The Hippo pathway in disease and therapy: cancer and beyond

Gomez, Marta; Gomez, Valenti; Hergovich, Alexander

doi:10.1186/2001-1326-3-22

Clinical and Translational Medicine

Table 2 Summary of non-cancer mammalian pathologies in which YAP/TAZ proteins are involved

From: The Hippo pathway in disease and therapy: cancer and beyond

Tissue	Protein	Model	Pathology	References
Liver	YAP	Mouse models of inducible active YAP1 in the liver	Increase in liver size	[64, 65]
Heart	YAP/TAZ	SCA-1-/- human cardiac progenitor cell line	Infarct	[66]
	YAP/TAZ	Cardiac-specific YAP or TAZ knockout mice. Mouse model of inducible active YAP1 in the heart	Loss of function results in impaired neonatal heart regeneration and lethal cardiomyopathy. Activated YAP enhances cardiac regeneration and improves function of ischemic hearts	[67]
	YAP	Mouse models of arrhythmogenic cardiomyopathy and human samples	Arrhythmogenic Cardiomyopathy	[47]
	YAP	Mouse models of cardiomyocyte-specific homozygous inactivation of YAP in the postnatal heart	Increased myocyte apoptosis and fibrosis, dilated cardiomyopathy, and premature death.	[68]
Muscle	YAP	Mouse models of inducible active YAP in the skeletal muscle cells	Loss of body weight, gait impairments and kyphosis. Skeletal muscle atrophy.	[69]
Brain	YAP/TAZ	Rat model of chronic constriction sciatic nerve injury	Neuropathic pain	[70]
Brain	YAP/TAZ	Mammalian cell lines	Alzheimer’s disease	[71]
Pancreas	YAP	MST1/2 mutant conditional mouse	Reduction of pancreatic mass, exocrine pancreas disorganization and pancreatitis-like autodigestion	[54, 55]
Pancreas	YAP	Mouse models of inducible active YAP1 in the pancreas	Pancreas increased in total size and acinar cells showed penetrant ductal metaplasia	[64]
Skin	YAP/TAZ	Mice model of wound healing	Wound healing	[72]
Skin	YAP	Mouse models of inducible active YAP1 in the skin	Thickening of the epidermis and increased number of proliferating cells	[64]
Eye	YAP/TAZ	Primary human trabecular meshwork cells	Glaucoma	[73]
Ovary	YAP/TAZ	Mouse model of ovarian fragmentation, ovarian explant and follicle cultures. Primary ovarian insufficiency patients	Primary ovarian insufficiency and polycystic ovarian syndrome	[74]

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