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Table 1 Major tumor types organized by virulence, clinical significance, and epigenetic markers

From: EMT and tumor metastasis

Cancer type Survival 5-years after cancer has metastasized [ 61 ] Survival 5-years after diagnosis [ 61 ] EMT Markers References
Pancreas 2.3% 6.7% Snail, Twist, Zeb1, Zeb2, E-cadherin, β-catenin Brachyury, HDAC1,2,3, miR-34, miR-200, [62-65]
Liver 2.8% 16.6% Snail, Twist, Zeb1, Zeb2, TGF-β, EZH2, HDAC1,2,3, miR-101, STAT3, SUZ12, [62,66,67]
Lung 4.0% 16.8% Snail, Zeb1, Zeb2, E-cadherin, vimentin, α-catenin, EZH2, BMI1, Brachyury, Claudin-1, Cytokeratins, G9a, HDAC1,2,3, LSD1, miR-34, miR-101, miR-205, Periostin, Slug, SUZ12, TTF-1, versican, N-cadherin [62,63,66,68-71]
Bladder 5.5% 77.4% Twist, Zeb1, Zeb2, N-cadherin, EZH2, Fibronectin, LSD1, miRs-1/133a/218, miR-19a, miRs-30a-3p/133a/199a, miR-34, miR-99a/100, miR-101, miR-125b, miR-129, miR-145/133a, miR-200, miR-205, miR-221, N- [62,66,72]
Renal 12.1% 72.4% TGF-β, BMP-7, Claudin-1, HDAC1,2,3, hepatocyte growth factor, Klf8, miR-23b, miR-29b, miR-34, miRs-141/200, miR-205, miR-438-3p, [62,66,72-74]
Colorectal 12.9% 64.7% Snail, Twist, vimentin, Zeb1, Zeb2, β-catenin, Brachyury, CD44, E-cadherin, EZH2, FGFR4, Fibronectin, HDAC1,2,3, LSD1, miR-34, p16INK4a, SIRT1, Slug, SUZ12, SUV39H1, [62,63,66,72]
Cervical 16.1% 67.9% Snail, Twist, E-cadherin, vimentin, β-catenin, EGFR, [63,66,75,76]
Skin melanoma 16.1% 91.3% TGF-β, MITF, N-cadherin, miR-205 [62,77,78]
Ovarian 27.4% 44.6% Snail, Twist, Zeb1, Zeb2, E-cadherin, CCR7, Claudin-1, Fibronectin, Klf8, miR-9, miR-34, miR-200, N-cadherin, Occludin, PTEN, Slug, STK11, [62,63,66,72,79-82]
Breast 25.0% 89.2% Snail, Zeb1, Zeb2, vimentin, β-catenin, E-cadherin, BMI1, Brachyury, Claudin, EZH2, HDAC1,2,3, Klf8, LSD1, miR-9 (2); miR-10b, miR-34, Slug, SUZ12, Twist, versican, [62,63,66,68,69,83,84]
Prostate 28.0% 98.9% Twist, Zeb1, N-cadherin, APC, Cyclin D2, collagen, decorin, E47, E-cadherin, ER, EZH2, Fibronectin, GSTP1, HDAC1,2,3, Let-7a, LSD1, miR-1, miR-7, miR-15a-16 cluster, miR20a, miR-21, miR-24, miR-32, miR-34a, miR-34c, miR-101, miR-106b, miR-107, miR125b, miR-143, miR-145, miR-146a, miR-148a, miR-205, miR-221, miR-222, miR-331-3P, miR-449a, miR-521, miR-1296, Notch-1, RAR-β2, RASSF1A, versican, [62,63,72,85-88]
Brain/nervous system 35.6% 33.4% miR-9, Klf8 [62]