Skip to main content

Table 1 Seventy protein candidates characterizing LPIA listed in increasing order of the Rsc (LPIA vs. MIA) values; the negatively larger the Rsc value of a given protein, the greater its expression level in LPIA compared with MIA and AIS

From: A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types

  Spectral counts (SpCs) Relative % thougtout stages Fold change in log2 (RSC) p-value in G-test
No Accession Number/Code Gene ID Description Protein length (AA) LPIA MIA AIS Total [LPIA] [MIA] [AIS] LPIA vs MIA LPIA vs AIS LPIA vs pN LPIA vs MIA LPIA vs AIS LPIA vs pN
1 HIP000323690 Band 7 protein family protein Band7 protein family protein 2858 77 0 0 77 100.0 0.0 0.0 -5.816 -5.758 -4.482 2.33E-22 5.80E-22 1.67E-13
2 P01892 HLA-A HLA class I histocompatibility antigen, A-2 alpha chain 365 34 0 0 34 100.0 0.0 0.0 -4.663 -4.605 -3.329 3.75E-10 5.59E-10 2.94E-06
3 Q15233 NONO Non-POU domain-containing octamer-binding protein 471 32 0 6 38 84.2 0.0 15.8 -4.579 -1.984 -3.244 1.38E-09 9.10E-05 6.39E-06
4 P31948 STIP1 Stress-induced-phosphoprotein 1 543 27 0 5 32 84.4 0.0 15.6 -4.344 -1.963 -3.009 3.63E-08 3.43E-04 4.45E-05
5 P10253 GAA Lysosomal alpha-glucosidase 952 26 0 0 26 100.0 0.0 0.0 -4.292 -4.233 -2.957 6.99E-08 9.48E-08 6.57E-05
6 Q07065 CKAP4 Cytoskeleton-associated protein 4 602 24 0 5 29 82.8 0.0 17.2 -4.181 -1.801 -2.847 2.58E-07 1.43E-03 1.43E-04
7 P17858 PFKL 6-phosphofructokinase, liver type 780 22 0 2 24 91.7 0.0 8.3 -4.062 -2.625 -2.727 9.55E-07 9.43E-05 3.11E-04
8 Q07960 ARHGAP1 Rho GTPase-activating protein 1 439 20 0 0 20 100.0 0.0 0.0 -3.932 -3.874 -2.598 3.53E-06 4.47E-06 6.77E-04
9 P06865 HEXA Beta-hexosaminidase subunit alpha 529 19 0 0 19 100.0 0.0 0.0 -3.863 -3.804 -2.528 6.80E-06 8.49E-06 9.99E-04
10 P53007 SLC25A1 Tricarboxylate transport protein, mitochondrial 311 18 0 0 18 100.0 0.0 0.0 -3.790 -3.731 -2.455 1.31E-05 1.61E-05 1.47E-03
11 P36871 PGM1 Phosphoglucomutase-1 562 18 0 0 18 100.0 0.0 0.0 -3.790 -3.731 -2.455 1.31E-05 1.61E-05 1.47E-03
12 A0A0A6YYG9 ARPC4-TTLL3 ARPC4-TTLL3 fusion protein 625 18 0 0 18 100.0 0.0 0.0 -3.790 -3.731 -2.455 1.31E-05 1.61E-05 1.47E-03
13 Q96HE7 ERO1L ERO1-like protein alpha 468 16 0 0 16 100.0 0.0 0.0 -3.631 -3.573 -2.296 4.84E-05 5.84E-05 3.21E-03
14 Q02218 OGDH 2-oxoglutarate dehydrogenase, mitochondrial 1023 16 0 1 17 94.1 0.0 5.9 -3.631 -2.725 -2.296 4.84E-05 5.45E-04 3.21E-03
15 P58107 EPPK1 Epiplakin 5090 15 0 0 15 100.0 0.0 0.0 -3.545 -3.487 -2.210 9.32E-05 1.11E-04 4.75E-03
16 P49588 AARS Alanine--tRNA ligase, cytoplasmic 968 15 0 0 15 100.0 0.0 0.0 -3.545 -3.487 -2.210 9.32E-05 1.11E-04 4.75E-03
17 P16615 ATP2A2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 997 15 0 0 15 100.0 0.0 0.0 -3.545 -3.487 -2.210 9.32E-05 1.11E-04 4.75E-03
18 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 340 14 0 0 14 100.0 0.0 0.0 -3.453 -3.395 -2.119 1.80E-04 2.11E-04 7.01E-03
19 O43760 SYNGR2 Synaptogyrin-2 224 14 0 0 14 100.0 0.0 0.0 -3.453 -3.395 -2.119 1.80E-04 2.11E-04 7.01E-03
20 O60701 UGDH UDP-glucose 6-dehydrogenase 494 12 0 0 12 100.0 0.0 0.0 -3.250 -3.192 -1.916 6.66E-04 7.66E-04 1.53E-02
21 Q5T2N8 ATAD3C ATPase family AAA domain-containing protein 3C 411 11 0 0 11 100.0 0.0 0.0 -3.137 -3.079 -1.802 1.28E-03 1.46E-03 2.27E-02
22 P46782 RPS5 40S ribosomal protein S5 204 11 0 0 11 100.0 0.0 0.0 -3.137 -3.079 -1.802 1.28E-03 1.46E-03 2.27E-02
23 Q8NBJ7 SUMF2 Sulfatase-modifying factor 2 301 11 0 2 13 84.6 0.0 15.4 -3.137 -1.700 -1.802 1.28E-03 3.46E-02 2.27E-02
24 Q96AE4 FUBP1 Far upstream element-binding protein 1 644 10 0 0 10 100.0 0.0 0.0 -3.014 -2.956 -1.679 2.48E-03 2.78E-03 3.36E-02
25 P46783 RPS10 40S ribosomal protein S10 165 10 0 0 10 100.0 0.0 0.0 -3.014 -2.956 -1.679 2.48E-03 2.78E-03 3.36E-02
26 P17516 AKR1C4 Aldo-keto reductase family 1 member C4 323 10 0 0 10 100.0 0.0 0.0 -3.014 -2.956 -1.679 2.48E-03 2.78E-03 3.36E-02
27 P15531 NME1 Nucleoside diphosphate kinase A 152 10 0 0 10 100.0 0.0 0.0 -3.014 -2.956 -1.679 2.48E-03 2.78E-03 3.36E-02
28 P15428 HPGD 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 266 10 0 0 10 100.0 0.0 0.0 -3.014 -2.956 -1.679 2.48E-03 2.78E-03 3.36E-02
29 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 548 10 0 0 10 100.0 0.0 0.0 -3.014 -2.956 -1.679 2.48E-03 2.78E-03 3.36E-02
30 P68036 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 154 9 0 0 9 100.0 0.0 0.0 -2.880 -2.821 -1.545 4.78E-03 5.30E-03 4.97E-02
31 P54802 NAGLU Alpha-N-acetylglucosaminidase 743 9 0 0 9 100.0 0.0 0.0 -2.880 -2.821 -1.545 4.78E-03 5.30E-03 4.97E-02
32 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic 935 9 0 0 9 100.0 0.0 0.0 -2.880 -2.821 -1.545 4.78E-03 5.30E-03 4.97E-02
33 P02790 HPX Hemopexin 462 9 0 0 9 100.0 0.0 0.0 -2.880 -2.821 -1.545 4.78E-03 5.30E-03 4.97E-02
34 A8MWD9 SNRPF Small nuclear ribonucleoprotein G-like protein 76 9 0 0 9 100.0 0.0 0.0 -2.880 -2.821 -1.545 4.78E-03 5.30E-03 4.97E-02
35 Q9Y3U8 RPL36 60S ribosomal protein L36 105 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
36 Q14247 CTTN Src substrate cortactin 634 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
37 P62491 RAB11A Ras-related protein Rab-11A 216 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
38 P56192 MARS Methionine--tRNA ligase, cytoplasmic 900 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
39 P12830 CDH1 Cadherin-1 882 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
40 P05166 PCCB Propionyl-CoA carboxylase beta chain, mitochondrial 559 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
41 O75347 TBCA Tubulin-specific chaperone A 108 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
42 O43684 BUB3 Mitotic checkpoint protein BUB3 328 8 0 0 8 100.0 0.0 0.0 -2.732 -2.673 -1.397 9.22E-03 1.01E-02 7.37E-02
43 Q9UM22 EPDR1 Mammalian ependymin-related protein 1 224 7 0 0 7 100.0 0.0 0.0 -2.567 -2.508 -1.232 1.78E-02 1.93E-02 1.09E-01
44 Q14376 GALE UDP-glucose 4-epimerase 348 7 0 0 7 100.0 0.0 0.0 -2.567 -2.508 -1.232 1.78E-02 1.93E-02 1.09E-01
45 P48637 GSS Glutathione synthetase 474 7 0 0 7 100.0 0.0 0.0 -2.567 -2.508 -1.232 1.78E-02 1.93E-02 1.09E-01
46 P47897 QARS Glutamine--tRNA ligase 775 7 0 0 7 100.0 0.0 0.0 -2.567 -2.508 -1.232 1.78E-02 1.93E-02 1.09E-01
47 P15941 MUC1 Mucin-1 475 7 0 0 7 100.0 0.0 0.0 -2.567 -2.508 -1.232 1.78E-02 1.93E-02 1.09E-01
48 O60763 USO1 General vesicular transport factor p115 962 7 0 0 7 100.0 0.0 0.0 -2.567 -2.508 -1.232 1.78E-02 1.93E-02 1.09E-01
49 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 705 12 1 0 13 92.3 7.7 0.0 -2.402 -3.192 -1.916 4.91E-03 7.66E-04 1.53E-02
50 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 358 12 1 1 14 85.7 7.1 7.1 -2.402 -2.344 -1.916 4.91E-03 5.59E-03 1.53E-02
51 Q9Y3I0 C22orf28 tRNA-splicing ligase RtcB homolog 505 6 0 0 6 100.0 0.0 0.0 -2.380 -2.322 -1.045 3.45E-02 3.70E-02 1.63E-01
52 Q9NRV9 HEBP1 Heme-binding protein 1 189 6 0 0 6 100.0 0.0 0.0 -2.380 -2.322 -1.045 3.45E-02 3.70E-02 1.63E-01
53 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 284 6 0 0 6 100.0 0.0 0.0 -2.380 -2.322 -1.045 3.45E-02 3.70E-02 1.63E-01
54 P49419 ALDH7A1 Alpha-aminoadipic semialdehyde dehydrogenase 539 6 0 0 6 100.0 0.0 0.0 -2.380 -2.322 -1.045 3.45E-02 3.70E-02 1.63E-01
55 P29590 PML Protein PML 633 6 0 0 6 100.0 0.0 0.0 -2.380 -2.322 -1.045 3.45E-02 3.70E-02 1.63E-01
56 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 501 6 0 0 6 100.0 0.0 0.0 -2.380 -2.322 -1.045 3.45E-02 3.70E-02 1.63E-01
57 P00533 EGFR Epidermal growth factor receptor 705 6 0 0 6 100.0 0.0 0.0 -2.380 -2.322 -1.045 3.45E-02 3.70E-02 1.63E-01
58 Q02252 ALDH6A1 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial 535 29 4 9 42 69.0 9.5 21.4 -2.372 -1.348 -3.108 2.84E-05 4.68E-03 2.05E-05
59 Q99829 CPNE1 Copine-1 537 26 4 7 37 70.3 10.8 18.9 -2.221 -1.510 -2.957 1.38E-04 3.51E-03 6.57E-05
60 Q15363 TMED2 Transmembrane emp24 domain-containing protein 2 201 10 1 0 11 90.9 9.1 0.0 -2.166 -2.956 -1.679 1.57E-02 2.78E-03 3.36E-02
61 P35221 CTNNA1 Catenin alpha-1 906 28 5 10 43 65.1 11.6 23.3 -2.072 -1.165 -3.059 1.61E-04 1.31E-02 3.02E-05
62 O75340 PDCD6 Programmed cell death protein 6 191 30 6 3 39 76.9 15.4 7.7 -1.953 -2.665 -3.155 1.78E-04 5.33E-06 1.39E-05
63 O00764 PDXK Pyridoxal kinase 312 11 2 2 15 73.3 13.3 13.3 -1.759 -1.700 -1.802 3.11E-02 3.46E-02 2.27E-02
64 P13667 PDIA4 Protein disulfide-isomerase A4 645 70 18 26 114 61.4 15.8 22.8 -1.735 -1.174 -4.346 1.64E-07 7.79E-05 2.52E-12
65 Q9NTX5 ECHDC1 Ethylmalonyl-CoA decarboxylase 307 28 7 1 36 77.8 19.4 2.8 -1.671 -3.487 -3.059 1.17E-03 4.05E-07 3.02E-05
66 Q7Z4W1 DCXR L-xylulose reductase 244 23 7 0 30 76.7 23.3 0.0 -1.400 -4.065 -2.788 9.91E-03 6.51E-07 2.11E-04
67 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 226 14 4 3 21 66.7 19.0 14.3 -1.383 -1.629 -2.119 4.58E-02 2.20E-02 7.01E-03
68 P49748 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 655 30 10 12 52 57.7 19.2 23.1 -1.319 -1.024 -3.155 4.98E-03 2.05E-02 1.39E-05
69 P42224 STAT1 Signal transducer and activator of transcription 1- alpha/beta 750 16 5 0 21 76.2 23.8 0.0 -1.309 -3.573 -2.296 4.13E-02 5.84E-05 3.21E-03
70 O95994 AGR2 Anterior gradient protein 2 homolog 175 58 23 14 95 61.1 24.2 14.7 -1.135 -1.746 -4.079 5.21E-04 1.57E-06 2.65E-10