Fig. 3
From: Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?
Schematic representation of a working model hypothesis explaining the function of immune surveillance, or Yin (tumoricidal, growth-arrest) and Yang (tumorigenic, growth-promote) of inflammation at different stages of life and age-associated diseases. The role of oxidative-stress-induced mitochondrial damage and the induction of carcinogenesis and neurodegenerative or autoimmune diseases are suggested to lead to differential damages of immune-responsive and immune-privileged tissues (see text)