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Table 1 Characterization of renal progenitors from adult human kidneys

From: Regenerative medicine for the kidney: stem cell prospects & challenges

Origin & characteristics of human renal progenitor In vitro capacity In vivo renal injury model transplantation outcome Reference
CD133+, Pax2+ from renal cortex Self-renew, make tubular structures Engrafted into tubules of SCID mice with glycerol-induced tubulonecrosis [69]
CD133+, CD24+ in proximal & distal tubules Differentiate into renal epithelium & make tubular structures N.D. [70]
Aldhhigh, CD133+, CD24+ from proximal tubule N.D. N.D. [71]
CD133+, CD24+, CD106- in proximal & distal tubules High proliferative capacity; differentiate into podocyte & tubular lineages Engrafted into tubules of SCID mice with rhabdomyolysis induced AKI [72]
CD133+, CD24+, VIM+, observed in proximal tubule N.D. N.D. [73]
  1. Discrete antigen combinations have isolated renal progenitors that show remarkable potency in both in vitro culture and transplantation settings as indicated.