Skip to main content

Table 5 Relationship between CXCL9-11 polymorphisms (CXCL9 rs10336, CXCL10 rs3921, and CXCL11 rs4619915) and liver fibrosis in HCV-infected patients (recessive inheritance model)

From: CXCL9-11 polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross-sectional study

  Unadjusted Adjusted
Exp(B) (95% CI) pa Exp(B) (95% CI) pb
rs10336 AA
 LSM (kPa) 1.21 (1.03; 1.49) 0.022 1.19 (1.02; 1.41) 0.030
  F2 (≥7.1) 2.09 (1.21; 3.63) 0.009 1.83 (1.02; 3.32) 0.044
  F3 (≥9.5) 2.01 (1.15; 3.47) 0.014 1.85 (1.02; 3.37) 0.045
  F4 (≥12.5) 1.81 (0.97; 3.98) 0.062 1.83 (0.94; 3.54) 0.073
rs3921 CC
 LSM (kPa) 1.21 (1.03; 1.44) 0.019 1.21 (1.03; 1.42) 0.023
  F2 (≥7.1) 2.03 (1.16; 3.52) 0.012 1.76 (0.97; 3.20) 0.061
  F3 (≥9.5) 2.07 (1.18; 3.59) 0.010 1.89 (1.04; 3.47) 0.038
  F4 (≥12.5) 1.86 (0.99; 3.48) 0.053 1.89 (0.97; 3.66) 0.061
rs4619915 AA
 LSM (kPa) 1.22 (1.03; 1.44) 0.019 1.21 (1.03; 1.42 0.023
  F2 (≥7.1) 2.03 (1.16; 3.53) 0.012 1.76 (0.97; 3.20) 0.061
  F3 (≥9.5) 2.07 (1.19; 3.59) 0.010 1.89 (1.04; 3.47) 0.038
  F4 (≥12.5) 1.86 (0.99; 3.49) 0.053 1.89 (0.97; 3.66) 0.061
  1. Exp(B) geometric mean ratio (GMR) for continuous variable or odds ratio (OR) for categorical variables, 95% CI 95% of confidence interval, p value level of significance, LSM liver stiffness measure, kPa kilopascal, F  2 significant fibrosis, F  3 advance fibrosis, F4 cirrhosis, HCV-GT hepatitis C virus genotype, CXCL chemokine (C-X-C motif) ligand
  2. Statistical: a p values were calculated by univariate regression
  3. bp values were calculated by multivariate regression adjusted by the most important clinical and epidemiological characteristics (see “statistical analysis” section). Statistically significant differences are shown in italic