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Table 1 Glioblastoma multiforme classification by The Cancer Genome Atlas and World Health Organization

From: Combination therapy to checkmate Glioblastoma: clinical challenges and advances

Sub-class Genetic markers Median survival (months) References
Classical CDKN2A, EGFR, NES, PTEN, Notch and SHH pathway 12.2 [18]
Mesenchymal NF1, PTEN, TP53, TNF, NF-kB pathway 11.8 [18]
Proneural PDGFRA, IDH1, PIK3A/PIK3R1, CDKN2A, PTEN, SOX, DCX, DLL3, ASL1, TCF4 11.3 [18]
Neural EGFR, NEFL, GABRA1, SYT1, SLC12A5 13.1 [18]
Glioblastoma, IDH1 wild type TERT, TP53, EGFR, PTEN 9.9 [21]
Glioblastoma, IDH1 mutant TERT, TP53, ATRX 15 [21]