Fig. 1

Functional organization of AVEC: anti-HER-2 × HBsAg. Antibody x vaccine engineered construct (AVEC): anti-HER-2 x HBsAg consists of the targeting and effector domains. The targeting domains constitute the complementarity determining regions (CDRs) for human epidermal growth factor receptor 2 (HER-2). The effector domains constitute: hepatitis B surface antigen (HBsAg); constant fragment receptor binding domain (FcR-BD); complement system binding domain (CS-BD)