Table 6 Maspin expression in colorectal cancer
From: Role of maspin in cancer
Authors | Years | N. patients | Maspin expression | Clinical features/prognosis/predictive factors |
|---|---|---|---|---|
Cao et al. | 2005 | 25 (colorectal cancer and IBD) | 88%positive maspin | |
51 (active chronic IBD) | 92% positive maspin | |||
30 (inactive chronic IBD) | 43% positive maspin | |||
9(normal mucosa) | 11% positive maspin | |||
Song et al. | 2002 | 66 (colorectal cancer) | 75.5% positive maspin | Positive maspin in colorectal cancer = 44.7% mutant p53 expression, microvessel density = 181.1+/−54.2 |
24(adenoma) | 24.5% negative maspin | Negative maspin in colorectal cancer = microvessel density = 256.1 +/75.4 | ||
91.7% positive maspin | ||||
Positive maspin in adenoma = 0% mutant p53 expression | ||||
Jiang-tao et al. | 2009 | 50 (colorectal cancer) | 62% positive maspin | Positive maspin in colorectal cancer = no association with positive lymphnode, higher Duke’s stage or mutant p53 expression |
20 (adenoma) | 90% positive maspin | |||
20 (normal mucosa) | 95%positive maspin | |||
Zheng et al. | 2007 | 119 (colorectal cancer) | 95% positive maspin | Positive maspin in colorectal cancer = no liver metastasis = 89% positive maspin |
22 (adenoma) | 93%positive maspin | |||
118 (normal mucosa) | 69%positive maspin | |||
Umekita et al. | 2006 | 104 (colorectal cancer) | 66%positive maspin (15% = T1-T2 and 78.5% = T3-T4) | Positive maspin = 44.2% absent tumor budding, 32.7% Duke’s stage B |
Fung et al. | 2010 | 450 (colorectal cancer) | 81%positive cytoplasm 80% positive nucleus | Positive maspin = right colon and high-grade tumor |
Gurzu et al. | 2012 | 101 (colorecatal cancer) | 60% positive maspin | Positive maspin = Stage II-III |
Markl et al. | 2010 | 156 (colorectal cancer stage I-II) | 48% positive nucleus | Positive nuclear maspin = pT3 OS = 40 months |
72% positive cytoplasm | Positive cytoplasmic maspin = pT3 OS = 63 months | |||
Dietmaier et al. | 2006 | 172 (colorectal cancer) | 44.4% negative nucleus | Negative nuclear maspin = OS: 79.2%, OS after 5FU: 32.5% |
55.6% positive nucleus | Positive nuclear maspin = OS:66.6%, OS after 5FU: 71.7% | |||
24.1% negative cytoplasm | ||||
75.9% positive cytoplasm |