Fig. 1
From: Safety concerns and hidden agenda behind HPV vaccines: another generation of drug-dependent society?
‘Cancer Molecular Tsunami’. Photo (Japanese Tsunami, 2011) resembles severely disrupted integrities of molecular, cellular and sub-cellular structures of immune and non-immune systems in site-specific cancers. Candidate drugs are based on endless identification of defective molecules, genetic mutations of over-, under-, or co-expression of growth and apoptotic factors, cell surface and receptor molecules, decoy receptors, cytokines/chemokines, enzymes/proteins or vascular and membrane components (e.g., p53, ALK, AKT, NFkB, PI3K, MAPKs, Myc, Hsp-90, VEGF, EGFR, IGF, FGF, IFN-γ, TNFdR, MMPs, CRP, S1P, CD44, CD73, CD146, CD166, CD90, CD105/CD1-5, PTEN, TGF-β, PDL-1, IL-12, COs, LOs, TLRs, mTOR, caspases, tryptase, chymase, oxidases, PGE2). Photo Source: The Internet. Reproduced from Ref [1]; all rights reserved