. McCully, Sidney Levitsky, Pedro J. del Nido and Douglas B. Cowan

    Citation: Clinical and Translational Medicine 2016 5:16

    Content type: Review

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  4. The major therapeutic benefit of hydroxyurea, the only FDA-approved pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin (HbF) production that leads to significant red...

    Authors: Gift Dineo Pule, Shaheen Mowla, Nicolas Novitzky and Ambroise Wonkam

    Citation: Clinical and Translational Medicine 2016 5:15

    Content type: Research

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  5. One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Authors: Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Citation: Clinical and Translational Medicine 2016 5:13

    Content type: Review

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  6. Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these add...

    Authors: Ercole L. Cavalieri and Eleanor G. Rogan

    Citation: Clinical and Translational Medicine 2016 5:12

    Content type: Review

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  7. Tamoxifen is used in endocrine treatment of breast cancer to inhibit estrogen signaling. A set of stratified ER-positive and ER-negative tumor sections was subjected to manual deposition of tamoxifen solution ...

    Authors: Ákos Végvári, Alexander S. Shavkunov, Thomas E. Fehniger, Dorthe Grabau, Emma Niméus and György Marko-Varga

    Citation: Clinical and Translational Medicine 2016 5:10

    Content type: Research

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  8. Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD...

    Authors: Mikael Truedsson, Johan Malm, K. Barbara Sahlin, May Bugge, Elisabet Wieslander, Magnus Dahlbäck, Roger Appelqvist, Thomas E. Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2016 5:9

    Content type: Research

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  9. Current debate in type 2 diabetes (T2DM) has focused on shortened leukocyte telomere length (LTL) as the result of a number of possible causes, including polymorphisms in mitochondrial uncoupling proteins (UCP...

    Authors: Yuling Zhou, Zhixin Ning, Yvonne Lee, Brett D. Hambly and Craig S. McLachlan

    Citation: Clinical and Translational Medicine 2016 5:8

    Content type: Review

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  10. Although China has a long history of using acupoints herbal patching (acupoints herbal patching means applying herbal patch on special acupoints to stimulate skin to form blisters, hyperemia, and even suppurat...

    Authors: Libing Zhu, Wei Zhang, Vivian Wong, Ziea Eric, Lixing Lao, Kwaiching Lo, Waichung Chan, To Yau and Lei Li

    Citation: Clinical and Translational Medicine 2016 5:5

    Content type: Research

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  11. Authors: Eric M. Meslin, Joshua B. Rager, Peter H. Schwartz, Kimberly A. Quaid, Margaret M. Gaffney, Jon Duke and William M. Tierney

    Citation: Clinical and Translational Medicine 2016 5:4

    Content type: Erratum

    Published on:

    The original article was published in Clinical and Translational Medicine 2015 4:36

  12. Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in the 1920s, many scientists have tried to further the understanding of tumor bioenergetics. Particu...

    Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang

    Citation: Clinical and Translational Medicine 2016 5:3

    Content type: Review

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    The Correction to this article has been published in Clinical and Translational Medicine 2018 7:8

  13. Anesthesia-induced neurotoxicity research in the developing brain must rely upon an unimpeachable animal model and a standardized treatment approach. In this manner, identification of mechanisms of action may ...

    Authors: Emmett E. Whitaker, Bruno Bissonnette, Andrew D. Miller, Tanner L. Koppert, Joseph D. Tobias, Christopher R. Pierson and Fievos L. Christofi

    Citation: Clinical and Translational Medicine 2016 5:2

    Content type: Research

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  14. Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5 year survival rate of 20–30 %. Various factors have been implicated in the pathogenesis of ACC including dysregulation of the G2/M transition and...

    Authors: Kimberly J. Bussey, Aditi Bapat, Claire Linnehan, Melissa Wandoloski, Erica Dastrup, Erik Rogers, Paul Gonzales and Michael J. Demeure

    Citation: Clinical and Translational Medicine 2016 5:1

    Content type: Research

    Published on:

  15. Application of tumor cell surface adhesion molecule EpCAM-dependent antibody capture, and intracellular cytokeratins (CKs)-dependent immunostaining strategies to detect disseminated or circulating tumor cells ...

    Authors: Peter Ping Lin

    Citation: Clinical and Translational Medicine 2015 4:38

    Content type: Review

    Published on:

    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:6

  16. High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architectur...

    Authors: Sunghee Oh, Hong Ji, Drew Barzman, Ping-I Lin and John Hutton

    Citation: Clinical and Translational Medicine 2015 4:37

    Content type: Review

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  17. Relationships between industry and university-based researchers have been commonplace for decades and have received notable attention concerning the conflicts of interest these relationships may harbor. While ...

    Authors: Eric M. Meslin, Joshua B. Rager, Peter H. Schwartz, Kimberly A. Quaid, Margaret M. Gaffney, Jon Duke and William M. Tierney

    Citation: Clinical and Translational Medicine 2015 4:36

    Content type: Perspective

    Published on:

    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:4

  18. Lung cancer is the most common cancer type worldwide and the leading cause of cancer related deaths in the United States. The majority of newly diagnosed patients present with late stage metastatic lung cancer...

    Authors: Miranda B. Carper and Pier Paolo Claudio

    Citation: Clinical and Translational Medicine 2015 4:33

    Content type: Review

    Published on:

  19. The development of commercially available panels for human blood plasma screening via selected reaction monitoring (SRM) offers reliable, cost-efficient and highly-standardized discovery and validation of prot...

    Authors: Olga I. Kiseleva, Yulia A. Romashova, Natalia E. Moskaleva, Natalia A. Petushkova, Nadezhda B. Teryaeva, Artem Yu. Belyaev and Andrey V. Lisitsa

    Citation: Clinical and Translational Medicine 2015 4:32

    Content type: Short report

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  20. To assess the effect of respiratory training (RT) on lung function, activity tolerance and acute exacerbation frequency with chronic obstructive pulmonary disease (COPD).

    Authors: Fang Xi, Zheng Wang, Yong Qi, Richard Brightwell, Peter Roberts, Angus Stewart, Moira Sim and Wei Wang

    Citation: Clinical and Translational Medicine 2015 4:31

    Content type: Research

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  21. Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease. This has led to an ...

    Authors: Mingyan He, Jinglin Xia, Mohamed Shehab and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2015 4:28

    Content type: Editorial

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  22. In the postgenomic era, it has become evident that analysis of genetic and protein expression changes alone is not sufficient to understand most disease processes in e.g. cardiovascular and cancer disease. Bio...

    Authors: Johan Malm, Henrik Lindberg, David Erlinge, Roger Appelqvist, Maria Yakovleva, Charlotte Welinder, Erik Steinfelder, Thomas E Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2015 4:27

    Content type: Research

    Published on:

  23. Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one poss...

    Authors: Haiyun Wang, Xiaoqi Zheng, Teng Fei, Jinzeng Wang, Xujuan Li, Yin Liu and Fan Zhang

    Citation: Clinical and Translational Medicine 2015 4:25

    Content type: Research

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  24. In the new pathologic classification of lung adenocarcinoma proposed by IASLC/ATS/ERS in 2011, lepidic type adenocarcinomas are constituted by three subtypes; adenocarcinoma in situ (AIS), minimally invasive a...

    Authors: Yasufumi Kato, Haruhiko Nakamura, Hiromasa Tojo, Masaharu Nomura, Toshitaka Nagao, Takeshi Kawamura, Tatsuhiko Kodama, Tatsuo Ohira, Norihiko Ikeda, Thomas Fehniger, György Marko-Varga, Toshihide Nishimura and Harubumi Kato

    Citation: Clinical and Translational Medicine 2015 4:24

    Content type: Research article

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  25. Despite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic fac...

    Authors: Wei Chen and Lorraine B Ware

    Citation: Clinical and Translational Medicine 2015 4:23

    Content type: Review

    Published on:

  26. Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and infl...

    Authors: Li Ma, Ciara M. Shaver, Brandon S. Grove, Daphne B. Mitchell, Nancy E. Wickersham, Robert H. Carnahan, Tracy L. Cooper, Brittany E. Brake, Lorraine B. Ware and Julie A. Bastarache

    Citation: Clinical and Translational Medicine 2015 4:22

    Content type: Research article

    Published on:

  27. As the high throughput sequencing efforts generate more biological information, scientists from different disciplines are interpreting the polymorphisms that make us unique. In addition, there is an increasing...

    Authors: Timo Tiirikka and Jukka S Moilanen

    Citation: Clinical and Translational Medicine 2015 4:20

    Content type: Research

    Published on:

  28. In spite of the implementations of several strategies, tuberculosis (TB) is overwhelmingly a serious global public health problem causing millions of infections and deaths every year. This is mainly due to the...

    Authors: Tilahun Melak and Sunita Gakkhar

    Citation: Clinical and Translational Medicine 2015 4:19

    Content type: Research article

    Published on:

  29. The activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation and survival, is orchestrated by protein kinases via phosphorylation. A critical i...

    Authors: Elena López Villar, Luis Madero, Juan A López-Pascual and William C Cho

    Citation: Clinical and Translational Medicine 2015 4:18

    Content type: Commentary

    Published on:

  30. To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in a Cameroonian population.

    Authors: Dieudonne Nanfa, Eugene Sobngwi, Barbara Atogho-Tiedeu, Jean Jacques N Noubiap, Olivier Sontsa Donfack, Edith Pascale Mato Mofo, Magellan Guewo-Fokeng, Aurelie Nguimmo Metsadjio, Elvis Ndonwi Ngwa, Priscille Pokam Fosso, Eric Djahmeni, Rosine Djokam-Dadjeu, Marie-Solange Evehe, Folefac Aminkeng, Wilfred F Mbacham and Jean Claude Mbanya

    Citation: Clinical and Translational Medicine 2015 4:17

    Content type: Research

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  31. Fine needle aspiration (FNA) biopsy plays a critical role in the diagnosis and staging of lung primary and metastatic lung carcinoma. Accurate subclassification of adenocarcinoma (ADC) and/or squamous cell car...

    Authors: Grzegorz T Gurda, Lei Zhang, Yuting Wang, Li Chen, Susan Geddes, William C Cho, Frederic Askin, Edward Gabrielson and Qing Kay Li

    Citation: Clinical and Translational Medicine 2015 4:16

    Content type: Research

    Published on:

  32. Graduate medical education has traditionally focused on training future physicians to be outstanding clinicians with basic and clinical science research skills. This focus has resulted in substantial knowledge...

    Authors: Patrick D Loftus, Craig T Elder, Troy D’Ambrosio and John T Langell

    Citation: Clinical and Translational Medicine 2015 4:15

    Content type: Perspective

    Published on:

  33. Epithelial mesenchymal transition (EMT) is a physiological process necessary to normal embryologic development. However in genesis of pathological situations, this transition can be perverted and signaling pat...

    Authors: Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri and Michel Rigaud

    Citation: Clinical and Translational Medicine 2015 4:14

    Content type: Review

    Published on:

  34. Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited...

    Authors: William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston and Johann E Gudjonsson

    Citation: Clinical and Translational Medicine 2015 4:13

    Content type: Research

    Published on:

  35. Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implic...

    Authors: Ranjit Ganguly, Ahmed Mohyeldin, Jordyn Thiel, Harley I Kornblum, Monique Beullens and Ichiro Nakano

    Citation: Clinical and Translational Medicine 2015 4:11

    Content type: Review

    Published on:

  36. Low grade gliomas are the most common brain tumor in children. Tandem duplication involving the KIAA1549 and the BRAF kinase genes results in a gene fusion that has been recently characterized in a subset of low ...

    Authors: Hala Taha, Maha Yehia, Madeha Mahmoud, Mohamed El-Beltagy, Myret Ghabriel and Shahenda El-Naggar

    Citation: Clinical and Translational Medicine 2015 4:10

    Content type: Research

    Published on:

  37. Catheter-related bloodstream infections (CRBSIs) and catheter-related thrombosis (CRT) are common complications of central venous catheters (CVC), which are used to monitor patient health and deliver medicatio...

    Authors: Rhea M May, Chelsea M Magin, Ethan E Mann, Michael C Drinker, John C Fraser, Christopher A Siedlecki, Anthony B Brennan and Shravanthi T Reddy

    Citation: Clinical and Translational Medicine 2015 4:9

    Content type: Research

    Published on:

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