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Table 1 Clinical and laboratory characteristics of 304 patients associated with overall survival (OS)

From: The prognostic value of integration of pretreatment serum amyloid A (SAA)–EBV DNA (S-D) grade in patients with nasopharyngeal carcinoma

Patient characteristics

No. of patients (%)

Median OS (IQR)

P-valuea

Gender

 Male

232 (76.3%)

44.2 (38.5–47.4)

0.967

 Female

72 (23.7%)

44.8 (40.7–46.8)

 

Age (years)

 ≤46

157 (51.6%)

45.0 (40.6–47.8)

0.202

 > 46

147 (48.4%)

43.4 (37.2–46.8)

 

Tumor stage

 T1–2

52 (17.1%)

46.2 (41.9–49.8)

0.043

 T3–4

252 (82.9%)

44.0 (38.3–46.9)

 

Node stage

 N0–1

168 (55.3%)

44.5 (40.8–47.0)

0.007

 N2–3

136 (44.7%)

43.9 (36.0–47.8)

 

TNM stageb

 I–II

33 (10.9%)

45.8 (41.3–48.0)

0.048

 III–IV

271 (89.1%)

44.2 (39.2–47.1)

 

Treatment

 Radiotherapy

43 (14.1%)

44.0 (40.7–48.1)

0.047

 Chemoradiotherapy

261 (85.9%)

44.4 (38.7–47.0)

 

CRP (mg/L)

 ≤ 2.03

131 (43.1%)

44.6 (41.9–47.4)

0.001

 > 2.03

173 (56.9%)

44.1 (36.0–47.0)

 

SAA (mg/L)

 ≤ 4.46

154 (50.7%)

44.7 (41.7–47.4)

0.001

 > 4.46

150 (49.3%)

43.3 (35.2–47.1)

 

PLR

 ≤ 141.52

167 (54.9%)

44.0 (40.1–47.0)

0.287

 > 141.52

137 (45.1%)

45.1 (37.2–47.5)

 

NLR

 ≤ 2.62

149 (49.0%)

44.2 (40.6–47.5)

0.006

 > 2.62

155 (51.0%)

44.5 (36.1–47.0)

 

LMR

 ≤ 1.87

29 (9.5%)

45.3 (42.1–50.3)

0.415

 > 1.87

275 (90.5%)

44.2 (39.2–47.0)

 

EBV DNA (copies/mL)

 ≤ 2340

161 (53.0%)

45.0 (40.9–47.6)

<0.001

 > 2340

143 (47.0%)

43.4 (36.0–46.4)

 
  1. aSurvival was analyzed using Kaplan–Meier method and compared with Log-Rank test;
  2. bTNM stage was classified according to the AJCC 7th TNM staging system;
  3. IQR interquartile range, TNM tumor node metastasis stage, CRP C-reactive protein, SAA serum amyloid A, PLR platelet/lymphocyte ratio, NLR neutrophil/lymphocyte ratio, LMR ymphocyte/monocyte ratio, EBV Epstein-Barr virus