Figure 5

SAHA-PIP: potential tool for selective transcriptional activation. (A) Chemical structure of SAHA-pyrrole-imidazole polyamide (SAHA-PIP) conjugate capable of site-specific acetylation in the promoter region of p16 tumor suppressor gene[71]. (B) SAHA-PIP `δ` triggers the core pluripotency gene network in mouse embryonic fibroblasts through site-specific epigenetic activation. In human dermal fibroblasts[74], (C) SAHA-PIP K and (D) SAHA-PIP A activates gene regulatory network associated with and germ cell and pancreas function such as glucose metabolism, respectively[12, 75].