Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Hsu, Hsien-Yeh; Hwang, Pai-An

doi:10.1186/s40169-019-0234-9

Clinical and Translational Medicine

Table 1 The anti-cancer effect of fucoidan from brown seaweeds on its cancer target and inhibitory mechanism/reaction

From: Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Cancer type	Research method	Fucoidan source	Anti-cancer mechanism/reaction	References
Acute leukemia	In vitro	Fucus vesiculosus	Induction of apoptosis	[18]
Lymphoma	In vitro and in vivo	Fucus vesiculosus	Oral administration of fucoidan inhibited tumor growth	[19, 20]
Head and neck cancer	In vitro and in vivo	Fucus vesiculosus	Injection of fucoidan-based nanoparticles inhibited tumor growth	[21]
Nasopharyngeal carcinoma	In vitro and in vivo	Laminaria japonica	Injection of fucoidan inhibited tumor growth and induced apoptosis	[22]
Oral cancer	In vitro	Fucus vesiculosus	Caspase-dependent apoptosis	[23]
Lung cancer	In vitro	Fucus vesiculosus	Inhibition of tumor migration and invasion	[24]
	In vitro	Turbinaria conoides	Induction of apoptosis	[27]
	In vitro and in vivo	Fucus vesiculosus Laminaria japonica	Oral administration of fucoidan modulated the TGFR/Smad7/Smurf2-dependent axis, leading to TGFR protein degradation and inhibition of lung cancer cell progression	[26]
	Human	Laminaria japonica	Survival rates of the lung cancer patients using cisplatin and fucoidan (oral administration) were increased by approximately 50% compared with those of the patients using cisplatin alone	[25]
Breast cancer	In vitro and in vivo	Fucus vesiculosus Laminaria japonica	Injection of fucoidan decreased tumor cell metastasis by enhancing ubiquitin-dependent TGF-β receptor degradation	[28]
Breast cancer	In vitro	Fucus vesiculosus	Higher branching degree of fucoidan had greater cytotoxicity of tumor cell	[29]
Gastric cancer	In vitro	Fucus vesiculosus	Induction of apoptosis and autophagy	[31]
Hepatoblastoma	In vitro	Cladosiphon okamuranus tokida	Induction of apoptosis and inhibition of cell cycle	[32]
Hepatocellular carcinoma	In vitro	Fucus vesiculosus	Induction of apoptosis	[33]
Cholangiocarcinoma	In vitro	Cladosiphon okamuranus tokida	Induction of apoptosis and inhibition of cell cycle	[32]
Prostate cancer		Undaria pinnatifida	Injection of fucoidan decreased tumor volume and increased apoptosis	[34]
Colorectal carcinoma	In vitro	Saccharina cichorioides	Low molecular weight fucoidan exhibited more anti-proliferation than native fucoidan	[35]
Colorectal carcinoma	In vitro	Fucus vesiculosus	Induction of apoptosis and decreased angiogenesis	[36]
Renal cancer	In vitro	Cladosiphon okamuranus tokida	Induction of apoptosis and inhibition of cell cycle	[32]
Ovarian cancer	In vitro	Cladosiphon okamuranus tokida	Induction of apoptosis and inhibition of cell cycle	[32]
Cervical cancer	Human	Nemacystis decipiens	Clinical improvement in cancer patients through integrated medicine, mainly using low molecular weight fucoidan supplements	[37]
Bladder cancer	In vitro	Fucus vesiculosus	Induction of G1 arrest of the cell cycle through down-regulation of pRB phosphorylation	[38]
Gallbladder cancer	In vitro	Cladosiphon okamuranus tokida	Induction of apoptosis and inhibition of cell cycle	[32]

Back to article page