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  1. Content type: Research

    Immunotherapy of patients suffering from the human epidermal growth factor receptor 2 overexpressing (HER-2+) breast cancers with the anti-HER-2 antibodies results in increase of the patients’ overall survival. H...

    Authors: Marek Malecki, Chelsea Sabo, Afsoon Foorohar and Xenia Tombokan

    Citation: Clinical and Translational Medicine 2016 5:32

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  2. Content type: Review

    Stem cell treatments are a desirable therapeutic option to regenerate myocardium and improve cardiac function after myocardial infarction. Several different types of cells have been explored, each with their o...

    Authors: Whitney Faiella and Rony Atoui

    Citation: Clinical and Translational Medicine 2016 5:34

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  3. Content type: Review

    The creatine/phosphocreatine pathway plays a conserved and central role in energy metabolism. Compartmentalization of specific creatine kinase enzymes permits buffering of local high energy phosphates in a the...

    Authors: David Kitzenberg, Sean P. Colgan and Louise E. Glover

    Citation: Clinical and Translational Medicine 2016 5:31

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  4. Content type: Erratum

    Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:30

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    The original article was published in Clinical and Translational Medicine 2016 5:23

  5. Content type: Review

    Conversion of normal cells to cancer is accompanied with changes in their metabolism. During this conversion, cell metabolism undergoes a shift from oxidative phosphorylation to aerobic glycolysis, also known ...

    Authors: Christoph Herbel, Nikolaos Patsoukis, Kankana Bardhan, Pankaj Seth, Jessica D. Weaver and Vassiliki A. Boussiotis

    Citation: Clinical and Translational Medicine 2016 5:29

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  6. Content type: Review

    The major problem with cancer progression and anti-cancer therapy is the inherent ability of cancer cells to migrate and establish distant metastases. This ability to metastasize correlates with the presence i...

    Authors: Mariusz Z. Ratajczak, Malwina Suszynska and Magda Kucia

    Citation: Clinical and Translational Medicine 2016 5:28

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  7. Content type: Review

    Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ine...

    Authors: John Burke, Monte Hunter, Ravindra Kolhe, Carlos Isales, Mark Hamrick and Sadanand Fulzele

    Citation: Clinical and Translational Medicine 2016 5:27

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  8. Content type: Research

    Frailty has been defined in different ways and several diagnostic tools exist, but most of them are not applicable in routine primary care. Nonetheless, general practitioners (GPs) have a natural advantage in ...

    Authors: Michela Franchini, Stefania Pieroni, Loredana Fortunato, Tamara Knezevic, Michael Liebman and Sabrina Molinaro

    Citation: Clinical and Translational Medicine 2016 5:24

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  9. Content type: Review

    Given the role of mitochondria in oxygen consumption, metabolism and cell death regulation, alterations in mitochondrial function or dysregulation of cell death pathways contribute to the genesis and progressi...

    Authors: Vicent Ribas, Carmen García-Ruiz and José C. Fernández-Checa

    Citation: Clinical and Translational Medicine 2016 5:22

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  10. Content type: Perspective

    This is an update to our 2012 publication on clinical trial considerations on male contraception and collection of pregnancy information from female partner, after critical review of recent (draft) guidances r...

    Authors: Maria Longauer Banholzer, Christoph Wandel, Paul Barrow, Marie Mannino, Georg Schmitt, Melanie Guérard, Lutz Müller, Gerard Greig, Kenjie Amemiya, Richard Peck, Thomas Singer and Lucette Doessegger

    Citation: Clinical and Translational Medicine 2016 5:23

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    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:30

  11. Content type: Short report

    We proposed a method of using electrical stimulation for treatment of malignant melanoma through directly spray-printing liquid metal on skin as soft electrodes to deliver low intensity, intermediate frequency...

    Authors: Jun Li, Cangran Guo, Zhongshuai Wang, Kai Gao, Xudong Shi and Jing Liu

    Citation: Clinical and Translational Medicine 2016 5:21

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  12. Content type: Research

    Chromosomal microarray offers superior sensitivity for identification of submicroscopic copy number variants (CNV) and it is advocated to be the first tier genetic testing for patients with autism spectrum dis...

    Authors: Wai-Kwan Siu, Ching-Wan Lam, Chloe Miu Mak, Elizabeth Tak-Kwong Lau, Mary Hoi-Yin Tang, Wing-Fai Tang, Rachel Sui-Man Poon-Mak, Chi-Chiu Lee, Se-Fong Hung, Patrick Wing-Leung Leung, Karen Ling Kwong, Eric Kin-Cheong Yau, Grace Sui-Fun Ng, Nai-Chung Fong and Kwok-Yin Chan

    Citation: Clinical and Translational Medicine 2016 5:18

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  13. Content type: Research

    Pleural infection affects about 65,000 patients annually in the US and UK. In this and other forms of pleural injury, mesothelial cells (PMCs) undergo a process called mesothelial (Meso) mesenchymal transition...

    Authors: Torry A. Tucker, Ann Jeffers, Jake Boren, Brandon Quaid, Shuzi Owens, Kathleen B. Koenig, Yoshikazu Tsukasaki, Galina Florova, Andrey A. Komissarov, Mitsuo Ikebe and Steven Idell

    Citation: Clinical and Translational Medicine 2016 5:17

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  14. Content type: Review

    Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obst...

    Authors: James D. McCully, Sidney Levitsky, Pedro J. del Nido and Douglas B. Cowan

    Citation: Clinical and Translational Medicine 2016 5:16

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  15. Content type: Research

    The major therapeutic benefit of hydroxyurea, the only FDA-approved pharmacologic treatment for sickle cell disease (SCD), is directly related to fetal hemoglobin (HbF) production that leads to significant red...

    Authors: Gift Dineo Pule, Shaheen Mowla, Nicolas Novitzky and Ambroise Wonkam

    Citation: Clinical and Translational Medicine 2016 5:15

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  16. Content type: Review

    One major objective for our evolving understanding in the treatment of cancers will be to address how a combination of diagnosis and treatment strategies can be used to integrate patient and tumor variables wi...

    Authors: Björn L. D. M. Brücher, Yan Li, Philipp Schnabel, Martin Daumer, Timothy J. Wallace, Rainer Kube, Bruno Zilberstein, Scott Steele, Jan L. A. Voskuil and Ijaz S. Jamall

    Citation: Clinical and Translational Medicine 2016 5:13

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  17. Content type: Review

    Estrogens can initiate cancer by reacting with DNA. Specific metabolites of endogenous estrogens, the catechol estrogen-3,4-quinones, react with DNA to form depurinating estrogen-DNA adducts. Loss of these add...

    Authors: Ercole L. Cavalieri and Eleanor G. Rogan

    Citation: Clinical and Translational Medicine 2016 5:12

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  18. Content type: Research

    Tamoxifen is used in endocrine treatment of breast cancer to inhibit estrogen signaling. A set of stratified ER-positive and ER-negative tumor sections was subjected to manual deposition of tamoxifen solution ...

    Authors: Ákos Végvári, Alexander S. Shavkunov, Thomas E. Fehniger, Dorthe Grabau, Emma Niméus and György Marko-Varga

    Citation: Clinical and Translational Medicine 2016 5:10

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  19. Content type: Review

    Current debate in type 2 diabetes (T2DM) has focused on shortened leukocyte telomere length (LTL) as the result of a number of possible causes, including polymorphisms in mitochondrial uncoupling proteins (UCP...

    Authors: Yuling Zhou, Zhixin Ning, Yvonne Lee, Brett D. Hambly and Craig S. McLachlan

    Citation: Clinical and Translational Medicine 2016 5:8

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  20. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is an irreversible disease, diagnosed predominantly in smokers. COPD is currently the third leading cause of death worldwide. Far more than 15 % of smokers get COPD...

    Authors: Mikael Truedsson, Johan Malm, K. Barbara Sahlin, May Bugge, Elisabet Wieslander, Magnus Dahlbäck, Roger Appelqvist, Thomas E. Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2016 5:9

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  21. Content type: Research

    Although China has a long history of using acupoints herbal patching (acupoints herbal patching means applying herbal patch on special acupoints to stimulate skin to form blisters, hyperemia, and even suppurat...

    Authors: Libing Zhu, Wei Zhang, Vivian Wong, Ziea Eric, Lixing Lao, Kwaiching Lo, Waichung Chan, To Yau and Lei Li

    Citation: Clinical and Translational Medicine 2016 5:5

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  22. Content type: Erratum

    Authors: Eric M. Meslin, Joshua B. Rager, Peter H. Schwartz, Kimberly A. Quaid, Margaret M. Gaffney, Jon Duke and William M. Tierney

    Citation: Clinical and Translational Medicine 2016 5:4

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    The original article was published in Clinical and Translational Medicine 2015 4:36

  23. Content type: Review

    Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in the 1920s, many scientists have tried to further the understanding of tumor bioenergetics. Particu...

    Authors: Md Maksudul Alam, Sneha Lal, Keely E. FitzGerald and Li Zhang

    Citation: Clinical and Translational Medicine 2016 5:3

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    The Correction to this article has been published in Clinical and Translational Medicine 2018 7:8

  24. Content type: Research

    Anesthesia-induced neurotoxicity research in the developing brain must rely upon an unimpeachable animal model and a standardized treatment approach. In this manner, identification of mechanisms of action may ...

    Authors: Emmett E. Whitaker, Bruno Bissonnette, Andrew D. Miller, Tanner L. Koppert, Joseph D. Tobias, Christopher R. Pierson and Fievos L. Christofi

    Citation: Clinical and Translational Medicine 2016 5:2

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  25. Content type: Research

    Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5 year survival rate of 20–30 %. Various factors have been implicated in the pathogenesis of ACC including dysregulation of the G2/M transition and...

    Authors: Kimberly J. Bussey, Aditi Bapat, Claire Linnehan, Melissa Wandoloski, Erica Dastrup, Erik Rogers, Paul Gonzales and Michael J. Demeure

    Citation: Clinical and Translational Medicine 2016 5:1

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  26. Content type: Review

    Application of tumor cell surface adhesion molecule EpCAM-dependent antibody capture, and intracellular cytokeratins (CKs)-dependent immunostaining strategies to detect disseminated or circulating tumor cells ...

    Authors: Peter Ping Lin

    Citation: Clinical and Translational Medicine 2015 4:38

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    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:6

  27. Content type: Perspective

    Relationships between industry and university-based researchers have been commonplace for decades and have received notable attention concerning the conflicts of interest these relationships may harbor. While ...

    Authors: Eric M. Meslin, Joshua B. Rager, Peter H. Schwartz, Kimberly A. Quaid, Margaret M. Gaffney, Jon Duke and William M. Tierney

    Citation: Clinical and Translational Medicine 2015 4:36

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    The Erratum to this article has been published in Clinical and Translational Medicine 2016 5:4

  28. Content type: Review

    High-throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architectur...

    Authors: Sunghee Oh, Hong Ji, Drew Barzman, Ping-I Lin and John Hutton

    Citation: Clinical and Translational Medicine 2015 4:37

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  29. Content type: Review

    Lung cancer is the most common cancer type worldwide and the leading cause of cancer related deaths in the United States. The majority of newly diagnosed patients present with late stage metastatic lung cancer...

    Authors: Miranda B. Carper and Pier Paolo Claudio

    Citation: Clinical and Translational Medicine 2015 4:33

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  30. Content type: Short report

    The development of commercially available panels for human blood plasma screening via selected reaction monitoring (SRM) offers reliable, cost-efficient and highly-standardized discovery and validation of prot...

    Authors: Olga I. Kiseleva, Yulia A. Romashova, Natalia E. Moskaleva, Natalia A. Petushkova, Nadezhda B. Teryaeva, Artem Yu. Belyaev and Andrey V. Lisitsa

    Citation: Clinical and Translational Medicine 2015 4:32

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  31. Content type: Research

    To assess the effect of respiratory training (RT) on lung function, activity tolerance and acute exacerbation frequency with chronic obstructive pulmonary disease (COPD).

    Authors: Fang Xi, Zheng Wang, Yong Qi, Richard Brightwell, Peter Roberts, Angus Stewart, Moira Sim and Wei Wang

    Citation: Clinical and Translational Medicine 2015 4:31

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  32. Content type: Editorial

    Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease. This has led to an ...

    Authors: Mingyan He, Jinglin Xia, Mohamed Shehab and Xiangdong Wang

    Citation: Clinical and Translational Medicine 2015 4:28

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  33. Content type: Research

    In the postgenomic era, it has become evident that analysis of genetic and protein expression changes alone is not sufficient to understand most disease processes in e.g. cardiovascular and cancer disease. Bio...

    Authors: Johan Malm, Henrik Lindberg, David Erlinge, Roger Appelqvist, Maria Yakovleva, Charlotte Welinder, Erik Steinfelder, Thomas E Fehniger and György Marko-Varga

    Citation: Clinical and Translational Medicine 2015 4:27

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  34. Content type: Research

    Genomic heterogeneity in human cancers complicates gene-centric personalized medicine. Malignant tumors often share a core group of pathways that are perturbed by diverse genetic mutations. Therefore, one poss...

    Authors: Haiyun Wang, Xiaoqi Zheng, Teng Fei, Jinzeng Wang, Xujuan Li, Yin Liu and Fan Zhang

    Citation: Clinical and Translational Medicine 2015 4:25

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  35. Content type: Research article

    In the new pathologic classification of lung adenocarcinoma proposed by IASLC/ATS/ERS in 2011, lepidic type adenocarcinomas are constituted by three subtypes; adenocarcinoma in situ (AIS), minimally invasive a...

    Authors: Yasufumi Kato, Haruhiko Nakamura, Hiromasa Tojo, Masaharu Nomura, Toshitaka Nagao, Takeshi Kawamura, Tatsuhiko Kodama, Tatsuo Ohira, Norihiko Ikeda, Thomas Fehniger, György Marko-Varga, Toshihide Nishimura and Harubumi Kato

    Citation: Clinical and Translational Medicine 2015 4:24

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  36. Content type: Review

    Despite improvements in critical care, acute respiratory distress syndrome (ARDS) remains a devastating clinical problem with high rates of morbidity and mortality. A better understanding of the prognostic fac...

    Authors: Wei Chen and Lorraine B Ware

    Citation: Clinical and Translational Medicine 2015 4:23

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  37. Content type: Research article

    Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and infl...

    Authors: Li Ma, Ciara M. Shaver, Brandon S. Grove, Daphne B. Mitchell, Nancy E. Wickersham, Robert H. Carnahan, Tracy L. Cooper, Brittany E. Brake, Lorraine B. Ware and Julie A. Bastarache

    Citation: Clinical and Translational Medicine 2015 4:22

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