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  1. The ability of salamanders, such as newts, to regenerate damaged tissues has been studied for centuries. A prominent example of this regenerative power is the ability to re-grow entire amputated limbs. One imp...

    Authors: JungIn Um, Da-Woon Jung and Darren Reece Williams

    Citation: Clinical and Translational Medicine 2017 6:13

    Content type: Commentary

    Published on:

  2. As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr...

    Authors: Bruce K. Rubin

    Citation: Clinical and Translational Medicine 2017 6:12

    Content type: Perspective

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  3. Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation.

    Authors: George E. Naoum, Zeng B. Zhu, Donald J. Buchsbaum, David T. Curiel and Waleed O. Arafat

    Citation: Clinical and Translational Medicine 2017 6:11

    Content type: Research

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  4. Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se...

    Authors: Jian Wang and Yuanlin Song

    Citation: Clinical and Translational Medicine 2017 6:10

    Content type: Review

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  5. Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip...

    Authors: Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake

    Citation: Clinical and Translational Medicine 2017 6:9

    Content type: Commentary

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  6. Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm...

    Authors: Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt

    Citation: Clinical and Translational Medicine 2017 6:6

    Content type: Commentary

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  7. The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...

    Authors: Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton

    Citation: Clinical and Translational Medicine 2017 6:5

    Content type: Research

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  8. Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional ch...

    Authors: Gabriele D’Errico, Heather L. Machado and Bruno Sainz Jr.

    Citation: Clinical and Translational Medicine 2017 6:3

    Content type: Review

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  9. Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

    Authors: William B. Miller Jr. and John S. Torday

    Citation: Clinical and Translational Medicine 2017 6:2

    Content type: Perspective

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  10. There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

    Authors: Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

    Citation: Clinical and Translational Medicine 2017 6:1

    Content type: Research

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  11. Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

    Authors: Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:44

    Content type: Research

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  12. The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be li...

    Authors: Geeta Shroff

    Citation: Clinical and Translational Medicine 2016 5:43

    Content type: Research

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    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:36

  13. The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

    Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Citation: Clinical and Translational Medicine 2016 5:41

    Content type: Review

    Published on:

    The Erratum to this article has been published in Clinical and Translational Medicine 2017 6:35

  14. We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

    Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Citation: Clinical and Translational Medicine 2016 5:40

    Content type: Research

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    The Correction to this article has been published in Clinical and Translational Medicine 2019 8:5

  15. Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

    Authors: Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

    Citation: Clinical and Translational Medicine 2016 5:39

    Content type: Research

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  16. Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

    Authors: Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy

    Citation: Clinical and Translational Medicine 2016 5:37

    Content type: Research

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  17. Lung remodeling and pulmonary fibrosis are serious, life-threatening conditions resulting from diseases such as chronic severe asthma and idiopathic pulmonary fibrosis (IPF). Preclinical evidence suggests that...

    Authors: Jos L. J. van der Velden, Ying Ye, James D. Nolin, Sidra M. Hoffman, David G. Chapman, Karolyn G. Lahue, Sarah Abdalla, Peng Chen, Yong Liu, Brydon Bennett, Nasreen Khalil, Donna Sutherland, William Smith, Gerald Horan, Mahmoud Assaf, Zebulun Horowitz…

    Citation: Clinical and Translational Medicine 2016 5:36

    Content type: Research

    Published on:

  18. A1 One health advances and successes in comparative medicine and translational research

    Authors: Cheryl Stroud, Igor Dmitriev, Elena Kashentseva, Jeffrey N. Bryan, David T. Curiel, Hans Rindt, Carol Reinero, Carolyn J. Henry, Philip J. Bergman, Nicola J. Mason, Josephine S. Gnanandarajah, Julie B. Engiles, Falon Gray, Danielle Laughlin, Anita Gaurnier-Hausser, Anu Wallecha…

    Citation: Clinical and Translational Medicine 2016 5(Suppl 1):26

    Content type: Meeting abstracts

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    This article is part of a Supplement: Volume 5 Supplement 1

  19. Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their o...

    Authors: Whitney Faiella and Rony Atoui

    Citation: Clinical and Translational Medicine 2016 5:34

    Content type: Review

    Published on:

  20. High-throughput technologies have the potential to identify non-invasive biomarkers of liver pathology and improve our understanding of basic mechanisms of liver injury and repair. A metabolite profiling appro...

    Authors: M. Omair Sarfaraz, Robert P. Myers, Carla S. Coffin, Zu-Hua Gao, Abdel Aziz M. Shaheen, Pam M. Crotty, Ping Zhang, Hans J. Vogel and Aalim M. Weljie

    Citation: Clinical and Translational Medicine 2016 5:33

    Content type: Research

    Published on:

  21. Immunotherapy of patients suffering from the human epidermal growth factor receptor 2 overexpressing (HER-2+) breast cancers with the anti-HER-2 antibodies results in increase of the patients’ overall survival. H...

    Authors: Marek Malecki, Chelsea Sabo, Afsoon Foorohar and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:32

    Content type: Research

    Published on:

  22. The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a the...

    Authors: David Kitzenberg, Sean P. Colgan and Louise E. Glover

    Citation: Clinical and Translational Medicine 2016 5:31

    Content type: Review

    Published on:

  23. Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:30

    Content type: Erratum

    Published on:

    The original article was published in Clinical and Translational Medicine 2016 5:23

  24. Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known ...

    Authors: Christoph Herbel, Nikolaos Patsoukis, Kankana Bardhan, Pankaj Seth, Jessica D. Weaver and Vassiliki A. Boussiotis

    Citation: Clinical and Translational Medicine 2016 5:29

    Content type: Review

    Published on:

  25. The major problem with cancer progression and anti-cancer therapy is the inherent ability of cancer cells to migrate and establish distant metastases. This ability to metastasize correlates with the presence i...

    Authors: Mariusz Z. Ratajczak, Malwina Suszynska and Magda Kucia

    Citation: Clinical and Translational Medicine 2016 5:28

    Content type: Review

    Published on:

  26. Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ine...

    Authors: John Burke, Monte Hunter, Ravindra Kolhe, Carlos Isales, Mark Hamrick and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2016 5:27

    Content type: Review

    Published on:

  27. Frailty has been defined in different ways and several diagnostic tools exist, but most of them are not applicable in routine primary care. Nonetheless, general practitioners (GPs) have a natural advantage in ...

    Authors: Michela Franchini, Stefania Pieroni, Loredana Fortunato, Tamara Knezevic, Michael Liebman and Sabrina Molinaro

    Citation: Clinical and Translational Medicine 2016 5:24

    Content type: Research

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  28. This is an update to our 2012 publication on clinical trial considerations on male contraception and collection of pregnancy information from female partner, after critical review of recent (draft) guidances r...

    Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:23

    Content type: Perspective

    Published on:

    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:30

  29. Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progressi...

    Authors: Vicent Ribas, Carmen García-Ruiz and José C. Fernández-Checa

    Citation: Clinical and Translational Medicine 2016 5:22

    Content type: Review

    Published on:

  30. We proposed a method of using electrical stimulation for treatment of malignant melanoma through directly spray-printing liquid metal on skin as soft electrodes to deliver low intensity, intermediate frequency...

    Authors: Jun Li, Cangran Guo, Zhongshuai Wang, Kai Gao, Xudong Shi and Jing Liu

    Citation: Clinical and Translational Medicine 2016 5:21

    Content type: Short report

    Published on:

  31. Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Authors: Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Citation: Clinical and Translational Medicine 2016 5:18

    Content type: Research

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  32. Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition...

    Authors: Torry A. Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B. Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A. Komissarov, Mitsuo Ikebe and Steven Idell

    Citation: Clinical and Translational Medicine 2016 5:17

    Content type: Research

    Published on:

  33. Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obst...

    Authors: James D. McCully, Sidney Levitsky, Pedro J. del Nido and Douglas B. Cowan

    Citation: Clinical and Translational Medicine 2016 5:16

    Content type: Review

    Published on:

  34. The major therapeutic benefit of hydroxyurea, the only FDA-approved pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin (HbF) production that leads to significant red...

    Authors: Gift Dineo Pule, Shaheen Mowla, Nicolas Novitzky and Ambroise Wonkam

    Citation: Clinical and Translational Medicine 2016 5:15

    Content type: Research

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  35. One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Authors: Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Citation: Clinical and Translational Medicine 2016 5:13

    Content type: Review

    Published on:

  36. Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these add...

    Authors: Ercole L. Cavalieri and Eleanor G. Rogan

    Citation: Clinical and Translational Medicine 2016 5:12

    Content type: Review

    Published on:

  37. Tamoxifen is used in endocrine treatment of breast cancer to inhibit estrogen signaling. A set of stratified ER-positive and ER-negative tumor sections was subjected to manual deposition of tamoxifen solution ...

    Authors: Ákos Végvári, Alexander S. Shavkunov, Thomas E. Fehniger, Dorthe Grabau, Emma Niméus and György Marko-Varga

    Citation: Clinical and Translational Medicine 2016 5:10

    Content type: Research

    Published on:

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