Fig. 1
From: Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis
Applications of single-cell sequencing in cancer research. a Resolving intratumor heterogeneity; b investigating clonal evolution in primary tumors; c studying invasion in early stage cancers; d tracing metastatic dissemination; e genomic profiling of circulating tumor cells; f investigating mutation rates and mutator phenotypes; g understanding evolution of resistance to therapy; h defining cancer stem cells and cell hierarchies; and i studying cell plasticity and the epithelial-to-mesenchymal transition [86]