Clinical and Translational Medicine

Table 3 Risk factors for any hepatic metastasis postoperatively

From: Prediction of hepatic metastasis and relapse in colorectal cancers based on concordance analyses with liver fibrosis scores

Variables	Univariate analysis			Multivariate analysis
Variables	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Liver fibrosis score
NFS	1.677	1.213–2.319	0.002	1.664	1.189–2.329	0.003
FIB4	1.439	1.109–1.867	0.006	1.453	1.106–1.909	0.007
APRI	1.816	1.028–3.209	0.04	2.34	1.311–4.176	0.004
Male gender	1.555	1.098–2.203	0.013	1.49	1.049–2.116	0.026
Age > 70	1.508	1.043–2.181	0.029	1.521	1.031–2.244	0.034
T stage
T1	Reference			Reference
T2	1.536	0.735–3.210	0.254	1.456	0.696–3.046	0.319
T3	2.416	1.086–5.379	0.031	1.789	0.788–4.064	0.165
T4	2.945	1.483–5.848	0.002	2.168	1.080–4.352	0.03
N stage
N0	Reference
N1	1.456	1.012–2.094	0.043	0.174	0.893–1.862	0.174
N2	1.022	0.592–1.765	0.938	0.981	0.581–1.744	0.981
Location
Right-sided colon	Reference			Reference
Left-sided colon	0.616	0.383–0.991	0.046	0.702	0.434–1.138	0.151
Rectum	0.546	0.378–0.788	0.001	0.749	0.496–1.130	0.168
Lymph node examined	1.017	0.993–1.041	0.157
Mucinous Adenocarcinoma	1.756	1.073–2.876	0.025	1.39	0.839–2.304	0.202
Perineural invasion	1.298	0.845–1.996	0.234
Vascular invasion	1.333	0.909–1.954	0.142
Adjuvant therapy	2.983	1.987–4.476	< 0.001	2.726	1.782–4.171	< 0.001
Diabetes mellitus	0.996	0.584–1.700	0.99
Obesity (BMI > 25)	1.292	0.913–1.831	0.149

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