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Table 3 FUMA gene set enrichment analysis results of KEGG pathways for identified associations (Adjusted P value < 0.05)

From: A trans-ethnic two-stage polygenetic scoring analysis detects genetic correlation between osteoporosis and schizophrenia

NameP valueAdjusted P value
Hip area vs. SCZ
 KEGG_AXON_GUIDANCE1.686 × 10−43.136 × 10−2
Hip total BMD vs. SCZ
 KEGG_AXON_GUIDANCE8.719E × 10−51.622 × 10−2
Hip neck Area vs. SCZ
 KEGG_GAP_JUNCTION2.239 × 10−42.157 × 10−2
 KEGG_CALCIUM_SIGNALING_PATHWAY3.006 × 10−42.157 × 10−2
 KEGG_GNRH_SIGNALING_PATHWAY3.480 × 10−42.157 × 10−2
Hip neck BMD vs. SCZ
 KEGG_ASCORBATE_AND_ALDARATE_METABOLISM9.782 × 10−71.462 × 10−4
 KEGG_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS1.572 × 10−61.462 × 10−4
 KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM7.543 × 10−64.677 × 10−4
 KEGG_DRUG_METABOLISM_OTHER_ENZYMES1.818 × 10−57.310 × 10−4
 KEGG_STARCH_AND_SUCROSE_METABOLISM1.965 × 10−57.310 × 10−4
 KEGG_STEROID_HORMONE_BIOSYNTHESIS2.458 × 10−57.621 × 10−4
 KEGG_RETINOL_METABOLISM4.485 × 10−51.192 × 10−3
 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P4506.381 × 10−51.473 × 10−3
 KEGG_DRUG_METABOLISM_CYTOCHROME_P4507.127 × 10−51.473 × 10−3
Spine area vs. SCZ
 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION3.722 × 10−66.922 × 10−4
 KEGG_NON_SMALL_CELL_LUNG_CANCER1.615 × 10−51.501 × 10−3
 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC9.799 × 10−56.076 × 10−3
 KEGG_CALCIUM_SIGNALING_PATHWAY4.238 × 10−41.971 × 10−2
 KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION9.590 × 10−43.567 × 10−2
 KEGG_GLYCEROLIPID_METABOLISM1.440 × 10−34.107 × 10−2
 KEGG_ECM_RECEPTOR_INTERACTION1.545 × 10−34.107 × 10−2
 KEGG_DILATED_CARDIOMYOPATHY2.096 × 10−34.874 × 10−2
Ulna & radius area vs. SCZ
 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION1.492 × 10−42.775 × 10−2