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Table 4 Maspin expression in lung cancer

From: Role of maspin in cancer

Authors Years N. patients Maspin expression Clinical features/prognosis/predictive factors
Bircan et al. 2010 28 (squamous cell lung cancer) 89.3% positive maspin  
   18 (lung adenocarcinoma) 77.8% positive maspin  
   17 (small cell lung cancer) 52.9% positive maspin  
Lonardo et al. 2005 46 (squamous cell lung cancer) 100% positive maspin Positive maspin = almost exclusively nuclear position
   77 (lung adenocarcinoma) 93,5% positive maspin Positive nuclear maspin in squamous cell lung cancer = low grade, low proliferative rate, absence of invasion, negative p53 vs nuclear-cytoplasmic position.
Frey et al. 2009 2009 80 (lung adenocarcinoma) 93.7% positive maspin  
    62.6% positive nucleus Positive nuclear maspin = 36.6% proliferative rate, Stage I OS: 87.7 ± 6.9 months, 42.5% moderate and poor differantation, 25,5% p53+, 4.2% high VEGF
    37.3% positive cytoplasm - nucleus Positive cytoplasmic maspin = 56.9%proliferative rate, Stage I OS: 58.7 ± 6.5 months, 71.4% moderate and poor differantation,53.5% p53+, 39.2% high VEGF
Woenckhaus et al. 2007 487 (tissue microarrays) 72.3% positive maspin  
    65.3% positive nucleus Positive nuclear maspin = 63.9% squamous cancer, 16.9%
    37.8% positive cytoplasm Positive cytoplasmic maspin = 78.2% squamous cancer, 6.8% adenocarcinoma adenocarcinoma
Hirai et al. 2005 112 (non-small cell lung cancer) 55.3%positive maspin Positive maspin = 77.8% positive cytoplasm Stage III and 36.2% positive cytoplasm Stage I
    44.7% negative maspin  
Berardi et al. 2010 439 (non-small cell lung cancer) 85.6% positive maspin Positive maspin = longer OS
    22.8% positive nucleus Positive nuclear maspin = independent prognostic factor
    44% positive cytoplasm Positive cytoplasmic maspin = especially smokers, lower OS than nuclear position
    14.4% negative maspin Negative maspin = Lower OS
Wu et al. 2012 160 (non-small cell lung cancer) 48.1% positive maspin Positive maspin = lower vasculogenic mimicry and microvessel density, longer OS, low Stage, low grade, low lymphnode metastasis
    51.9% negative maspin Negative maspin = higher vasculogenic mimicry and microvessel density, lower OS, high Stage, high grade, lymphnode metastasis
   20 (normal tissue) 100% positive maspin  
Nakagawa et al. 2006 210(non-small cell lung cancer) 73.7% positive maspin in squamous cancer Positive maspin = 70.1% 5-years OS
    26.3%negative maspin in squamous cancer Negative maspin = 41.5% 5-years OS
Katakura et al. 2006 55 (non-small cell lung cancer) Not found Positive maspin = 67.7% 5-years OS
     Negative maspin = 41.4% 5-years OS
Takanami et al. 2008 181 (non-small cell lung cancer) 40.8%positive maspin  
    65.7% positive maspin in squamous cancer Positive maspin in squamous cell lung cancer = 52.2% 5-years OS
    34.3%negative maspin in squamous cancer Negative maspin in squamous cell lung cancer = 24% OS 5 years OS
    22.8% positive maspin in adenocarcinoma  
    59.2% negative maspin