Table 3 Therapy of choice based on tumor let-7 levels in different types of cancer
From: Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
Rational therapy choice based on let-7 expression | |||
|---|---|---|---|
Cancer | Let-7 levels | Additional | Therapy of choice |
Colorectal | High | KRAS mutation | Anti-EGFR therapy [45] |
Ovarian | High | Â | Platinum [53] |
Low | Â | Platinum with Paclitaxel [53] | |
Breast | Low | Â | Taxol [56] No response to Epirubicin [57] |
Prostate | Low | Â | Resistant to androgen therapy [58] |