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  1. Content type: Research

    Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5 year survival rate of 20–30 %. Various factors have been implicated in the pathogenesis of ACC including dysregulation of the G2/M transition and...

    Authors: Kimberly J. Bussey, Aditi Bapat, Claire Linnehan, Melissa Wandoloski, Erica Dastrup, Erik Rogers, Paul Gonzales and Michael J. Demeure

    Citation: Clinical and Translational Medicine 2016 5:1

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  2. Content type: Review

    Application of tumor cell surface adhesion molecule EpCAM-dependent antibody capture, and intracellular cytokeratins (CKs)-dependent immunostaining strategies to detect disseminated or circulating tumor cells ...

    Authors: Peter Ping Lin

    Citation: Clinical and Translational Medicine 2015 4:38

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    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:6

  3. Content type: Review

    High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architectur...

    Authors: Sunghee Oh, Hong Ji, Drew Barzman, Ping-I Lin and John Hutton

    Citation: Clinical and Translational Medicine 2015 4:37

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  4. Content type: Perspective

    Relationships between industry and university-based researchers have been commonplace for decades and have received notable attention concerning the conflicts of interest these relationships may harbor. While ...

    Authors: Eric M. Meslin, Joshua B. Rager, Peter H. Schwartz, Kimberly A. Quaid, Margaret M. Gaffney, Jon Duke and William M. Tierney

    Citation: Clinical and Translational Medicine 2015 4:36

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    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:4

  5. Content type: Review

    Lung cancer is the most common cancer type worldwide and the leading cause of cancer related deaths in the United States. The majority of newly diagnosed patients present with late stage metastatic lung cancer...

    Authors: Miranda B. Carper and Pier Paolo Claudio

    Citation: Clinical and Translational Medicine 2015 4:33

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  6. Content type: Short report

    The development of commercially available panels for human blood plasma screening via selected reaction monitoring (SRM) offers reliable, cost-efficient and highly-standardized discovery and validation of prot...

    Authors: Olga I. Kiseleva, Yulia A. Romashova, Natalia E. Moskaleva, Natalia A. Petushkova, Nadezhda B. Teryaeva, Artem Yu. Belyaev and Andrey V. Lisitsa

    Citation: Clinical and Translational Medicine 2015 4:32

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  7. Content type: Research

    To assess the effect of respiratory training (RT) on lung function, activity tolerance and acute exacerbation frequency with chronic obstructive pulmonary disease (COPD).

    Authors: Fang Xi, Zheng Wang, Yong Qi, Richard Brightwell, Peter Roberts, Angus Stewart, Moira Sim and Wei Wang

    Citation: Clinical and Translational Medicine 2015 4:31

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  8. Content type: Editorial

    Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease. This has led to an ...

    Authors: Mingyan He, Jinglin Xia, Mohamed Shehab and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2015 4:28

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  9. Content type: Research

    In the postgenomic era, it has become evident that analysis of genetic and protein expression changes alone is not sufficient to understand most disease processes in e.g. cardiovascular and cancer disease. Bio...

    Authors: Johan Malm, Henrik Lindberg, David Erlinge, Roger Appelqvist, Maria Yakovleva, Charlotte Welinder, Erik Steinfelder, Thomas E Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2015 4:27

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  10. Content type: Research

    Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one poss...

    Authors: Haiyun Wang, Xiaoqi Zheng, Teng Fei, Jinzeng Wang, Xujuan Li, Yin Liu and Fan Zhang

    Citation: Clinical and Translational Medicine 2015 4:25

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  11. Content type: Research article

    In the new pathologic classification of lung adenocarcinoma proposed by IASLC/ATS/ERS in 2011, lepidic type adenocarcinomas are constituted by three subtypes; adenocarcinoma in situ (AIS), minimally invasive a...

    Authors: Yasufumi Kato, Haruhiko Nakamura, Hiromasa Tojo, Masaharu Nomura, Toshitaka Nagao, Takeshi Kawamura, Tatsuhiko Kodama, Tatsuo Ohira, Norihiko Ikeda, Thomas Fehniger, György Marko-Varga, Toshihide Nishimura and Harubumi Kato

    Citation: Clinical and Translational Medicine 2015 4:24

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  12. Content type: Review

    Despite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic fac...

    Authors: Wei Chen and Lorraine B Ware

    Citation: Clinical and Translational Medicine 2015 4:23

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  13. Content type: Research article

    Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and infl...

    Authors: Li Ma, Ciara M. Shaver, Brandon S. Grove, Daphne B. Mitchell, Nancy E. Wickersham, Robert H. Carnahan, Tracy L. Cooper, Brittany E. Brake, Lorraine B. Ware and Julie A. Bastarache

    Citation: Clinical and Translational Medicine 2015 4:22

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  14. Content type: Research

    As the high throughput sequencing efforts generate more biological information, scientists from different disciplines are interpreting the polymorphisms that make us unique. In addition, there is an increasing...

    Authors: Timo Tiirikka and Jukka S Moilanen

    Citation: Clinical and Translational Medicine 2015 4:20

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  15. Content type: Research article

    In spite of the implementations of several strategies, tuberculosis (TB) is overwhelmingly a serious global public health problem causing millions of infections and deaths every year. This is mainly due to the...

    Authors: Tilahun Melak and Sunita Gakkhar

    Citation: Clinical and Translational Medicine 2015 4:19

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  16. Content type: Commentary

    The activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation and survival, is orchestrated by protein kinases via phosphorylation. A critical i...

    Authors: Elena López Villar, Luis Madero, Juan A López-Pascual and William C Cho

    Citation: Clinical and Translational Medicine 2015 4:18

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  17. Content type: Research

    To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in a Cameroonian population.

    Authors: Dieudonne Nanfa, Eugene Sobngwi, Barbara Atogho-Tiedeu, Jean Jacques N Noubiap, Olivier Sontsa Donfack, Edith Pascale Mato Mofo, Magellan Guewo-Fokeng, Aurelie Nguimmo Metsadjio, Elvis Ndonwi Ngwa, Priscille Pokam Fosso, Eric Djahmeni, Rosine Djokam-Dadjeu, Marie-Solange Evehe, Folefac Aminkeng, Wilfred F Mbacham and Jean Claude Mbanya

    Citation: Clinical and Translational Medicine 2015 4:17

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  18. Content type: Research

    Fine needle aspiration (FNA) biopsy plays a critical role in the diagnosis and staging of lung primary and metastatic lung carcinoma. Accurate subclassification of adenocarcinoma (ADC) and/or squamous cell car...

    Authors: Grzegorz T Gurda, Lei Zhang, Yuting Wang, Li Chen, Susan Geddes, William C Cho, Frederic Askin, Edward Gabrielson and Qing Kay Li

    Citation: Clinical and Translational Medicine 2015 4:16

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  19. Content type: Perspective

    Graduate medical education has traditionally focused on training future physicians to be outstanding clinicians with basic and clinical science research skills. This focus has resulted in substantial knowledge...

    Authors: Patrick D Loftus, Craig T Elder, Troy D’Ambrosio and John T Langell

    Citation: Clinical and Translational Medicine 2015 4:15

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  20. Content type: Review

    Epithelial mesenchymal transition (EMT) is a physiological process necessary to normal embryologic development. However in genesis of pathological situations, this transition can be perverted and signaling pat...

    Authors: Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri and Michel Rigaud

    Citation: Clinical and Translational Medicine 2015 4:14

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  21. Content type: Research

    Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited...

    Authors: William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston and Johann E Gudjonsson

    Citation: Clinical and Translational Medicine 2015 4:13

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  22. Content type: Review

    Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implic...

    Authors: Ranjit Ganguly, Ahmed Mohyeldin, Jordyn Thiel, Harley I Kornblum, Monique Beullens and Ichiro Nakano

    Citation: Clinical and Translational Medicine 2015 4:11

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  23. Content type: Research

    Low grade gliomas are the most common brain tumor in children. Tandem duplication involving the KIAA1549 and the BRAF kinase genes results in a gene fusion that has been recently characterized in a subset of low ...

    Authors: Hala Taha, Maha Yehia, Madeha Mahmoud, Mohamed El-Beltagy, Myret Ghabriel and Shahenda El-Naggar

    Citation: Clinical and Translational Medicine 2015 4:10

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  24. Content type: Research

    Catheter-related bloodstream infections (CRBSIs) and catheter-related thrombosis (CRT) are common complications of central venous catheters (CVC), which are used to monitor patient health and deliver medicatio...

    Authors: Rhea M May, Chelsea M Magin, Ethan E Mann, Michael C Drinker, John C Fraser, Christopher A Siedlecki, Anthony B Brennan and Shravanthi T Reddy

    Citation: Clinical and Translational Medicine 2015 4:9

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  25. Content type: Review

    Tissue macrophages play important roles in maintaining homeostasis in most organs of the body including the brain where microglia represent the resident phagocytic cells of this compartment. The possibility of...

    Authors: Amanda Brown

    Citation: Clinical and Translational Medicine 2015 4:7

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  26. Content type: Review

    EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these pr...

    Authors: Sarah Heerboth, Genevieve Housman, Meghan Leary, Mckenna Longacre, Shannon Byler, Karolina Lapinska, Amber Willbanks and Sibaji Sarkar

    Citation: Clinical and Translational Medicine 2015 4:6

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  27. Content type: Review

    Monocytes are primitive hematopoietic cells that primarily arise from the bone marrow, circulate in the peripheral blood and give rise to differentiated macrophages. Over the past two decades, considerable att...

    Authors: Brian K Stansfield and David A Ingram

    Citation: Clinical and Translational Medicine 2015 4:5

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  28. Content type: Research

    Fatigue is common in cancer patients receiving adjuvant chemotherapy. To further understand the mechanism of fatigue and search for potential biomarkers, we conducted this prospective study. Methods

    Authors: Felipe M Cruz, Bruna A Munhoz, Beatriz CA Alves, Flavia S Gehrke, Fernando LA Fonseca, Renata K Kuniyoshi, Daniel Cubero, Luke J Peppone and Auro del Giglio

    Citation: Clinical and Translational Medicine 2015 4:4

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  29. Content type: Review

    Childhood immunisation is one of the greatest public health successes of the last century. Vaccines contain an active component (the antigen) which induces the immune response. They may also contain additional...

    Authors: Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Giuseppe Crisafulli, Liotti Lucia, Diego Peroni, Francesca Saretta, Mario Vernich, Carlotta Povesi Dascola and Carlo Caffarelli

    Citation: Clinical and Translational Medicine 2015 4:3

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  30. Content type: Review

    The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality. The molecu...

    Authors: Peter J Wermuth and Sergio A Jimenez

    Citation: Clinical and Translational Medicine 2015 4:2

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  31. Content type: Research

    Intestinal fibrosis and subsequent stricture formation represent frequent complications of Crohn’s disease (CD). In many organs, fibrosis develops as a result of epithelial to mesenchymal transition (EMT). Rec...

    Authors: Michael Scharl, Nicole Huber, Silvia Lang, Alois Fürst, Ekkehard Jehle and Gerhard Rogler

    Citation: Clinical and Translational Medicine 2015 4:1

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  32. Content type: Review

    Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT ...

    Authors: Christian A Graves, Fadi F Abboodi, Swati Tomar, James Wells and Lucia Pirisi

    Citation: Clinical and Translational Medicine 2014 3:39

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  33. Content type: Review

    Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macro...

    Authors: Hannah C Bygd, Kiva D Forsmark and Kaitlin M Bratlie

    Citation: Clinical and Translational Medicine 2014 3:62

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  34. Content type: Perspective

    The Tokyo Medical University Hospital in Japan and the Lund University hospital in Sweden have recently initiated a research program with the objective to impact on patient treatment by clinical disease stage ...

    Authors: Toshihide Nishimura, Takeshi Kawamura, Yutaka Sugihara, Yasuhiko Bando, Shigeru Sakamoto, Masaharu Nomura, Norihiko Ikeda, Tatsuo Ohira, Junichiro Fujimoto, Hiromasa Tojo, Takao Hamakubo, Tatsuhiko Kodama, Roland Andersson, Thomas E Fehniger, Harubumi Kato and György Marko-Varga

    Citation: Clinical and Translational Medicine 2014 3:61

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  35. Content type: Research

    We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-...

    Authors: Yuchen Sun, Tomomi Furihata, Seiya Ishii, Miki Nagai, Manami Harada, Osamu Shimozato, Takehiko Kamijo, Shinichiro Motohashi, Ichiro Yoshino, Atsuko Kamiichi, Kaoru Kobayashi and Kan Chiba

    Citation: Clinical and Translational Medicine 2014 3:37

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  36. Content type: Research

    Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases...

    Authors: Martin Letzkus, Evert Luesink, Sandrine Starck-Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson and Frank Staedtler

    Citation: Clinical and Translational Medicine 2014 3:36

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  37. Content type: Editorial

    Unfortunately, the research effort directed into chronic obstructive pulmonary disease (COPD) has been disproportionately weak compared to its social importance, and indeed it is the least researched of all co...

    Authors: Sukhwinder Singh Sohal, Malik Quasir Mahmood and Eugene Haydn Walters

    Citation: Clinical and Translational Medicine 2014 3:33

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  38. Content type: Research

    Urine markers have been studied extensively but there is a lack of blood prognostic markers in bladder cancer. MMP-7 is produced by stromal cells and by tumor cells and is overexpressed in a variety of epithel...

    Authors: Mounira El Demery, Gaiané Demirdjian-Sarkissian, Simon Thezenas, William Jacot, Yassine Laghzali, Bruno Darbouret, Stéphane Culine, Xavier Rebillard and Pierre-Jean Lamy

    Citation: Clinical and Translational Medicine 2014 3:31

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  39. Content type: Review

    Acute Respiratory Distress Syndrome (ARDS) is a devastating cause of hypoxic respiratory failure, which continues to have high mortality. It is expected that a comprehensive systems- level approach will identi...

    Authors: Maneesh Bhargava, LeeAnn Higgins, Christine H Wendt and David H Ingbar

    Citation: Clinical and Translational Medicine 2014 3:34

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  40. Content type: Review

    In the past decade, the traditional view of cancers as a homogeneous collection of malignant cells is being replaced by a model of ever increasing complexity suggesting that cancers are complex tissues compose...

    Authors: Yongyou Zhu, Ming Luo, Michael Brooks, Shawn G Clouthier and Max S Wicha

    Citation: Clinical and Translational Medicine 2014 3:32

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