Fig. 1

Composition of the tumor microenvironment (TME). The tumor microenvironment is composed of tumor cells, cancer-associated fibroblasts (CAFs), the extracellular matrix (ECM), adipocytes, tumor vasculature and tumor-infiltrating lymphocytes and myeloid cells, all of which cross-talk intensively through cell surface molecules and/or soluble mediators to promote tumor growth and protect from host immunity and/or therapeutics