Variables | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |
Liver fibrosis score | ||||||
 NFS | 2.42 | 1.565–3.743 | < 0.001 | 1.488 | 1.086–2.039 | 0.013 |
 FIB-4 | 1.387 | 1.018–1.890 | 0.038 | 1.368 | 1.004–1.864 | 0.047 |
 APRI | 1.156 | 0.872–1.532 | 0.313 |  |  |  |
CRS | ||||||
 ≤ 2 | Reference |  |  | Reference |  |  |
 > 2 | 1.995 | 1.502–2.651 | < 0.001 | 1.952 | 1.469–2.595 | < 0.001 |
 Male gender | 0.856 | 0.647–1.133 | 0.278 |  |  |  |
 Age > 70 | 1.41 | 0.904–2.198 | 0.13 |  |  |  |
T stage | ||||||
 T1 | Reference |  |  |  |  |  |
 T2 | 0.644 | 0.260–1.595 | 0.341 |  |  |  |
 T3 | 0.829 | 0.378–1.815 | 0.639 |  |  |  |
 T4 | 0.795 | 0.371–1.705 | 0.556 |  |  |  |
N stage | ||||||
 N0 | Reference |  |  |  |  |  |
 N positive | 0.888 | 0.737–1.069 | 0.209 |  |  |  |
Location | ||||||
 Right-sided colon | Reference |  |  |  |  |  |
 Left-sided colon | 1.387 | 0.917–2.097 | 0.121 |  |  |  |
 Rectum | 1.425 | 0.986–2.059 | 0.059 |  |  |  |
Lymph node examined | 0.983 | 0.963–1.004 | 0.108 |  |  |  |
Mucinous Adenocarcinoma | 1.762 | 0.958–3.241 | 0.069 |  |  |  |
Perineural invasion | 1.124 | 0.826–1.528 | 0.457 |  |  |  |
Vascular invasion | 1.068 | 0.783–1.457 | 0.678 |  |  |  |
CEA | 1.557 | 1.168–2.075 | 0.003 | 1.346 | 1.003–1.808 | 0.048 |
Diabetes mellitus | 1.074 | 0.676–1.706 | 0.763 |  |  |  |
Obesity (BMI > 25) | 1.269 | 0.909–1.770 | 0.162 |  |  |  |