Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Clinical and Translational Medicine

Table 3 Exonic de novo variants in the affected twin in family 1 (I-2-1)

Chr	Position	Ref	Sample	Type	Cytoband	Gene	Translation impact	dbSNP ID	1000 genomes	CG public genomes
1	117142868	CA	TG	Sub	1p13.1	IGSF3	In-frame
4	85996		C	Ins	4p16.3	ZNF595	*Frame shift*
4	86004	A	G	SNV	4p16.3	ZNF595	*Missense*	112290390
4	86022	CAG	GAC	Sub	4p16.3	ZNF595	In-frame	386670355
4	86043	T	C	SNV	4p16.3	ZNF595	Synonymous	377364445
7	100549935	T	G	SNV	7q22.1	MUC3A	*Missense*	73714229
7	100549942	T	C	SNV	7q22.1	MUC3A	*Missense*	73714230
7	100552452	T	C	SNV	7q22.1	MUC3A	Synonymous	112050489
11	48367133	C	A	SNV	11p11.2	OR4C45	*Missense*	79453749
12	40875389	CCATCAGCTGGAGTGACAGTGACATCCGGA		Del	12q12	MUC19	In-frame
12	40880542	C	T	SNV	12q12	MUC19	Missense	370502411		14.81
12	40880545	C	G	SNV	12q12	MUC19	Missense	199768257		16.66
12	122359397		GAGGAGGAGGAGAAA	Ins	12q24.31	WDR66	In-frame	142042908		67.59
13	25671607	GA	AG	Sub	13q12.13	PABPC3	In-frame	386769143
13	46170723	GATACTCTTCCTCCTCCA		Del	13q14.13	ERICH6B	In-frame
17	74288565	TGA		Del	17q25.1	QRICH2	In-frame	35035566	46.96	20.37
22	29885594	A	T	SNV	22q12.2	NEFH	Synonymous	79235463
22	29885599	AGGAAG		Del	22q12.2	NEFH	In-frame	149571560

Gene variants in bold are not known to be polymorphic and considered novel and potential pathogenic impact is marked in bolditalic