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  1. Content type: Review

    Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional ch...

    Authors: Gabriele D’Errico, Heather L. Machado and Bruno Sainz Jr.

    Citation: Clinical and Translational Medicine 2017 6:3

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  2. Content type: Perspective

    Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

    Authors: William B. Miller Jr. and John S. Torday

    Citation: Clinical and Translational Medicine 2017 6:2

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  3. Content type: Research

    There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

    Authors: Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

    Citation: Clinical and Translational Medicine 2017 6:1

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  4. Content type: Research

    Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

    Authors: Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:44

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  5. Content type: Research

    The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be li...

    Authors: Geeta Shroff

    Citation: Clinical and Translational Medicine 2016 5:43

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    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:36

  6. Content type: Review

    The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

    Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Citation: Clinical and Translational Medicine 2016 5:41

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    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:35

  7. Content type: Research

    We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

    Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Citation: Clinical and Translational Medicine 2016 5:40

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    The Correction to this article has been published in Clinical and Translational Medicine 2019 8:5

  8. Content type: Research

    Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

    Authors: Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

    Citation: Clinical and Translational Medicine 2016 5:39

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  9. Content type: Research

    Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Authors: Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Citation: Clinical and Translational Medicine 2016 5:37

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  10. Content type: Research

    Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Authors: Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Citation: Clinical and Translational Medicine 2016 5:36

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  11. Content type: Meeting abstracts

    A1 One health advances and successes in comparative medicine and translational research

    Authors: Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. Curiel, Hans Rindt, Carol Reinero, Carolyn J. Henry, Philip J. Bergman, Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha…

    Citation: Clinical and Translational Medicine 2016 5(Suppl 1):26

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    This article is part of a Supplement: Volume 5 Supplement 1

  12. Content type: Review

    Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their o...

    Authors: Whitney Faiella and Rony Atoui

    Citation: Clinical and Translational Medicine 2016 5:34

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  13. Content type: Research

    High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding of basic mechanisms of liver injury and repair. A metabolite profiling appro...

    Authors: M. Omair Sarfaraz, Robert P. Myers, Carla S. Coffin, Zu-Hua Gao, Abdel Aziz M. Shaheen, Pam M. Crotty, Ping Zhang, Hans J. Vogel and Aalim M. Weljie

    Citation: Clinical and Translational Medicine 2016 5:33

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  14. Content type: Research

    Immunotherapy of patients suffering from the human epidermal growth factor receptor 2 overexpressing (HER-2+) breast cancers with the anti-HER-2 antibodies results in increase of the patients’ overall survival. H...

    Authors: Marek Malecki, Chelsea Sabo, Afsoon Foorohar and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:32

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  15. Content type: Review

    The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a the...

    Authors: David Kitzenberg, Sean P. Colgan and Louise E. Glover

    Citation: Clinical and Translational Medicine 2016 5:31

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  16. Content type: Erratum

    Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:30

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    The original article was published in Clinical and Translational Medicine 2016 5:23

  17. Content type: Review

    Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known ...

    Authors: Christoph Herbel, Nikolaos Patsoukis, Kankana Bardhan, Pankaj Seth, Jessica D. Weaver and Vassiliki A. Boussiotis

    Citation: Clinical and Translational Medicine 2016 5:29

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  18. Content type: Review

    The major problem with cancer progression and anti-cancer therapy is the inherent ability of cancer cells to migrate and establish distant metastases. This ability to metastasize correlates with the presence i...

    Authors: Mariusz Z. Ratajczak, Malwina Suszynska and Magda Kucia

    Citation: Clinical and Translational Medicine 2016 5:28

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  19. Content type: Review

    Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ine...

    Authors: John Burke, Monte Hunter, Ravindra Kolhe, Carlos Isales, Mark Hamrick and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2016 5:27

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  20. Content type: Research

    Frailty has been defined in different ways and several diagnostic tools exist, but most of them are not applicable in routine primary care. Nonetheless, general practitioners (GPs) have a natural advantage in ...

    Authors: Michela Franchini, Stefania Pieroni, Loredana Fortunato, Tamara Knezevic, Michael Liebman and Sabrina Molinaro

    Citation: Clinical and Translational Medicine 2016 5:24

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  21. Content type: Perspective

    This is an update to our 2012 publication on clinical trial considerations on male contraception and collection of pregnancy information from female partner, after critical review of recent (draft) guidances r...

    Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:23

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    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:30

  22. Content type: Review

    Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progressi...

    Authors: Vicent Ribas, Carmen García-Ruiz and José C. Fernández-Checa

    Citation: Clinical and Translational Medicine 2016 5:22

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  23. Content type: Short report

    We proposed a method of using electrical stimulation for treatment of malignant melanoma through directly spray-printing liquid metal on skin as soft electrodes to deliver low intensity, intermediate frequency...

    Authors: Jun Li, Cangran Guo, Zhongshuai Wang, Kai Gao, Xudong Shi and Jing Liu

    Citation: Clinical and Translational Medicine 2016 5:21

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  24. Content type: Research

    Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Authors: Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Citation: Clinical and Translational Medicine 2016 5:18

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  25. Content type: Research

    Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition...

    Authors: Torry A. Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B. Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A. Komissarov, Mitsuo Ikebe and Steven Idell

    Citation: Clinical and Translational Medicine 2016 5:17

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  26. Content type: Review

    Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obst...

    Authors: James D. McCully, Sidney Levitsky, Pedro J. del Nido and Douglas B. Cowan

    Citation: Clinical and Translational Medicine 2016 5:16

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  27. Content type: Research

    The major therapeutic benefit of hydroxyurea, the only FDA-approved pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin (HbF) production that leads to significant red...

    Authors: Gift Dineo Pule, Shaheen Mowla, Nicolas Novitzky and Ambroise Wonkam

    Citation: Clinical and Translational Medicine 2016 5:15

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  28. Content type: Review

    One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Authors: Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Citation: Clinical and Translational Medicine 2016 5:13

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  29. Content type: Review

    Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these add...

    Authors: Ercole L. Cavalieri and Eleanor G. Rogan

    Citation: Clinical and Translational Medicine 2016 5:12

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  30. Content type: Research

    Tamoxifen is used in endocrine treatment of breast cancer to inhibit estrogen signaling. A set of stratified ER-positive and ER-negative tumor sections was subjected to manual deposition of tamoxifen solution ...

    Authors: Ákos Végvári, Alexander S. Shavkunov, Thomas E. Fehniger, Dorthe Grabau, Emma Niméus and György Marko-Varga

    Citation: Clinical and Translational Medicine 2016 5:10

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  31. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD...

    Authors: Mikael Truedsson, Johan Malm, K. Barbara Sahlin, May Bugge, Elisabet Wieslander, Magnus Dahlbäck, Roger Appelqvist, Thomas E. Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2016 5:9

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  32. Content type: Review

    Current debate in type 2 diabetes (T2DM) has focused on shortened leukocyte telomere length (LTL) as the result of a number of possible causes, including polymorphisms in mitochondrial uncoupling proteins (UCP...

    Authors: Yuling Zhou, Zhixin Ning, Yvonne Lee, Brett D. Hambly and Craig S. McLachlan

    Citation: Clinical and Translational Medicine 2016 5:8

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  33. Content type: Research

    Although China has a long history of using acupoints herbal patching (acupoints herbal patching means applying herbal patch on special acupoints to stimulate skin to form blisters, hyperemia, and even suppurat...

    Authors: Libing Zhu, Wei Zhang, Vivian Wong, Ziea Eric, Lixing Lao, Kwaiching Lo, Waichung Chan, To Yau and Lei Li

    Citation: Clinical and Translational Medicine 2016 5:5

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  34. Content type: Erratum

    Authors: Eric M. Meslin, Joshua B. Rager, Peter H. Schwartz, Kimberly A. Quaid, Margaret M. Gaffney, Jon Duke and William M. Tierney

    Citation: Clinical and Translational Medicine 2016 5:4

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    The original article was published in Clinical and Translational Medicine 2015 4:36

  35. Content type: Review

    Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in the 1920s, many scientists have tried to further the understanding of tumor bioenergetics. Particu...

    Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang

    Citation: Clinical and Translational Medicine 2016 5:3

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    The Correction to this article has been published in Clinical and Translational Medicine 2018 7:8

  36. Content type: Research

    Anesthesia-induced neurotoxicity research in the developing brain must rely upon an unimpeachable animal model and a standardized treatment approach. In this manner, identification of mechanisms of action may ...

    Authors: Emmett E. Whitaker, Bruno Bissonnette, Andrew D. Miller, Tanner L. Koppert, Joseph D. Tobias, Christopher R. Pierson and Fievos L. Christofi

    Citation: Clinical and Translational Medicine 2016 5:2

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