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  1. Lipidomics is the identification and quantitation of changes in the lipidome of a cell, tissue, organ or biofluid in health and disease using high resolution mass spectrometry. Lipidome of a particular organis...

    Authors: Arkasubhra Ghosh and Krishnatej Nishtala

    Citation: Clinical and Translational Medicine 2017 6:22

    Content type: Review

    Published on:

  2. Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network...

    Authors: Raquel Cuevas-Diaz Duran, Haichao Wei and Jia Qian Wu

    Citation: Clinical and Translational Medicine 2017 6:20

    Content type: Review

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  3. Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopathologies and a...

    Authors: Wenli Li and Juergen Pauluhn

    Citation: Clinical and Translational Medicine 2017 6:19

    Content type: Review

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  4. Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress...

    Authors: Chaolei Chen, Xiaomin Huang, Zhaojian Ying, Dengmin Wu, Yani Yu, Xiangdong Wang and Chengshui Chen

    Citation: Clinical and Translational Medicine 2017 6:18

    Content type: Review

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  5. Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to ...

    Authors: Shayan Moazeni, Martin Cadeiras, Eric H. Yang, Mario C. Deng and Kim-Lien Nguyen

    Citation: Clinical and Translational Medicine 2017 6:17

    Content type: Review

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  6. The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, sm...

    Authors: Osamu Tetsu and Frank McCormick

    Citation: Clinical and Translational Medicine 2017 6:16

    Content type: Review

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  7. Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-...

    Authors: Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth

    Citation: Clinical and Translational Medicine 2017 6:15

    Content type: Review

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  8. Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated re...

    Authors: Yves Lecarpentier, Victor Claes, Alexandre Vallée and Jean-Louis Hébert

    Citation: Clinical and Translational Medicine 2017 6:14

    Content type: Review

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  9. The ability of salamanders, such as newts, to regenerate damaged tissues has been studied for centuries. A prominent example of this regenerative power is the ability to re-grow entire amputated limbs. One imp...

    Authors: JungIn Um, Da-Woon Jung and Darren Reece Williams

    Citation: Clinical and Translational Medicine 2017 6:13

    Content type: Commentary

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  10. As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr...

    Authors: Bruce K. Rubin

    Citation: Clinical and Translational Medicine 2017 6:12

    Content type: Perspective

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  11. Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation.

    Authors: George E. Naoum, Zeng B. Zhu, Donald J. Buchsbaum, David T. Curiel and Waleed O. Arafat

    Citation: Clinical and Translational Medicine 2017 6:11

    Content type: Research

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  12. Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se...

    Authors: Jian Wang and Yuanlin Song

    Citation: Clinical and Translational Medicine 2017 6:10

    Content type: Review

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  13. Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip...

    Authors: Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake

    Citation: Clinical and Translational Medicine 2017 6:9

    Content type: Commentary

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  14. Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm...

    Authors: Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt

    Citation: Clinical and Translational Medicine 2017 6:6

    Content type: Commentary

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  15. The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...

    Authors: Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton

    Citation: Clinical and Translational Medicine 2017 6:5

    Content type: Research

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  16. Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional ch...

    Authors: Gabriele D’Errico, Heather L. Machado and Bruno Sainz Jr.

    Citation: Clinical and Translational Medicine 2017 6:3

    Content type: Review

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  17. Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

    Authors: William B. Miller Jr. and John S. Torday

    Citation: Clinical and Translational Medicine 2017 6:2

    Content type: Perspective

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  18. There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

    Authors: Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

    Citation: Clinical and Translational Medicine 2017 6:1

    Content type: Research

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  19. Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

    Authors: Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:44

    Content type: Research

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  20. The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be li...

    Authors: Geeta Shroff

    Citation: Clinical and Translational Medicine 2016 5:43

    Content type: Research

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    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:36

  21. The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

    Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Citation: Clinical and Translational Medicine 2016 5:41

    Content type: Review

    Published on:

    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:35

  22. We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

    Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Citation: Clinical and Translational Medicine 2016 5:40

    Content type: Research

    Published on:

    The Correction to this article has been published in Clinical and Translational Medicine 2019 8:5

  23. Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

    Authors: Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

    Citation: Clinical and Translational Medicine 2016 5:39

    Content type: Research

    Published on:

  24. Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Authors: Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Citation: Clinical and Translational Medicine 2016 5:37

    Content type: Research

    Published on:

  25. Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Authors: Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Citation: Clinical and Translational Medicine 2016 5:36

    Content type: Research

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  26. A1 One health advances and successes in comparative medicine and translational research

    Authors: Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. Curiel, Hans Rindt, Carol Reinero, Carolyn J. Henry, Philip J. Bergman, Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha…

    Citation: Clinical and Translational Medicine 2016 5(Suppl 1):26

    Content type: Meeting abstracts

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    This article is part of a Supplement: Volume 5 Supplement 1

  27. Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their o...

    Authors: Whitney Faiella and Rony Atoui

    Citation: Clinical and Translational Medicine 2016 5:34

    Content type: Review

    Published on:

  28. High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding of basic mechanisms of liver injury and repair. A metabolite profiling appro...

    Authors: M. Omair Sarfaraz, Robert P. Myers, Carla S. Coffin, Zu-Hua Gao, Abdel Aziz M. Shaheen, Pam M. Crotty, Ping Zhang, Hans J. Vogel and Aalim M. Weljie

    Citation: Clinical and Translational Medicine 2016 5:33

    Content type: Research

    Published on:

  29. Immunotherapy of patients suffering from the human epidermal growth factor receptor 2 overexpressing (HER-2+) breast cancers with the anti-HER-2 antibodies results in increase of the patients’ overall survival. H...

    Authors: Marek Malecki, Chelsea Sabo, Afsoon Foorohar and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:32

    Content type: Research

    Published on:

  30. The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a the...

    Authors: David Kitzenberg, Sean P. Colgan and Louise E. Glover

    Citation: Clinical and Translational Medicine 2016 5:31

    Content type: Review

    Published on:

  31. Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:30

    Content type: Erratum

    Published on:

    The original article was published in Clinical and Translational Medicine 2016 5:23

  32. Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known ...

    Authors: Christoph Herbel, Nikolaos Patsoukis, Kankana Bardhan, Pankaj Seth, Jessica D. Weaver and Vassiliki A. Boussiotis

    Citation: Clinical and Translational Medicine 2016 5:29

    Content type: Review

    Published on:

  33. The major problem with cancer progression and anti-cancer therapy is the inherent ability of cancer cells to migrate and establish distant metastases. This ability to metastasize correlates with the presence i...

    Authors: Mariusz Z. Ratajczak, Malwina Suszynska and Magda Kucia

    Citation: Clinical and Translational Medicine 2016 5:28

    Content type: Review

    Published on:

  34. Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ine...

    Authors: John Burke, Monte Hunter, Ravindra Kolhe, Carlos Isales, Mark Hamrick and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2016 5:27

    Content type: Review

    Published on:

  35. Frailty has been defined in different ways and several diagnostic tools exist, but most of them are not applicable in routine primary care. Nonetheless, general practitioners (GPs) have a natural advantage in ...

    Authors: Michela Franchini, Stefania Pieroni, Loredana Fortunato, Tamara Knezevic, Michael Liebman and Sabrina Molinaro

    Citation: Clinical and Translational Medicine 2016 5:24

    Content type: Research

    Published on:

  36. This is an update to our 2012 publication on clinical trial considerations on male contraception and collection of pregnancy information from female partner, after critical review of recent (draft) guidances r...

    Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:23

    Content type: Perspective

    Published on:

    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:30

  37. Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progressi...

    Authors: Vicent Ribas, Carmen García-Ruiz and José C. Fernández-Checa

    Citation: Clinical and Translational Medicine 2016 5:22

    Content type: Review

    Published on:

  38. We proposed a method of using electrical stimulation for treatment of malignant melanoma through directly spray-printing liquid metal on skin as soft electrodes to deliver low intensity, intermediate frequency...

    Authors: Jun Li, Cangran Guo, Zhongshuai Wang, Kai Gao, Xudong Shi and Jing Liu

    Citation: Clinical and Translational Medicine 2016 5:21

    Content type: Short report

    Published on:

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