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Clinical and Translational Medicine
Fig. 4 | Clinical and Translational Medicine

Fig. 4

From: Cancer; an induced disease of twentieth century! Induction of tolerance, increased entropy and ‘Dark Energy’: loss of biorhythms (Anabolism v. Catabolism)

Fig. 4

Schematic representation of complex dynamics of immunity in aging and carcinogenesis. It depicts that effective immunity or balance in Yin and Yang of acute inflammation has the ability to kill cancerous cells; that initial stages of immune dysfunction could be corrected/reversed or prevented. It depicts that unresolved inflammation and aging skew proper immune responses (immune dysfunction), associated with altered genomic stability, expression and co-expression of pro-, and anti-inflammatory factors (unresolved inflammation), alterations in mitochondrial and ribosomal functions and loss of acid–base balance in tissues that would increase risk of carcinogenesis. The complex scheme also depicts that development of cancer drugs that are based on identification of numerous mutated/defective genes or growth expression products, at late stages of cancer (within cancer molecular tsunami) are claimed as cancer ‘targeted’ therapy, ‘precision’ or ‘personalized’ medicine. Drug-induced life-threatening side effects that cause multiple organ failures (MOFs) and patients’ death are also depicted. See text

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