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Clinical and Translational Medicine
Figure 4 | Clinical and Translational Medicine

Figure 4

From: Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control

Figure 4

Small molecules and β cell induction. Liver epithelial stem-like white blood (WB) cells can be reprogrammed into insulin-producing cells (IPCs) by sequential protocol using small molecules[68]. In the first stage, WB cells are dedifferentiated with 5-aza-2’-deoxycytidine (5-AZA) and Trichostatin A (TSA). Then, retinoic acid (RA) and a mix of insulin, transferrin and selenite (ITS) are added to induce PDX1-positive pancreatic precursor cells. Nicotinamide promotes maturation of IPCs in the last stage.

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