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Fig. 4 | Clinical and Translational Medicine

Fig. 4

From: RANKL/RANK promotes the migration of gastric cancer cells by interacting with EGFR

Fig. 4

RANKL promoted the formation of a RANK-Cav-1-EGFR complex. a The SGC-7901 and BGC-823 cells were treated with RANKL for the indicated times. Whole cell lysates were immune-precipitated with anti-Cav-1 antibody. The interaction of CAV-1 with RANK and EGFR was significantly enhanced providing by Western blot. b While silencing Cav-1 gene by using Cav-1 siRNAs for 72 h, and then treated with RANKL for indicated time. The formation ability of Cav-1-RANK-EGFR complex decreased significantly. Input represents cell lysates that were not subjected to immune-precipitation and IgG as an IP-control

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