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  1. Review

    Biofluid lipidome: a source for potential diagnostic biomarkers

    Lipidomics is the identification and quantitation of changes in the lipidome of a cell, tissue, organ or biofluid in health and disease using high resolution mass spectrometry. Lipidome of a particular organis...

    Arkasubhra Ghosh and Krishnatej Nishtala

    Clinical and Translational Medicine 2017 6:22

    Published on: 20 June 2017

  2. Review

    Single-cell RNA-sequencing of the brain

    Single-cell RNA-sequencing (scRNA-seq) is revolutionizing our understanding of the genomic, transcriptomic and epigenomic landscapes of cells within organs. The mammalian brain is composed of a complex network...

    Raquel Cuevas-Diaz Duran, Haichao Wei and Jia Qian Wu

    Clinical and Translational Medicine 2017 6:20

    Published on: 8 June 2017

  3. Review

    Can glypican-3 be a disease-specific biomarker?

    Glypican-3 (GPC3) is a cell surface-bound proteoglycan which has been identified as a potential biomarker candidate in hepatocellular carcinoma, lung carcinoma, severe pneumonia, and acute respiratory distress...

    Chaolei Chen, Xiaomin Huang, Zhaojian Ying, Dengmin Wu, Yani Yu, Xiangdong Wang and Chengshui Chen

    Clinical and Translational Medicine 2017 6:18

    Published on: 16 May 2017

  4. Review

    ETS-targeted therapy: can it substitute for MEK inhibitors?

    The RAS/MAPK pathway has been intensively studied in cancer. Constitutive activation of ERK1 and ERK2 is frequently found in cancer cells from a variety of tissues. In clinical practice and clinical trials, sm...

    Osamu Tetsu and Frank McCormick

    Clinical and Translational Medicine 2017 6:16

    Published on: 2 May 2017

  5. Review

    Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis

    Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-...

    Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth

    Clinical and Translational Medicine 2017 6:15

    Published on: 12 April 2017

  6. Perspective

    Translational research in pediatric pulmonary disease, 2017

    As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr...

    Bruce K. Rubin

    Clinical and Translational Medicine 2017 6:12

    Published on: 1 March 2017

  7. Review

    Single cell sequencing: a distinct new field

    Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se...

    Jian Wang and Yuanlin Song

    Clinical and Translational Medicine 2017 6:10

    Published on: 20 February 2017

  8. Commentary

    Integrating phosphoproteomics into the clinical management of prostate cancer

    Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip...

    Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake

    Clinical and Translational Medicine 2017 6:9

    Published on: 14 February 2017

  9. Commentary

    Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?

    Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm...

    Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt

    Clinical and Translational Medicine 2017 6:6

    Published on: 18 January 2017

  10. Research

    The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes

    The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...

    Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton

    Clinical and Translational Medicine 2017 6:5

    Published on: 18 January 2017

  11. Perspective

    A systematic approach to cancer: evolution beyond selection

    Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

    William B. Miller Jr. and John S. Torday

    Clinical and Translational Medicine 2017 6:2

    Published on: 3 January 2017

  12. Research

    MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)

    There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

    Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

    Clinical and Translational Medicine 2017 6:1

    Published on: 2 January 2017

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