Fig. 7
EVARDSAlk5Runx1p66 decrease lung histological severity and restore lung endothelial permeability in LPS-treated mice. Representative H&E of lung sections illustrates the extent of perivascular cuffs (arrows) and thickening of the interstitium in mice treated with LPS only (b, c, d), EVARDSAlk5Runx1p66 (e), EVARDSAlk5Runx1p52 isolated from the blood of a long-term ARDS survivor, week 1 in ICU, when the EVARDS do not show Runx1p66 immunoreactivity (f) and EVARDSAlk5Runx1p52 of a non-surviving ARDS (g). a Comparison the H&E staining of a control, untreated mouse lung section. h Morphometric analyses of perivascular cuff area using the NIH ImageJ software; only small and medium-sized (20 ≥ diameter ≤ 100 μm) blood vessels were included. All data labels are included for each bar. Bar: 50 μm (a–g). n = 3 different EVARDS preparations in three independent experiments; *p < 0.01; **p < 0.05