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Table 3 Therapy of choice based on tumor let-7 levels in different types of cancer

From: Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

Rational therapy choice based on let-7 expression
Cancer Let-7 levels Additional Therapy of choice
Colorectal High KRAS mutation Anti-EGFR therapy [45]
Ovarian High   Platinum [53]
Low   Platinum with Paclitaxel [53]
Breast Low   Taxol [56]
No response to Epirubicin [57]
Prostate Low   Resistant to androgen therapy [58]