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Clinical and Translational Medicine
Fig. 2 | Clinical and Translational Medicine

Fig. 2

From: HIV-exposed uninfected infants: elevated cord blood Interleukin 8 (IL-8) is significantly associated with maternal HIV infection and systemic IL-8 in a Kenyan cohort

Fig. 2

HIV infection associated with changes in delivery and birth cytokine patterns. Cytokines were detected in samples from all maternal delivery plasma and infant cord blood plasma using multiplexed Luminex Elisa bead-based technology and grouped by broad category. Assays at or below the lower limit of detection were assigned the lowest limit of detection. Cytokines undetectable in the majority of HEU or HU samples were not included: IL-5, IL-21, IL-23 and CX3CL1. The ratio of infant cord blood to maternal delivery blood plasma cytokine levels was calculated. Each cytokine ratio is plotted for HU infant-HIV negative mother (open circles) and HEU infant-HIV-infected mother (closed circles) and the fold change from the HU group median is indicated. Independent group medians were compared using Mann–Whitney U test with correction for multiple comparisons p < 0.005. Significant mediators are bolded

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