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Table 10 Top 20 canonical pathways identified by ingenuity pathway analysis (IPA) in the affected twin of each family

From: Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia

Canonical pathways—family 1 affected (1A) Shared with p value
1. CREB signaling in neurons 2A, 2U 0.0000041687
2. Neuropathic pain signaling in dorsal horn neurons 2A, 1U, 2U 0.0000083176
3. Axonal guidance signaling 2A, 1U 0.0000630957
4. Cellular effects of sildenafil (Viagra) 2A, 1U 0.0001479108
5. Role of NFAT in cardiac hypertrophy 0.0001513561
6. Dopamine-DARPP32 feedback in cAMP signaling 2A 0.0002290868
7. Synaptic long term depression 2A, 1U, 2U 0.0002398833
8. Wnt/Ca+ pathway 0.0003630781
9. Synaptic long term potentiation 2A, 2U 0.0008511380
10. PPARα/RXRα activation 2U 0.0011748976
11. Gap junction signaling 0.0013803843
12. Glutamate receptor signaling 2A 0.0014791084
13. 14-3-3-mediated signaling 0.0020417379
14. Netrin signaling 2A, 1U, 2U 0.0022908677
15. Leptin signaling in obesity 0.0024547089
16. Nitric oxide signaling in the cardiovascular system 2A, 1U 0.0024547089
17. Hepatic cholestasis 2U 0.0026915348
18. Uracil degradation II (reductive) 2U 0.0029512092
19. Thymine degradation 2U 0.0029512092
20. Melatonin signaling 1U 0.0033113112
Canonical pathways—family 2 affected (2A) Shared with p value
1. Sperm motility 1U 0.0000053703
2. Glutamate receptor signaling 1A 0.0000389045
3. Neuropathic pain signaling in dorsal horn neurons 1A, 2U, 1U 0.0000575440
4. Cellular effects of sildenafil (Viagra) 1A, 1U 0.0002238721
5. Nitric oxide signaling in the cardiovascular system 1A, 1U 0.0002884032
6. Synaptic long term depression 1A, 2U, 1U 0.0003235937
7. CREB signaling in neurons 1A, 2U 0.0003630781
8. Synaptic long term potentiation 1A, 2U 0.0005888437
9. Phospholipase C signaling 0.0008709636
10. Netrin signaling 1A, 2U, 1U 0.0010964782
11. G-Protein coupled receptor signaling 2U 0.0012589254
12. α-adrenergic signaling 0.0016595869
13. Protein kinase A signaling 2U, 1U 0.0023442288
14. nNOS signaling in neurons 0.0040738028
15. Huntington’s disease signaling 0.0042657952
16. Dopamine-DARPP32 feedback in cAMP signaling 1A 0.0058884366
17. Cardiac Î2-adrenergic signaling 2U 0.0067608298
18. Calcium signaling 2U 0.0077624712
19. Breast cancer regulation by Stathmin 1 0.0087096359
20. Axonal guidance signaling 1A, 1U 0.0089125094
  1. 1A Family 1—affected twin, 1U Family 1—unaffected twin, 2A Family 2—affected twin, 2U Family 2—unaffected twin