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Clinical and Translational Medicine
Fig. 2 | Clinical and Translational Medicine

Fig. 2

From: Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta-catenin pathway

Fig. 2

Synthetic diagram of opposing effects of PPAR gamma and canonical WNT/beta-catenin signaling in cancer. Green arrow activation; red arrow inhibition; A-CoA acetyl-CoA, GSK-3beta glycogen synthase kinase-3beta, IC lactate intracellular lactate, EC lactate extracellular lactate, GSK-3beta glycogen synthase kinase-3beta, LDH-A lactico-dehydrogenase-A, MCT-1 monocarboxylate lactate transporter-1, PI3 K-AKT phosphatidylinositol 3-kinase-protein kinase B, PDH pyruvate dehydrogenase, PDK pyruvate dehydrogenase kinase, TCF/LEF T-cell factor/lymphoid enhancer factor, PPAR gamma peroxisome proliferator-activated receptor gamma

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