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Clinical and Translational Medicine
Fig. 6 | Clinical and Translational Medicine

Fig. 6

From: The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats

Fig. 6

The LDL-uptake test in HepG2 (a) and Huh7 (b) cell models. The horizontal axis represents four different groups. The vertical axis represents the relative fluorescence unit (RFU) of the intracellular LDL, which reflects the levels of the LDL-c uptake and functional LDLR at the cell surface. The left two columns were respectively taken as the blank (full white) and negative (full black) control groups. The right six columns represent the other two groups of the monovalent VHH-B11, and the bivalency B11-Fc respectively in three doses (0.375, 0.750 and 1.500 μM). LDL-c uptake percent was given on the right of the histogram (←). ‘(+)’ and ‘(−)’refers to the addition and absence of hPCSK9 or VHH derivative antibodies, respectively. P < 0.05 was considered as statistically significant, compared with the negative control group (*P < 0.05, **P < 0.01, ***P < 0.001)

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