Skip to main content
Clinical and Translational Medicine
Figure 3 | Clinical and Translational Medicine

Figure 3

From: Cellular reprogramming for pancreatic β-cell regeneration: clinical potential of small molecule control

Figure 3

Insulin producing cells (IPCs) from various cell sources. (A) Overexpression of the defined exogenous transcription factors (Pdx1; Pdx1/VP16 (fusion protein) + NeuroD; Pdx1/VP16 (fusion protein) + Ngn3) in liver cells generate IPCs[53, 54]. (B) IPCs could also be induced from pancreatic non-β cells such as acinar cells and α-cells by forced expression of Ngn3 + Pdx1 + Mafa and Pax4, respectively[58]. (C) Adipose tissue-derived stem cells could be differentiated into functional IPCs by transducing Pdx1[59].

Back to article page