Table 10 Top 20 canonical pathways identified by ingenuity pathway analysis (IPA) in the affected twin of each family
Canonical pathways—family 1 affected (1A) | Shared with | p value |
|---|---|---|
1. CREB signaling in neurons | 2A, 2U | 0.0000041687 |
2. Neuropathic pain signaling in dorsal horn neurons | 2A, 1U, 2U | 0.0000083176 |
3. Axonal guidance signaling | 2A, 1U | 0.0000630957 |
4. Cellular effects of sildenafil (Viagra) | 2A, 1U | 0.0001479108 |
5. Role of NFAT in cardiac hypertrophy | – | 0.0001513561 |
6. Dopamine-DARPP32 feedback in cAMP signaling | 2A | 0.0002290868 |
7. Synaptic long term depression | 2A, 1U, 2U | 0.0002398833 |
8. Wnt/Ca+ pathway | – | 0.0003630781 |
9. Synaptic long term potentiation | 2A, 2U | 0.0008511380 |
10. PPARα/RXRα activation | 2U | 0.0011748976 |
11. Gap junction signaling | – | 0.0013803843 |
12. Glutamate receptor signaling | 2A | 0.0014791084 |
13. 14-3-3-mediated signaling | – | 0.0020417379 |
14. Netrin signaling | 2A, 1U, 2U | 0.0022908677 |
15. Leptin signaling in obesity | – | 0.0024547089 |
16. Nitric oxide signaling in the cardiovascular system | 2A, 1U | 0.0024547089 |
17. Hepatic cholestasis | 2U | 0.0026915348 |
18. Uracil degradation II (reductive) | 2U | 0.0029512092 |
19. Thymine degradation | 2U | 0.0029512092 |
20. Melatonin signaling | 1U | 0.0033113112 |
Canonical pathways—family 2 affected (2A) | Shared with | p value |
|---|---|---|
1. Sperm motility | 1U | 0.0000053703 |
2. Glutamate receptor signaling | 1A | 0.0000389045 |
3. Neuropathic pain signaling in dorsal horn neurons | 1A, 2U, 1U | 0.0000575440 |
4. Cellular effects of sildenafil (Viagra) | 1A, 1U | 0.0002238721 |
5. Nitric oxide signaling in the cardiovascular system | 1A, 1U | 0.0002884032 |
6. Synaptic long term depression | 1A, 2U, 1U | 0.0003235937 |
7. CREB signaling in neurons | 1A, 2U | 0.0003630781 |
8. Synaptic long term potentiation | 1A, 2U | 0.0005888437 |
9. Phospholipase C signaling | – | 0.0008709636 |
10. Netrin signaling | 1A, 2U, 1U | 0.0010964782 |
11. G-Protein coupled receptor signaling | 2U | 0.0012589254 |
12. α-adrenergic signaling | – | 0.0016595869 |
13. Protein kinase A signaling | 2U, 1U | 0.0023442288 |
14. nNOS signaling in neurons | – | 0.0040738028 |
15. Huntington’s disease signaling | – | 0.0042657952 |
16. Dopamine-DARPP32 feedback in cAMP signaling | 1A | 0.0058884366 |
17. Cardiac ÃŽ2-adrenergic signaling | 2U | 0.0067608298 |
18. Calcium signaling | 2U | 0.0077624712 |
19. Breast cancer regulation by Stathmin 1 | – | 0.0087096359 |
20. Axonal guidance signaling | 1A, 1U | 0.0089125094 |