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Clinical and Translational Medicine

Table 5 Relationship between CXCL9-11 polymorphisms (CXCL9 rs10336, CXCL10 rs3921, and CXCL11 rs4619915) and liver fibrosis in HCV-infected patients (recessive inheritance model)

From: CXCL9-11 polymorphisms are associated with liver fibrosis in patients with chronic hepatitis C: a cross-sectional study

 

Unadjusted

Adjusted

Exp(B) (95% CI)

pa

Exp(B) (95% CI)

pb

rs10336 AA

 LSM (kPa)

1.21 (1.03; 1.49)

0.022

1.19 (1.02; 1.41)

0.030

  F2 (≥7.1)

2.09 (1.21; 3.63)

0.009

1.83 (1.02; 3.32)

0.044

  F3 (≥9.5)

2.01 (1.15; 3.47)

0.014

1.85 (1.02; 3.37)

0.045

  F4 (≥12.5)

1.81 (0.97; 3.98)

0.062

1.83 (0.94; 3.54)

0.073

rs3921 CC

 LSM (kPa)

1.21 (1.03; 1.44)

0.019

1.21 (1.03; 1.42)

0.023

  F2 (≥7.1)

2.03 (1.16; 3.52)

0.012

1.76 (0.97; 3.20)

0.061

  F3 (≥9.5)

2.07 (1.18; 3.59)

0.010

1.89 (1.04; 3.47)

0.038

  F4 (≥12.5)

1.86 (0.99; 3.48)

0.053

1.89 (0.97; 3.66)

0.061

rs4619915 AA

 LSM (kPa)

1.22 (1.03; 1.44)

0.019

1.21 (1.03; 1.42

0.023

  F2 (≥7.1)

2.03 (1.16; 3.53)

0.012

1.76 (0.97; 3.20)

0.061

  F3 (≥9.5)

2.07 (1.19; 3.59)

0.010

1.89 (1.04; 3.47)

0.038

  F4 (≥12.5)

1.86 (0.99; 3.49)

0.053

1.89 (0.97; 3.66)

0.061

  1. Exp(B) geometric mean ratio (GMR) for continuous variable or odds ratio (OR) for categorical variables, 95% CI 95% of confidence interval, p value level of significance, LSM liver stiffness measure, kPa kilopascal, F ≥ 2 significant fibrosis, F ≥ 3 advance fibrosis, F4 cirrhosis, HCV-GT hepatitis C virus genotype, CXCL chemokine (C-X-C motif) ligand
  2. Statistical: a p values were calculated by univariate regression
  3. bp values were calculated by multivariate regression adjusted by the most important clinical and epidemiological characteristics (see “statistical analysis” section). Statistically significant differences are shown in italic
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