Table 1 Examples of application for genetics in the pathogenisis of ALI in 2011
From: Bioinformatics insights into acute lung injury/acute respiratory distress syndrome
Genes | Technologies | Relationship with ALI | Ref. |
|---|---|---|---|
NADPH oxidase | NOX2 subunit knockout mice | NOX-2(-/-) mice exhibited diminished TNF alpha-induced acute inflammatory responses in the lungs but not other tissues, as evidenced by decreased activation of the redox-sensitive transcription factor NF-kappa B, and decreased gene expression of IL-1 beta, IL-6, TNF alpha, E-selectin, and other cellular adhesion molecules. | [33] |
ANGPT | SNP array performed in ALI and non-ALI patients | An ANGPT2 region is associated with both ALI and variation in plasma angiopoietin-2 isoforms. | [31] |
Fas (CD95) | Genptyped 14 SNPs in FAS in healthy white volunteers and patients with ALI | Common genetic variants in FAS are associated with ALI susceptibility | [32] |
Surfactant protein B (SPB) | Genotyping was performed on seven linkage isequilibrium-tag SNP in the surfactant protein B gene | SPB are associated with more severe lung injury as indicated by the association of specific SNP genotypes and haplotypes with the need for mechanical ventilation in African American children with community-acquired pneumonia. | [34] |
Acvr1, Arhgap15, Cacnb4, Cacybp, Ccdc148,Fancl, Mycn, Mgat4a, Rfwd2, Tgfbr3, and Tnn | haplotype association mapping, microarray/qRT-PCR analyses, in silico SNP | 11 candidate genes are associated with acrolein-induced acute lung injury in 40 different inbred strains of mice | [35] |
IRAKs | tagging SNPs array | common SNPs in IRAK3 gene might be determinants for sepsis-induced ALI. association with ALI development among septic patients | [36] |
nmMLCK | nmMLCK knockout mice, nmMLCK silencing RNA | nmMLCK knockout mice were significantly protected from VILI, | [37] |