Table 1 Seventy protein candidates characterizing LPIA listed in increasing order of the Rsc (LPIA vs. MIA) values; the negatively larger the Rsc value of a given protein, the greater its expression level in LPIA compared with MIA and AIS
From: A proteomic profiling of laser-microdissected lung adenocarcinoma cells of early lepidic-types
Spectral counts (SpCs) | Relative % thougtout stages | Fold change in log2 (RSC) | p-value in G-test | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No | Accession Number/Code | Gene ID | Description | Protein length (AA) | LPIA | MIA | AIS | Total | [LPIA] | [MIA] | [AIS] | LPIA vs MIA | LPIA vs AIS | LPIA vs pN | LPIA vs MIA | LPIA vs AIS | LPIA vs pN |
1 | HIP000323690 | Band 7 protein family protein | Band7 protein family protein | 2858 | 77 | 0 | 0 | 77 | 100.0 | 0.0 | 0.0 | -5.816 | -5.758 | -4.482 | 2.33E-22 | 5.80E-22 | 1.67E-13 |
2 | P01892 | HLA-A | HLA class I histocompatibility antigen, A-2 alpha chain | 365 | 34 | 0 | 0 | 34 | 100.0 | 0.0 | 0.0 | -4.663 | -4.605 | -3.329 | 3.75E-10 | 5.59E-10 | 2.94E-06 |
3 | Q15233 | NONO | Non-POU domain-containing octamer-binding protein | 471 | 32 | 0 | 6 | 38 | 84.2 | 0.0 | 15.8 | -4.579 | -1.984 | -3.244 | 1.38E-09 | 9.10E-05 | 6.39E-06 |
4 | P31948 | STIP1 | Stress-induced-phosphoprotein 1 | 543 | 27 | 0 | 5 | 32 | 84.4 | 0.0 | 15.6 | -4.344 | -1.963 | -3.009 | 3.63E-08 | 3.43E-04 | 4.45E-05 |
5 | P10253 | GAA | Lysosomal alpha-glucosidase | 952 | 26 | 0 | 0 | 26 | 100.0 | 0.0 | 0.0 | -4.292 | -4.233 | -2.957 | 6.99E-08 | 9.48E-08 | 6.57E-05 |
6 | Q07065 | CKAP4 | Cytoskeleton-associated protein 4 | 602 | 24 | 0 | 5 | 29 | 82.8 | 0.0 | 17.2 | -4.181 | -1.801 | -2.847 | 2.58E-07 | 1.43E-03 | 1.43E-04 |
7 | P17858 | PFKL | 6-phosphofructokinase, liver type | 780 | 22 | 0 | 2 | 24 | 91.7 | 0.0 | 8.3 | -4.062 | -2.625 | -2.727 | 9.55E-07 | 9.43E-05 | 3.11E-04 |
8 | Q07960 | ARHGAP1 | Rho GTPase-activating protein 1 | 439 | 20 | 0 | 0 | 20 | 100.0 | 0.0 | 0.0 | -3.932 | -3.874 | -2.598 | 3.53E-06 | 4.47E-06 | 6.77E-04 |
9 | P06865 | HEXA | Beta-hexosaminidase subunit alpha | 529 | 19 | 0 | 0 | 19 | 100.0 | 0.0 | 0.0 | -3.863 | -3.804 | -2.528 | 6.80E-06 | 8.49E-06 | 9.99E-04 |
10 | P53007 | SLC25A1 | Tricarboxylate transport protein, mitochondrial | 311 | 18 | 0 | 0 | 18 | 100.0 | 0.0 | 0.0 | -3.790 | -3.731 | -2.455 | 1.31E-05 | 1.61E-05 | 1.47E-03 |
11 | P36871 | PGM1 | Phosphoglucomutase-1 | 562 | 18 | 0 | 0 | 18 | 100.0 | 0.0 | 0.0 | -3.790 | -3.731 | -2.455 | 1.31E-05 | 1.61E-05 | 1.47E-03 |
12 | A0A0A6YYG9 | ARPC4-TTLL3 | ARPC4-TTLL3 fusion protein | 625 | 18 | 0 | 0 | 18 | 100.0 | 0.0 | 0.0 | -3.790 | -3.731 | -2.455 | 1.31E-05 | 1.61E-05 | 1.47E-03 |
13 | Q96HE7 | ERO1L | ERO1-like protein alpha | 468 | 16 | 0 | 0 | 16 | 100.0 | 0.0 | 0.0 | -3.631 | -3.573 | -2.296 | 4.84E-05 | 5.84E-05 | 3.21E-03 |
14 | Q02218 | OGDH | 2-oxoglutarate dehydrogenase, mitochondrial | 1023 | 16 | 0 | 1 | 17 | 94.1 | 0.0 | 5.9 | -3.631 | -2.725 | -2.296 | 4.84E-05 | 5.45E-04 | 3.21E-03 |
15 | P58107 | EPPK1 | Epiplakin | 5090 | 15 | 0 | 0 | 15 | 100.0 | 0.0 | 0.0 | -3.545 | -3.487 | -2.210 | 9.32E-05 | 1.11E-04 | 4.75E-03 |
16 | P49588 | AARS | Alanine--tRNA ligase, cytoplasmic | 968 | 15 | 0 | 0 | 15 | 100.0 | 0.0 | 0.0 | -3.545 | -3.487 | -2.210 | 9.32E-05 | 1.11E-04 | 4.75E-03 |
17 | P16615 | ATP2A2 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 997 | 15 | 0 | 0 | 15 | 100.0 | 0.0 | 0.0 | -3.545 | -3.487 | -2.210 | 9.32E-05 | 1.11E-04 | 4.75E-03 |
18 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 340 | 14 | 0 | 0 | 14 | 100.0 | 0.0 | 0.0 | -3.453 | -3.395 | -2.119 | 1.80E-04 | 2.11E-04 | 7.01E-03 |
19 | O43760 | SYNGR2 | Synaptogyrin-2 | 224 | 14 | 0 | 0 | 14 | 100.0 | 0.0 | 0.0 | -3.453 | -3.395 | -2.119 | 1.80E-04 | 2.11E-04 | 7.01E-03 |
20 | O60701 | UGDH | UDP-glucose 6-dehydrogenase | 494 | 12 | 0 | 0 | 12 | 100.0 | 0.0 | 0.0 | -3.250 | -3.192 | -1.916 | 6.66E-04 | 7.66E-04 | 1.53E-02 |
21 | Q5T2N8 | ATAD3C | ATPase family AAA domain-containing protein 3C | 411 | 11 | 0 | 0 | 11 | 100.0 | 0.0 | 0.0 | -3.137 | -3.079 | -1.802 | 1.28E-03 | 1.46E-03 | 2.27E-02 |
22 | P46782 | RPS5 | 40S ribosomal protein S5 | 204 | 11 | 0 | 0 | 11 | 100.0 | 0.0 | 0.0 | -3.137 | -3.079 | -1.802 | 1.28E-03 | 1.46E-03 | 2.27E-02 |
23 | Q8NBJ7 | SUMF2 | Sulfatase-modifying factor 2 | 301 | 11 | 0 | 2 | 13 | 84.6 | 0.0 | 15.4 | -3.137 | -1.700 | -1.802 | 1.28E-03 | 3.46E-02 | 2.27E-02 |
24 | Q96AE4 | FUBP1 | Far upstream element-binding protein 1 | 644 | 10 | 0 | 0 | 10 | 100.0 | 0.0 | 0.0 | -3.014 | -2.956 | -1.679 | 2.48E-03 | 2.78E-03 | 3.36E-02 |
25 | P46783 | RPS10 | 40S ribosomal protein S10 | 165 | 10 | 0 | 0 | 10 | 100.0 | 0.0 | 0.0 | -3.014 | -2.956 | -1.679 | 2.48E-03 | 2.78E-03 | 3.36E-02 |
26 | P17516 | AKR1C4 | Aldo-keto reductase family 1 member C4 | 323 | 10 | 0 | 0 | 10 | 100.0 | 0.0 | 0.0 | -3.014 | -2.956 | -1.679 | 2.48E-03 | 2.78E-03 | 3.36E-02 |
27 | P15531 | NME1 | Nucleoside diphosphate kinase A | 152 | 10 | 0 | 0 | 10 | 100.0 | 0.0 | 0.0 | -3.014 | -2.956 | -1.679 | 2.48E-03 | 2.78E-03 | 3.36E-02 |
28 | P15428 | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 266 | 10 | 0 | 0 | 10 | 100.0 | 0.0 | 0.0 | -3.014 | -2.956 | -1.679 | 2.48E-03 | 2.78E-03 | 3.36E-02 |
29 | O43776 | NARS | Asparagine--tRNA ligase, cytoplasmic | 548 | 10 | 0 | 0 | 10 | 100.0 | 0.0 | 0.0 | -3.014 | -2.956 | -1.679 | 2.48E-03 | 2.78E-03 | 3.36E-02 |
30 | P68036 | UBE2L3 | Ubiquitin-conjugating enzyme E2 L3 | 154 | 9 | 0 | 0 | 9 | 100.0 | 0.0 | 0.0 | -2.880 | -2.821 | -1.545 | 4.78E-03 | 5.30E-03 | 4.97E-02 |
31 | P54802 | NAGLU | Alpha-N-acetylglucosaminidase | 743 | 9 | 0 | 0 | 9 | 100.0 | 0.0 | 0.0 | -2.880 | -2.821 | -1.545 | 4.78E-03 | 5.30E-03 | 4.97E-02 |
32 | P11586 | MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic | 935 | 9 | 0 | 0 | 9 | 100.0 | 0.0 | 0.0 | -2.880 | -2.821 | -1.545 | 4.78E-03 | 5.30E-03 | 4.97E-02 |
33 | P02790 | HPX | Hemopexin | 462 | 9 | 0 | 0 | 9 | 100.0 | 0.0 | 0.0 | -2.880 | -2.821 | -1.545 | 4.78E-03 | 5.30E-03 | 4.97E-02 |
34 | A8MWD9 | SNRPF | Small nuclear ribonucleoprotein G-like protein | 76 | 9 | 0 | 0 | 9 | 100.0 | 0.0 | 0.0 | -2.880 | -2.821 | -1.545 | 4.78E-03 | 5.30E-03 | 4.97E-02 |
35 | Q9Y3U8 | RPL36 | 60S ribosomal protein L36 | 105 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
36 | Q14247 | CTTN | Src substrate cortactin | 634 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
37 | P62491 | RAB11A | Ras-related protein Rab-11A | 216 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
38 | P56192 | MARS | Methionine--tRNA ligase, cytoplasmic | 900 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
39 | P12830 | CDH1 | Cadherin-1 | 882 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
40 | P05166 | PCCB | Propionyl-CoA carboxylase beta chain, mitochondrial | 559 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
41 | O75347 | TBCA | Tubulin-specific chaperone A | 108 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
42 | O43684 | BUB3 | Mitotic checkpoint protein BUB3 | 328 | 8 | 0 | 0 | 8 | 100.0 | 0.0 | 0.0 | -2.732 | -2.673 | -1.397 | 9.22E-03 | 1.01E-02 | 7.37E-02 |
43 | Q9UM22 | EPDR1 | Mammalian ependymin-related protein 1 | 224 | 7 | 0 | 0 | 7 | 100.0 | 0.0 | 0.0 | -2.567 | -2.508 | -1.232 | 1.78E-02 | 1.93E-02 | 1.09E-01 |
44 | Q14376 | GALE | UDP-glucose 4-epimerase | 348 | 7 | 0 | 0 | 7 | 100.0 | 0.0 | 0.0 | -2.567 | -2.508 | -1.232 | 1.78E-02 | 1.93E-02 | 1.09E-01 |
45 | P48637 | GSS | Glutathione synthetase | 474 | 7 | 0 | 0 | 7 | 100.0 | 0.0 | 0.0 | -2.567 | -2.508 | -1.232 | 1.78E-02 | 1.93E-02 | 1.09E-01 |
46 | P47897 | QARS | Glutamine--tRNA ligase | 775 | 7 | 0 | 0 | 7 | 100.0 | 0.0 | 0.0 | -2.567 | -2.508 | -1.232 | 1.78E-02 | 1.93E-02 | 1.09E-01 |
47 | P15941 | MUC1 | Mucin-1 | 475 | 7 | 0 | 0 | 7 | 100.0 | 0.0 | 0.0 | -2.567 | -2.508 | -1.232 | 1.78E-02 | 1.93E-02 | 1.09E-01 |
48 | O60763 | USO1 | General vesicular transport factor p115 | 962 | 7 | 0 | 0 | 7 | 100.0 | 0.0 | 0.0 | -2.567 | -2.508 | -1.232 | 1.78E-02 | 1.93E-02 | 1.09E-01 |
49 | P46977 | STT3A | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A | 705 | 12 | 1 | 0 | 13 | 92.3 | 7.7 | 0.0 | -2.402 | -3.192 | -1.916 | 4.91E-03 | 7.66E-04 | 1.53E-02 |
50 | O43488 | AKR7A2 | Aflatoxin B1 aldehyde reductase member 2 | 358 | 12 | 1 | 1 | 14 | 85.7 | 7.1 | 7.1 | -2.402 | -2.344 | -1.916 | 4.91E-03 | 5.59E-03 | 1.53E-02 |
51 | Q9Y3I0 | C22orf28 | tRNA-splicing ligase RtcB homolog | 505 | 6 | 0 | 0 | 6 | 100.0 | 0.0 | 0.0 | -2.380 | -2.322 | -1.045 | 3.45E-02 | 3.70E-02 | 1.63E-01 |
52 | Q9NRV9 | HEBP1 | Heme-binding protein 1 | 189 | 6 | 0 | 0 | 6 | 100.0 | 0.0 | 0.0 | -2.380 | -2.322 | -1.045 | 3.45E-02 | 3.70E-02 | 1.63E-01 |
53 | Q9BPW8 | NIPSNAP1 | Protein NipSnap homolog 1 | 284 | 6 | 0 | 0 | 6 | 100.0 | 0.0 | 0.0 | -2.380 | -2.322 | -1.045 | 3.45E-02 | 3.70E-02 | 1.63E-01 |
54 | P49419 | ALDH7A1 | Alpha-aminoadipic semialdehyde dehydrogenase | 539 | 6 | 0 | 0 | 6 | 100.0 | 0.0 | 0.0 | -2.380 | -2.322 | -1.045 | 3.45E-02 | 3.70E-02 | 1.63E-01 |
55 | P29590 | PML | Protein PML | 633 | 6 | 0 | 0 | 6 | 100.0 | 0.0 | 0.0 | -2.380 | -2.322 | -1.045 | 3.45E-02 | 3.70E-02 | 1.63E-01 |
56 | P14868 | DARS | Aspartate--tRNA ligase, cytoplasmic | 501 | 6 | 0 | 0 | 6 | 100.0 | 0.0 | 0.0 | -2.380 | -2.322 | -1.045 | 3.45E-02 | 3.70E-02 | 1.63E-01 |
57 | P00533 | EGFR | Epidermal growth factor receptor | 705 | 6 | 0 | 0 | 6 | 100.0 | 0.0 | 0.0 | -2.380 | -2.322 | -1.045 | 3.45E-02 | 3.70E-02 | 1.63E-01 |
58 | Q02252 | ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial | 535 | 29 | 4 | 9 | 42 | 69.0 | 9.5 | 21.4 | -2.372 | -1.348 | -3.108 | 2.84E-05 | 4.68E-03 | 2.05E-05 |
59 | Q99829 | CPNE1 | Copine-1 | 537 | 26 | 4 | 7 | 37 | 70.3 | 10.8 | 18.9 | -2.221 | -1.510 | -2.957 | 1.38E-04 | 3.51E-03 | 6.57E-05 |
60 | Q15363 | TMED2 | Transmembrane emp24 domain-containing protein 2 | 201 | 10 | 1 | 0 | 11 | 90.9 | 9.1 | 0.0 | -2.166 | -2.956 | -1.679 | 1.57E-02 | 2.78E-03 | 3.36E-02 |
61 | P35221 | CTNNA1 | Catenin alpha-1 | 906 | 28 | 5 | 10 | 43 | 65.1 | 11.6 | 23.3 | -2.072 | -1.165 | -3.059 | 1.61E-04 | 1.31E-02 | 3.02E-05 |
62 | O75340 | PDCD6 | Programmed cell death protein 6 | 191 | 30 | 6 | 3 | 39 | 76.9 | 15.4 | 7.7 | -1.953 | -2.665 | -3.155 | 1.78E-04 | 5.33E-06 | 1.39E-05 |
63 | O00764 | PDXK | Pyridoxal kinase | 312 | 11 | 2 | 2 | 15 | 73.3 | 13.3 | 13.3 | -1.759 | -1.700 | -1.802 | 3.11E-02 | 3.46E-02 | 2.27E-02 |
64 | P13667 | PDIA4 | Protein disulfide-isomerase A4 | 645 | 70 | 18 | 26 | 114 | 61.4 | 15.8 | 22.8 | -1.735 | -1.174 | -4.346 | 1.64E-07 | 7.79E-05 | 2.52E-12 |
65 | Q9NTX5 | ECHDC1 | Ethylmalonyl-CoA decarboxylase | 307 | 28 | 7 | 1 | 36 | 77.8 | 19.4 | 2.8 | -1.671 | -3.487 | -3.059 | 1.17E-03 | 4.05E-07 | 3.02E-05 |
66 | Q7Z4W1 | DCXR | L-xylulose reductase | 244 | 23 | 7 | 0 | 30 | 76.7 | 23.3 | 0.0 | -1.400 | -4.065 | -2.788 | 9.91E-03 | 6.51E-07 | 2.11E-04 |
67 | Q9Y2Q3 | GSTK1 | Glutathione S-transferase kappa 1 | 226 | 14 | 4 | 3 | 21 | 66.7 | 19.0 | 14.3 | -1.383 | -1.629 | -2.119 | 4.58E-02 | 2.20E-02 | 7.01E-03 |
68 | P49748 | ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 655 | 30 | 10 | 12 | 52 | 57.7 | 19.2 | 23.1 | -1.319 | -1.024 | -3.155 | 4.98E-03 | 2.05E-02 | 1.39E-05 |
69 | P42224 | STAT1 | Signal transducer and activator of transcription 1- alpha/beta | 750 | 16 | 5 | 0 | 21 | 76.2 | 23.8 | 0.0 | -1.309 | -3.573 | -2.296 | 4.13E-02 | 5.84E-05 | 3.21E-03 |
70 | O95994 | AGR2 | Anterior gradient protein 2 homolog | 175 | 58 | 23 | 14 | 95 | 61.1 | 24.2 | 14.7 | -1.135 | -1.746 | -4.079 | 5.21E-04 | 1.57E-06 | 2.65E-10 |