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Clinical and Translational Medicine
Figure 3 | Clinical and Translational Medicine

Figure 3

From: Psoriasis drug development and GWAS interpretation through in silico analysis of transcription factor binding sites

Figure 3

PRE motifs significantly enriched in sequences upstream of psoriasis-decreased DEGs. We identified 461 PWM models matching motifs significantly enriched in sequences upstream of PP-decreased DEGs (FDR < 0.10). (A) The 200 most significantly enriched motifs were clustered as described in Figure 2, leading to the identification of two motif sub-groups. The yellow-black heat map shows PWM k-mer scores (top margin). Red-black heatmaps show enrichment scores indicating how well PWMs match those associated with DNA-binding domain superfamily and class groups. (B) Number of motifs associated with DNA-binding domain superfamilies. P-values assess whether motifs belonging to a superfamily are overrepresented among the 461 PRE motifs (right margin; Fisher’s Exact Test; asterisks denote FDR < 0.05). (C) Number of motifs associated with DNA-binding domain classes (top 10). P-values assess whether motifs from a given class are overrepresented among the 461 PRE motifs (right margin; Fisher’s Exact Test; asterisks denote FDR < 0.05).

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