Fig. 2
From: Cell membrane protein functionalization of nanoparticles as a new tumor-targeting strategy
Biomimetic nanoparticles (NPs) inherited specific properties from the donor cell source, such as: 1. ability to escape mononuclear phagocyte system (MPS) resulting from the expression of the “do not eat me” cell signal, CD47, and its interaction with its receptor signal-regulatory protein alpha (SIRPα) on the macrophage surface; 2. adhesion to inflamed endothelium and activation of the Lymphocyte function-associated antigen 1/Intracellular adhesion molecule-1 (LFA-1/ICAM-1) pathway that alters tight junctions between endothelial cells, resulting in increased vessel permeability; 3. tumor targeting potential via expression of tumor associated (TA) and homotypic binding (HB) antigens (Ag) recognized by tumor cells. TAMs Tumor associated macrophages