Fig. 2
From: Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
The interplay between microRNAs and TGF-β signaling in regulating chemoresistance of cancer cells. There exists reciprocal modulation between TGF-β and diverse microRNAs. On one hand, TGF-β can affect the transcription of some microRNAs via specific effectors; On the other hand, TGF-β ligand or its receptor TGFBR are the targets of the corresponding microRNAs. These processes control the expression of EMT-related genes, leading to the morphology alteration accompanied with drug resistance in breast cancer