Fig. 6
From: PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma
Dexamethasone alone and in combination with BEZ235 partially reversed HDAC2 activity in the H2O2-U937 cell model. The HDAC2 activity assay results showed that H2O2 markedly reduced HDAC2 activity. Dexamethasone alone or in combination with a PI3K inhibitor (BEZ235) partially reversed HDAC2 activity, especially in the combination treatment group (p < 0.05: statistically significant. Each experiment was repeated at least three times)