Articles

Proteomics in asthma: the clinicians were right after all, were not they?

Clinical disease phenotypes with underlying information of molecular and biological signatures for the same, is a prerequisite for improving medical care and developing more effective, stratified management st...

Authors: Anirban Sinha and Peter J. Sterk

Optimization of culture conditions for rapid clinical-scale expansion of human umbilical cord blood-derived mesenchymal stem cells

Mesenchymal stem cells (MSCs) have broad-spectrum therapeutic effects in various diseases, and thus have many clinical applications. However, it is difficult to produce sufficient numbers of MSCs for clinical ...

Authors: Wankyu Choi, Soon-Jae Kwon, Hye Jin Jin, Sang Young Jeong, Soo Jin Choi, Wonil Oh, Yoon Sun Yang, Hong Bae Jeon and Eun Su Jeon

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib

Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic ac...

Authors: Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs and Anton Wellstein

Extracellular vesicles: how they interact with endothelium, potentially contributing to metastatic cancer cell implants

Extracellular vesicles (EV) are blebs of cellular membranes, which entrap small portions of subjacent cytosol. They are released from a variety of cells, circulate in the blood for an unknown length of time an...

Authors: Murray M. Bern

Expression of Concern to: Evaluation of patients with multiple sclerosis using reverse nutech functional score and expanded disability status scale after human embryonic stem cell therapy

The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

Authors: Geeta Shroff

Expression of Concern to: Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation

The Editors-in-Chief of Clinical and Translational Medicine are issuing an editorial expression of concern to alert readers that concerns have been raised regarding the ethics of this study [1]. Appropriate edito...

Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

Differences in immune response to anesthetics used for day surgery versus hospitalization surgery for breast cancer patients

Surgery/anesthetic technique-stimulated immunosuppression may be associated with outcome for cancer patients. Here, the immune responses of patients undergoing day surgery versus hospitalization surgery for br...

Authors: Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Yuri Funaoka, Shoichiro Ohtani, Mitsuya Ito, Takayuki Kadoya and Morihito Okada

Profiling of cardio-metabolic risk factors and medication utilisation among Type II diabetes patients in Ghana: a prospective cohort study

Type II diabetes mellitus (T2DM) is complicated by multiple cardio-metabolic risk factors. Controlling these factors requires lifestyle modifications alongside utilisation of anti-diabetic medications. Differe...

Authors: Eric Adua, Peter Roberts, Samuel Asamoah Sakyi, Francis Agyemang Yeboah, Albert Dompreh, Kwasi Frimpong, Enoch Odame Anto and Wei Wang

The role of lipids in corneal diseases and dystrophies: a systematic review

Corneal diseases are an extensive cause of blindness worldwide and continue to persist as a challenging public health concern. Recently, various lipid-based therapies have been advocated for the modulation of ...

Authors: Tyler G. Rowsey and Dimitrios Karamichos

RETRACTED ARTICLE: Purified umbilical cord derived mesenchymal stem cell treatment in a case of systemic lupus erythematosus

Authors: Christopher D. Phillips, Pornpatcharin Wongsaisri, Thein Htut and Terry Grossman

The role of heterogeneity in asthma: a structure-to-function perspective

A number of methods have evolved through the years in probing the dysfunction that impacts mechanics and ventilation in asthma. What has been consistently found is the notion of heterogeneity that is not only ...

Authors: Justin K. Lui and Kenneth R. Lutchen

Styrene maleic acid encapsulated raloxifene micelles for management of inflammatory bowel disease

Inflammatory bowel disease (IBD) comprises a group of disorders that manifest through chronic inflammation of the colon and small intestine. Although the exact cause of IBD is still unclear, dysfunctional immu...

Authors: Khaled Greish, Safa Taha, Anfal Jasim, Sara Abd Elghany, Ameera Sultan, Ali AlKhateeb, Manal Othman, Fang Jun, Sebastien Taurin and Moiz Bakhiet

Lipidomics and anti-trypanosomatid chemotherapy

Trypanosomatids such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi belong to the order Kinetoplastida and are the source of many significant human and animal diseases. Current treatment is unsatisfactor...

Authors: Michael Biagiotti, Sedelia Dominguez, Nader Yamout and Rachel Zufferey

CXCL9-11 polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross-sectional study

CXCL9-11 polymorphisms are related to various infectious diseases, including hepatitis C virus (HCV) infection. In this study, we analyzed the association between CXCL9-11 polymorphism...

Authors: María Ángeles Jiménez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Luz Maria Medrano, Juan José Sánchez-Ruano, Amanda Fernández-Rodríguez, Tomas Artaza-Varasa, José Saura-Montalban, Sonia Vázquez-Morón, Pablo Ryan and Salvador Resino

Significance of long chain polyunsaturated fatty acids in human health

In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid me...

Authors: Rafael Zárate, Nabil el Jaber-Vazdekis, Noemi Tejera, José A. Pérez and Covadonga Rodríguez

Autophagy and inflammation

Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal degradation pathway. Recently, increasing evidences have...

Authors: Mengjia Qian, Xiaocong Fang and Xiangdong Wang

Systems and precision medicine approaches to diabetes heterogeneity: a Big Data perspective

Big Data, and in particular Electronic Health Records, provide the medical community with a great opportunity to analyze multiple pathological conditions at an unprecedented depth for many complex diseases, in...

Authors: Enrico Capobianco

Biofluid lipidome: a source for potential diagnostic biomarkers

Lipidomics is the identification and quantitation of changes in the lipidome of a cell, tissue, organ or biofluid in health and disease using high resolution mass spectrometry. Lipidome of a particular organis...

Authors: Arkasubhra Ghosh and Krishnatej Nishtala

IFNγ-producing CD4⁺ T lymphocytes: the double-edged swords in tuberculosis

IFNγ-producing CD4⁺ T cells (IFNγ⁺CD4⁺ T cells) are the key orchestrators of protective immunity against Mycobacterium tuberculosis (Mtb). Primarily, these cells act by enabling Mtb-infected macrophages to enforc...

Authors: Pawan Kumar

Single-cell RNA-sequencing of the brain

Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network...

Authors: Raquel Cuevas-Diaz Duran, Haichao Wei and Jia Qian Wu

Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine

Phosgene (carbonyl dichloride) gas is an indispensable chemical inter-mediate used in numerous industrial processes. There is no clear consensus as to its time- and inhaled-dose-dependent etiopathologies and a...

Authors: Wenli Li and Juergen Pauluhn

Can glypican-3 be a disease-specific biomarker?

Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress...

Authors: Chaolei Chen, Xiaomin Huang, Zhaojian Ying, Dengmin Wu, Yani Yu, Xiangdong Wang and Chengshui Chen

Anthracycline induced cardiotoxicity: biomarkers and “Omics” technology in the era of patient specific care

Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to ...

Authors: Shayan Moazeni, Martin Cadeiras, Eric H. Yang, Mario C. Deng and Kim-Lien Nguyen

ETS-targeted therapy: can it substitute for MEK inhibitors?

The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, sm...

Authors: Osamu Tetsu and Frank McCormick

Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis

Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-...

Authors: Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth

Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway

Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta-catenin pathway and peroxisome proliferator-activated re...

Authors: Yves Lecarpentier, Victor Claes, Alexandre Vallée and Jean-Louis Hébert

Lessons from the swamp: developing small molecules that confer salamander muscle cellularization in mammals

The ability of salamanders, such as newts, to regenerate damaged tissues has been studied for centuries. A prominent example of this regenerative power is the ability to re-grow entire amputated limbs. One imp...

Authors: JungIn Um, Da-Woon Jung and Darren Reece Williams

Translational research in pediatric pulmonary disease, 2017

As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr...

Authors: Bruce K. Rubin

Survivin a radiogenetic promoter for glioblastoma viral gene therapy independently from CArG motifs

Radiogenetic therapy is a novel approach in the treatment of cancer, which employs genetic modification to alter the sensitivity of tumor cells to the effect of applied radiation.

Authors: George E. Naoum, Zeng B. Zhu, Donald J. Buchsbaum, David T. Curiel and Waleed O. Arafat

Single cell sequencing: a distinct new field

Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se...

Authors: Jian Wang and Yuanlin Song

Integrating phosphoproteomics into the clinical management of prostate cancer

Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip...

Authors: Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake

Re: Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer


Authors: Michael McKay

Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer

Immune checkpoint blockade therapy by targeting the programmed death protein 1/programmed death ligand 1 (PD-L1) axis using antibodies has yielded promising clinical responses in patients with non-small cell l...

Authors: Xiaoming Liu and William C. Cho

Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?

Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm...

Authors: Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt

The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes

The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...

Authors: Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton

Contact allergy to aluminium induced by commonly used pediatric vaccines

Authors: E. Bergfors, B. Trollfors, A. Inerot and A. Gente Lidholm

A current perspective on cancer immune therapy: step-by-step approach to constructing the magic bullet

Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional ch...

Authors: Gabriele D’Errico, Heather L. Machado and Bruno Sainz Jr.

A systematic approach to cancer: evolution beyond selection

Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

Authors: William B. Miller Jr. and John S. Torday

MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)

There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

Authors: Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

Clinical protein science developments for patient monitoring in hospital central laboratories

Patient care relies heavily on standardized tests performed in hospital laboratories, typically including clinical chemistry, pathology and microbiology. With the introduction of personalized medicine tremendo...

Authors: Johan Malm and György Marko-Varga

Safety concerns and hidden agenda behind HPV vaccines: another generation of drug-dependent society?

Analyses of data and hidden agenda behind repeated failed outcomes of cancer research and therapy, status of American health, safety concerns for HPV vaccines and future research considerations are summarized ...

Authors: Mahin Khatami

Choices have consequences: the nexus between DNA repair pathways and genomic instability in cancer

The genome is under constant assault from a multitude of sources that can lead to the formation of DNA double-stand breaks (DSBs). DSBs are cytotoxic lesions, which if left unrepaired could lead to genomic ins...

Authors: Sonali Bhattacharjee and Saikat Nandi

Novel paradigm for immunotherapy of ovarian cancer by engaging prophylactic immunity against hepatitis B virus

Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

Authors: Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

Evaluation of patients with multiple sclerosis using reverse nutech functional score and expanded disability status scale after human embryonic stem cell therapy

The expanded disability status scale (EDSS) is a validated and reliable tool to assess the extent of disabilities in patients with multiple sclerosis (MS). However, the use of this tool has been found to be li...

Authors: Geeta Shroff

A braided cancer river connects tumor heterogeneity and precision medicine

With the ever-increasing complexity of tumor heterogeneity (TH) discovered through cancer genome sequencing, it is apparent that TH has become the biggest hurdle for precision cancer therapeutics. Through stud...

Authors: James J. Hsieh and Emily H. Cheng

Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation

The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

Authors: Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases

We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

Authors: Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

Serum levels of S100A6 are unaltered in patients with resectable cholangiocarcinoma

Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

Authors: Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

Adult pulmonary tuberculosis as a pathological manifestation of hyperactive antimycobacterial immune response

The intricate relationship between tuberculosis (TB) and immune system remains poorly understood. It is generally believed that weakening of the immune response against Mycobacterium tuberculosis leads to reactiv...

Authors: Pawan Kumar

Pharmacokinetics of oseltamivir in infants under the age of 1 year

Oseltamivir is the only antiviral treatment recommended for influenza in young children over the age of 1 year. There is scant data on oseltamivir pharmacokinetics (PK) in infants <1 year. We set out to perfor...

Authors: Rashmi Dixit, Slade Matthews, Gulam Khandaker, Karen Walker, Marino Festa and Robert Booy