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Clinical and Translational Medicine
Fig. 2 | Clinical and Translational Medicine

Fig. 2

From: Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Fig. 2

Group 1 pathophysiologic changes during the progression of ISIALI. Data from saline vehicle nebulized controls (n = 5, including one animal that died prematurely; before 48 h in the control vehicle group) or animals nebulized with tPA (n = 4) or scuPA (n = 3) in Group I at the 4 mg/unit dose are illustrated in a–f and plotted as line graphs with means and standard errors of the means. Nebulized plasminogen activators at the indicated doses were delivered according to the schedule illustrated in Fig. 1. a PaO2: arterial oxygen tension (mmHg): no significant difference between treatment groups over time. b PaO2/FiO2 ratios: statistically significant increase of scuPA (p = 0.02) and tPA (p < 0.001), compared to control. c, d Peak and plateau airway pressures (cmH2O): statistically significant decrement in tPA and scuPA treated groups compared to control (p < 0.001); scuPA treated was less than tPA (p = 0.03), independent of time. e Static lung compliance (mL/cmH2O/kg): no statistically significant difference between treatment groups as well as with control; f lung resistance (L/cmH2O/min): was significantly reduced in the scuPA 4 mg group (p = 0.045) but not in the tPA group. All depicted trends were statistically significant over time (p < 0.001). Statistical significance of treatment groups against controls over time is shown by solid (scuPA) or dashed (tPA) brackets

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