Fig. 6
From: Potential important roles and signaling mechanisms of YPEL4 in pulmonary diseases
A schematic diagram illustrating the role of YPEL4 in several cellular responses. From the top, epidermal growth factor (EGF) binds to the EGF receptor (EGFR) in the cell membrane, starting the signal transduction cascade. Downstream, phosphate (P) signaling activates MAPK. MAPK then phosphorylates Elk-1, a transcription factor that regulates gene expression of ITGB6. Increased levels angiotensin-II and potassium regulate YPEL4 expression and involvement in other pathways. PDS, pulmonary disease stimuli, may lead to the overexpression or downregulation of YPEL4 through their membrane and/or intracellular target (TPDS), implying its involvement in pulmonary diseases. The co-localization of YPEL4 and centrosome suggest YPEL involvement in the cell division process. (Dashed arrows: indirect interactions, solid arrows: direct interactions)