Fig. 5
From: Detection of bladder cancer using urinary cell-free DNA and cellular DNA
Averaged diagnostic parameters of the logistic models for the genetic diagnosis of bladder cancer. For urine supernatant, all parameters of the models are satisfactory when gene combinations having three, four, and five genes (TERT, FGFR3, TP53, PIK3CA, and KRAS) were used. In contrast, the models using urine sediments require the combination of seven (TERT, FGFR3, TP53, HRAS, PIK3CA, KRAS, and ERBB2) or more genes to attain satisfactory predictive potential. The X-axis represents the number of genes factored into the model. The Y-axis plots diagnostic potential, with 1.0 representing perfect disease discrimination