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  1. Content type: Research

    As the high throughput sequencing efforts generate more biological information, scientists from different disciplines are interpreting the polymorphisms that make us unique. In addition, there is an increasing...

    Authors: Timo Tiirikka and Jukka S Moilanen

    Citation: Clinical and Translational Medicine 2015 4:20

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  2. Content type: Research article

    In spite of the implementations of several strategies, tuberculosis (TB) is overwhelmingly a serious global public health problem causing millions of infections and deaths every year. This is mainly due to the...

    Authors: Tilahun Melak and Sunita Gakkhar

    Citation: Clinical and Translational Medicine 2015 4:19

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  3. Content type: Commentary

    The activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation and survival, is orchestrated by protein kinases via phosphorylation. A critical i...

    Authors: Elena López Villar, Luis Madero, Juan A López-Pascual and William C Cho

    Citation: Clinical and Translational Medicine 2015 4:18

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  4. Content type: Research

    To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in a Cameroonian population.

    Authors: Dieudonne Nanfa, Eugene Sobngwi, Barbara Atogho-Tiedeu, Jean Jacques N Noubiap, Olivier Sontsa Donfack, Edith Pascale Mato Mofo, Magellan Guewo-Fokeng, Aurelie Nguimmo Metsadjio, Elvis Ndonwi Ngwa, Priscille Pokam Fosso, Eric Djahmeni, Rosine Djokam-Dadjeu, Marie-Solange Evehe, Folefac Aminkeng, Wilfred F Mbacham and Jean Claude Mbanya

    Citation: Clinical and Translational Medicine 2015 4:17

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  5. Content type: Research

    Fine needle aspiration (FNA) biopsy plays a critical role in the diagnosis and staging of lung primary and metastatic lung carcinoma. Accurate subclassification of adenocarcinoma (ADC) and/or squamous cell car...

    Authors: Grzegorz T Gurda, Lei Zhang, Yuting Wang, Li Chen, Susan Geddes, William C Cho, Frederic Askin, Edward Gabrielson and Qing Kay Li

    Citation: Clinical and Translational Medicine 2015 4:16

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  6. Content type: Perspective

    Graduate medical education has traditionally focused on training future physicians to be outstanding clinicians with basic and clinical science research skills. This focus has resulted in substantial knowledge...

    Authors: Patrick D Loftus, Craig T Elder, Troy D’Ambrosio and John T Langell

    Citation: Clinical and Translational Medicine 2015 4:15

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  7. Content type: Review

    Epithelial mesenchymal transition (EMT) is a physiological process necessary to normal embryologic development. However in genesis of pathological situations, this transition can be perverted and signaling pat...

    Authors: Guislaine Barriere, Pietro Fici, Giulia Gallerani, Francesco Fabbri and Michel Rigaud

    Citation: Clinical and Translational Medicine 2015 4:14

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  8. Content type: Research

    Psoriasis is a cytokine-mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited...

    Authors: William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston and Johann E Gudjonsson

    Citation: Clinical and Translational Medicine 2015 4:13

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  9. Content type: Review

    Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implic...

    Authors: Ranjit Ganguly, Ahmed Mohyeldin, Jordyn Thiel, Harley I Kornblum, Monique Beullens and Ichiro Nakano

    Citation: Clinical and Translational Medicine 2015 4:11

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  10. Content type: Research

    Low grade gliomas are the most common brain tumor in children. Tandem duplication involving the KIAA1549 and the BRAF kinase genes results in a gene fusion that has been recently characterized in a subset of low ...

    Authors: Hala Taha, Maha Yehia, Madeha Mahmoud, Mohamed El-Beltagy, Myret Ghabriel and Shahenda El-Naggar

    Citation: Clinical and Translational Medicine 2015 4:10

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  11. Content type: Review

    EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these pr...

    Authors: Sarah Heerboth, Genevieve Housman, Meghan Leary, Mckenna Longacre, Shannon Byler, Karolina Lapinska, Amber Willbanks and Sibaji Sarkar

    Citation: Clinical and Translational Medicine 2015 4:6

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  12. Content type: Review

    Tissue macrophages play important roles in maintaining homeostasis in most organs of the body including the brain where microglia represent the resident phagocytic cells of this compartment. The possibility of...

    Authors: Amanda Brown

    Citation: Clinical and Translational Medicine 2015 4:7

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  13. Content type: Research

    Catheter-related bloodstream infections (CRBSIs) and catheter-related thrombosis (CRT) are common complications of central venous catheters (CVC), which are used to monitor patient health and deliver medicatio...

    Authors: Rhea M May, Chelsea M Magin, Ethan E Mann, Michael C Drinker, John C Fraser, Christopher A Siedlecki, Anthony B Brennan and Shravanthi T Reddy

    Citation: Clinical and Translational Medicine 2015 4:9

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  14. Content type: Review

    Childhood immunisation is one of the greatest public health successes of the last century. Vaccines contain an active component (the antigen) which induces the immune response. They may also contain additional...

    Authors: Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Giuseppe Crisafulli, Liotti Lucia, Diego Peroni, Francesca Saretta, Mario Vernich, Carlotta Povesi Dascola and Carlo Caffarelli

    Citation: Clinical and Translational Medicine 2015 4:3

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  15. Content type: Review

    Monocytes are primitive hematopoietic cells that primarily arise from the bone marrow, circulate in the peripheral blood and give rise to differentiated macrophages. Over the past two decades, considerable att...

    Authors: Brian K Stansfield and David A Ingram

    Citation: Clinical and Translational Medicine 2015 4:5

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  16. Content type: Research

    Fatigue is common in cancer patients receiving adjuvant chemotherapy. To further understand the mechanism of fatigue and search for potential biomarkers, we conducted this prospective study. Methods

    Authors: Felipe M Cruz, Bruna A Munhoz, Beatriz CA Alves, Flavia S Gehrke, Fernando LA Fonseca, Renata K Kuniyoshi, Daniel Cubero, Luke J Peppone and Auro del Giglio

    Citation: Clinical and Translational Medicine 2015 4:4

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  17. Content type: Review

    The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality. The molecu...

    Authors: Peter J Wermuth and Sergio A Jimenez

    Citation: Clinical and Translational Medicine 2015 4:2

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  18. Content type: Research

    Intestinal fibrosis and subsequent stricture formation represent frequent complications of Crohn’s disease (CD). In many organs, fibrosis develops as a result of epithelial to mesenchymal transition (EMT). Rec...

    Authors: Michael Scharl, Nicole Huber, Silvia Lang, Alois Fürst, Ekkehard Jehle and Gerhard Rogler

    Citation: Clinical and Translational Medicine 2015 4:1

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  19. Content type: Review

    Positive markers of epithelial-mesenchymal transition (EMT) in head and neck cancers complicate clinical management and are associated with reduced survival. We discuss recent translational discoveries in EMT ...

    Authors: Christian A Graves, Fadi F Abboodi, Swati Tomar, James Wells and Lucia Pirisi

    Citation: Clinical and Translational Medicine 2014 3:39

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  20. Content type: Review

    Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macro...

    Authors: Hannah C Bygd, Kiva D Forsmark and Kaitlin M Bratlie

    Citation: Clinical and Translational Medicine 2014 3:62

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  21. Content type: Perspective

    The Tokyo Medical University Hospital in Japan and the Lund University hospital in Sweden have recently initiated a research program with the objective to impact on patient treatment by clinical disease stage ...

    Authors: Toshihide Nishimura, Takeshi Kawamura, Yutaka Sugihara, Yasuhiko Bando, Shigeru Sakamoto, Masaharu Nomura, Norihiko Ikeda, Tatsuo Ohira, Junichiro Fujimoto, Hiromasa Tojo, Takao Hamakubo, Tatsuhiko Kodama, Roland Andersson, Thomas E Fehniger, Harubumi Kato and György Marko-Varga

    Citation: Clinical and Translational Medicine 2014 3:61

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  22. Content type: Research

    We have previously identified the cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) mRNA in several human colon and lung cancer tissues. Ct-OATP1B3 is a variant of the liver-type OATP1B3 (Lt-...

    Authors: Yuchen Sun, Tomomi Furihata, Seiya Ishii, Miki Nagai, Manami Harada, Osamu Shimozato, Takehiko Kamijo, Shinichiro Motohashi, Ichiro Yoshino, Atsuko Kamiichi, Kaoru Kobayashi and Kan Chiba

    Citation: Clinical and Translational Medicine 2014 3:37

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  23. Content type: Research

    Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns. Many diseases...

    Authors: Martin Letzkus, Evert Luesink, Sandrine Starck-Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson and Frank Staedtler

    Citation: Clinical and Translational Medicine 2014 3:36

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  24. Content type: Editorial

    Unfortunately, the research effort directed into chronic obstructive pulmonary disease (COPD) has been disproportionately weak compared to its social importance, and indeed it is the least researched of all co...

    Authors: Sukhwinder Singh Sohal, Malik Quasir Mahmood and Eugene Haydn Walters

    Citation: Clinical and Translational Medicine 2014 3:33

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  25. Content type: Research

    Urine markers have been studied extensively but there is a lack of blood prognostic markers in bladder cancer. MMP-7 is produced by stromal cells and by tumor cells and is overexpressed in a variety of epithel...

    Authors: Mounira El Demery, Gaiané Demirdjian-Sarkissian, Simon Thezenas, William Jacot, Yassine Laghzali, Bruno Darbouret, Stéphane Culine, Xavier Rebillard and Pierre-Jean Lamy

    Citation: Clinical and Translational Medicine 2014 3:31

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  26. Content type: Review

    Acute Respiratory Distress Syndrome (ARDS) is a devastating cause of hypoxic respiratory failure, which continues to have high mortality. It is expected that a comprehensive systems- level approach will identi...

    Authors: Maneesh Bhargava, LeeAnn Higgins, Christine H Wendt and David H Ingbar

    Citation: Clinical and Translational Medicine 2014 3:34

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  27. Content type: Review

    In the past decade, the traditional view of cancers as a homogeneous collection of malignant cells is being replaced by a model of ever increasing complexity suggesting that cancers are complex tissues compose...

    Authors: Yongyou Zhu, Ming Luo, Michael Brooks, Shawn G Clouthier and Max S Wicha

    Citation: Clinical and Translational Medicine 2014 3:32

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  28. Content type: Research

    Snail, a transcriptional factor and repressor of E-cadherin is well known for its role in cellular invasion. It can regulate epithelial to mesenchymal transition (EMT) during embryonic development and in epith...

    Authors: Samar Abdulkhalek, Olivia D Geen, Lacey Brodhagen, Fiona Haxho, Farah Alghamdi, Stephanie Allison, Duncan J Simmons, Leah K O'Shea, Ronald J Neufeld and Myron R Szewczuk

    Citation: Clinical and Translational Medicine 2014 3:28

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  29. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by mucus hypersecretion that contributes to disease related morbidity and is associated with increased mortality. The Lung Flute® is a new respirat...

    Authors: Sanjay Sethi, Jingjing Yin and Pamela K Anderson

    Citation: Clinical and Translational Medicine 2014 3:29

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  30. Content type: Review

    Control of cell number and organ size is critical for appropriate development and tissue homeostasis. Studies in both Drosophila and mammals have established the Hippo signaling pathway as an important modulator ...

    Authors: Dominic P Del Re

    Citation: Clinical and Translational Medicine 2014 3:27

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    The Erratum to this article has been published in Clinical and Translational Medicine 2015 4:12

  31. Content type: Review

    The management of Ventilator Associated Pneumonia (VAP) presents many difficulties because of the heterogeneity of the disease; the way the immunocompromised host and the aggressive ICU environment interact is...

    Authors: Ornella Piazza and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2014 3:26

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  32. Content type: Review

    The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used ...

    Authors: Alexander Aleynik, Kevin M Gernavage, Yasmine SH Mourad, Lauren S Sherman, Katherine Liu, Yuriy A Gubenko and Pranela Rameshwar

    Citation: Clinical and Translational Medicine 2014 3:24

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  33. Content type: Review

    Understanding the molecular nature of human cancer is essential to the development of effective and personalized therapies. Several different molecular signal transduction pathways drive tumorigenesis when der...

    Authors: Daniel A Barron and Jacob D Kagey

    Citation: Clinical and Translational Medicine 2014 3:25

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  34. Content type: Research

    Therapies based on mesenchymal stem cells (MSC) have been shown to have potential benefit in several clinical studies. We have shown that, using a medium-based approach, MSC can be induced to secrete elevated ...

    Authors: Yael Gothelf, Natalie Abramov, Adrian Harel and Daniel Offen

    Citation: Clinical and Translational Medicine 2014 3:21

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  35. Content type: Review

    The Hippo tumour suppressor pathway co-ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a conserved core Hippo signalling module receives signal ...

    Authors: Marta Gomez, Valenti Gomez and Alexander Hergovich

    Citation: Clinical and Translational Medicine 2014 3:22

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  36. Content type: Perspective

    The transfer of new scientific discoveries into healthcare interventions requires that basic and clinical researchers work together with health care providers to generate team science. These innovative models ...

    Authors: Estela S Estape, Mary Helen Mays, Rosanne Harrigan and Robert Mayberry

    Citation: Clinical and Translational Medicine 2014 3:20

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  37. Content type: Commentary

    Allostery is involved in the dynamic regulation of biological functions in proteins. Advances in allostery research have recently drawn great interest and brought allostery closer to the clinic. The present co...

    Authors: Peixin Huang and Elena López Villar

    Citation: Clinical and Translational Medicine 2014 3:18

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  38. Content type: Review

    The concept of epithelial-mesenchymal transition (EMT), a process where cells change their epithelial towards a mesenchymal phenotype, has gained overwhelming attention especially in the cancer research commun...

    Authors: Konrad Steinestel, Stefan Eder, Andres Jan Schrader and Julie Steinestel

    Citation: Clinical and Translational Medicine 2014 3:17

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  39. Content type: Review

    In 2010, Multilineage Differentiating Stress Enduring (Muse) cells were introduced to the scientific community, offering potential resolution to the issue of teratoma formation that plagues both embryonic stem...

    Authors: Ariel A Simerman, Daniel A Dumesic and Gregorio D Chazenbalk

    Citation: Clinical and Translational Medicine 2014 3:12

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