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Table 6 Maspin expression in colorectal cancer

From: Role of maspin in cancer

Authors Years N. patients Maspin expression Clinical features/prognosis/predictive factors
Cao et al. 2005 25 (colorectal cancer and IBD) 88%positive maspin  
51 (active chronic IBD) 92% positive maspin
30 (inactive chronic IBD) 43% positive maspin
9(normal mucosa) 11% positive maspin
Song et al. 2002 66 (colorectal cancer) 75.5% positive maspin Positive maspin in colorectal cancer = 44.7% mutant p53 expression, microvessel density = 181.1+/−54.2
24(adenoma) 24.5% negative maspin Negative maspin in colorectal cancer = microvessel density = 256.1 +/75.4
91.7% positive maspin  
Positive maspin in adenoma = 0% mutant p53 expression
Jiang-tao et al. 2009 50 (colorectal cancer) 62% positive maspin Positive maspin in colorectal cancer = no association with positive lymphnode, higher Duke’s stage or mutant p53 expression
20 (adenoma) 90% positive maspin
20 (normal mucosa) 95%positive maspin
Zheng et al. 2007 119 (colorectal cancer) 95% positive maspin Positive maspin in colorectal cancer = no liver metastasis = 89% positive maspin
22 (adenoma) 93%positive maspin
118 (normal mucosa) 69%positive maspin
Umekita et al. 2006 104 (colorectal cancer) 66%positive maspin (15% = T1-T2 and 78.5% = T3-T4) Positive maspin = 44.2% absent tumor budding, 32.7% Duke’s stage B
Fung et al. 2010 450 (colorectal cancer) 81%positive cytoplasm 80% positive nucleus Positive maspin = right colon and high-grade tumor
Gurzu et al. 2012 101 (colorecatal cancer) 60% positive maspin Positive maspin = Stage II-III
Markl et al. 2010 156 (colorectal cancer stage I-II) 48% positive nucleus Positive nuclear maspin = pT3 OS = 40 months
72% positive cytoplasm Positive cytoplasmic maspin = pT3 OS = 63 months
Dietmaier et al. 2006 172 (colorectal cancer) 44.4% negative nucleus Negative nuclear maspin = OS: 79.2%, OS after 5FU: 32.5%
55.6% positive nucleus Positive nuclear maspin = OS:66.6%, OS after 5FU: 71.7%
24.1% negative cytoplasm
    75.9% positive cytoplasm